U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    H2AC18 H2A clustered histone 18 [ Homo sapiens (human) ]

    Gene ID: 8337, updated on 17-Jun-2024

    Summary

    Official Symbol
    H2AC18provided by HGNC
    Official Full Name
    H2A clustered histone 18provided by HGNC
    Primary source
    HGNC:HGNC:4736
    See related
    Ensembl:ENSG00000288825 MIM:142720; AllianceGenome:HGNC:4736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H2A; H2A.2; H2A/O; H2A/q; H2AFO; H2AC19; H2a-615; HIST2H2AA; HIST2H2AA3
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See H2AC18 in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149842218..149842750, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (148966358..148966890, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149813785..149814317, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H4 clustered histone 14 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149812048-149812621 Neighboring gene H3 clustered histone 14 Neighboring gene H2B clustered histone 19, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:149816892-149817655 Neighboring gene H4 clustered histone 15 Neighboring gene H2B clustered histone 20, pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat activated transcription facilitates removal of histones H2A and H2B at the LTR, and the FACT complex, at least consisting of SPT16 and SSRP1, may be responsible for their removal PubMed
    tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    part_of nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H2A type 2-A
    Names
    H2A histone family, member O
    H2A-clustered histone 19
    histone 2, H2aa3
    histone cluster 2 H2A family member a3
    histone cluster 2, H2aa3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003516.3NP_003507.1  histone H2A type 2-A

      See identical proteins and their annotated locations for NP_003507.1

      Status: REVIEWED

      Source sequence(s)
      AC239868
      Consensus CDS
      CCDS934.1
      UniProtKB/Swiss-Prot
      B2R5F0, P20670, Q6FI13
      UniProtKB/TrEMBL
      B2R5B3
      Related
      ENSP00000358155.2, ENST00000369159.3
      Conserved Domains (1) summary
      PTZ00017
      Location:1130
      PTZ00017; histone H2A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      149842218..149842750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      148966358..148966890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)