U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ACOX3 acyl-CoA oxidase 3, pristanoyl [ Homo sapiens (human) ]

    Gene ID: 8310, updated on 6-Sep-2022

    Summary

    Official Symbol
    ACOX3provided by HGNC
    Official Full Name
    acyl-CoA oxidase 3, pristanoylprovided by HGNC
    Primary source
    HGNC:HGNC:121
    See related
    Ensembl:ENSG00000087008 MIM:603402; AllianceGenome:HGNC:121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in esophagus (RPKM 3.5), skin (RPKM 3.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ACOX3 in Genome Data Viewer
    Location:
    4p16.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (8355305..8440723, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (8346177..8420469, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (8368009..8442450, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2517 Neighboring gene uncharacterized LOC124900658 Neighboring gene RNA, 5S ribosomal pseudogene 152 Neighboring gene tRNA methyltransferase 44 homolog Neighboring gene Sharpr-MPRA regulatory region 4448 Neighboring gene G protein-coupled receptor 78

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables pristanoyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    located_in peroxisomal matrix TAS
    Traceable Author Statement
    more info
     
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    peroxisomal acyl-coenzyme A oxidase 3
    Names
    BRCACox
    acyl-Coenzyme A oxidase 3, pristanoyl
    branched-chain acyl-CoA oxidase
    pristanoyl-CoA oxidase
    NP_001095137.1
    NP_001362712.1
    NP_001362713.1
    NP_001362714.1
    NP_001362715.1
    NP_001362716.1
    NP_001362717.1
    NP_001362718.1
    NP_001362719.1
    NP_003492.2
    XP_011511867.1
    XP_011511868.1
    XP_024310005.1
    XP_047272185.1
    XP_047272186.1
    XP_047272187.1
    XP_047272189.1
    XP_047272190.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101667.2NP_001095137.1  peroxisomal acyl-coenzyme A oxidase 3 isoform b

      See identical proteins and their annotated locations for NP_001095137.1

      Status: VALIDATED

      Source sequence(s)
      AC104825
      Consensus CDS
      CCDS47017.1
      UniProtKB/Swiss-Prot
      O15254
      Related
      ENSP00000413994.2, ENST00000413009.6
      Conserved Domains (1) summary
      cd01150
      Location:19609
      AXO; Peroxisomal acyl-CoA oxidase
    2. NM_001375783.1NP_001362712.1  peroxisomal acyl-coenzyme A oxidase 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC104825
      UniProtKB/Swiss-Prot
      Q96AJ8
      Related
      ENSP00000421625.1, ENST00000503233.5
      Conserved Domains (1) summary
      cd01150
      Location:19672
      AXO; Peroxisomal acyl-CoA oxidase
    3. NM_001375784.1NP_001362713.1  peroxisomal acyl-coenzyme A oxidase 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC104825
      Conserved Domains (1) summary
      cd01150
      Location:19648
      AXO; Peroxisomal acyl-CoA oxidase
    4. NM_001375785.1NP_001362714.1  peroxisomal acyl-coenzyme A oxidase 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC104825
      Conserved Domains (1) summary
      cd01150
      Location:19636
      AXO; Peroxisomal acyl-CoA oxidase
    5. NM_001375786.1NP_001362715.1  peroxisomal acyl-coenzyme A oxidase 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC104825
      Conserved Domains (1) summary
      cd01150
      Location:19636
      AXO; Peroxisomal acyl-CoA oxidase
    6. NM_001375787.1NP_001362716.1  peroxisomal acyl-coenzyme A oxidase 3 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC104825
      Conserved Domains (1) summary
      cd01150
      Location:19661
      AXO; Peroxisomal acyl-CoA oxidase
    7. NM_001375788.1NP_001362717.1  peroxisomal acyl-coenzyme A oxidase 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC104825
      Conserved Domains (1) summary
      cd01150
      Location:19609
      AXO; Peroxisomal acyl-CoA oxidase
    8. NM_001375789.1NP_001362718.1  peroxisomal acyl-coenzyme A oxidase 3 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC104825
      Conserved Domains (1) summary
      cd01150
      Location:4577
      AXO; Peroxisomal acyl-CoA oxidase
    9. NM_001375790.1NP_001362719.1  peroxisomal acyl-coenzyme A oxidase 3 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC104825
      Conserved Domains (1) summary
      cl09933
      Location:19551
      ACAD; Acyl-CoA dehydrogenase
    10. NM_003501.3NP_003492.2  peroxisomal acyl-coenzyme A oxidase 3 isoform a

      See identical proteins and their annotated locations for NP_003492.2

      Status: VALIDATED

      Source sequence(s)
      BC017053, CA306669, DA949869, Y11411
      Consensus CDS
      CCDS3401.1
      UniProtKB/Swiss-Prot
      O15254, Q96AJ8
      Related
      ENSP00000348775.4, ENST00000356406.10
      Conserved Domains (1) summary
      cd01150
      Location:19672
      AXO; Peroxisomal acyl-CoA oxidase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      8355305..8440723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416231.1XP_047272187.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X2

    2. XM_047416230.1XP_047272186.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X1

      UniProtKB/Swiss-Prot
      Q96AJ8
    3. XM_047416229.1XP_047272185.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X1

      UniProtKB/Swiss-Prot
      Q96AJ8
    4. XM_011513565.3XP_011511867.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X1

      See identical proteins and their annotated locations for XP_011511867.1

      UniProtKB/Swiss-Prot
      O15254, Q96AJ8
      Conserved Domains (1) summary
      cd01150
      Location:19672
      AXO; Peroxisomal acyl-CoA oxidase
    5. XM_011513566.2XP_011511868.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X2

      Conserved Domains (1) summary
      cd01150
      Location:19591
      AXO; Peroxisomal acyl-CoA oxidase
    6. XM_047416233.1XP_047272189.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X3

    7. XM_047416234.1XP_047272190.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X4

    8. XM_024454237.2XP_024310005.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X3

      Conserved Domains (1) summary
      cl09933
      Location:19476
      ACAD; Acyl-CoA dehydrogenase

    RNA

    1. XR_007057969.1 RNA Sequence

    2. XR_007057970.1 RNA Sequence

    3. XR_007057968.1 RNA Sequence

    4. XR_007057971.1 RNA Sequence

    5. XR_007057972.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      8346177..8420469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)