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    Sf3b1 splicing factor 3b, subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 81898, updated on 11-Sep-2021

    Summary

    Official Symbol
    Sf3b1provided by MGI
    Official Full Name
    splicing factor 3b, subunit 1provided by MGI
    Primary source
    MGI:MGI:1932339
    See related
    Ensembl:ENSMUSG00000025982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pr; SAP; Tar; TA-8; Prp10; Targ4; 155kDa; SAP155; SF3b15; SF3b155; AA409119; 2810001M05Rik
    Expression
    Ubiquitous expression in CNS E14 (RPKM 50.4), CNS E11.5 (RPKM 49.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sf3b1 in Genome Data Viewer
    Location:
    1 C1.2; 1 27.98 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (55024328..55066660, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (54985169..55027501, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (55042013..55084322, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19637 Neighboring gene RIKEN cDNA 4930444A19 gene Neighboring gene ankyrin repeat domain 44 Neighboring gene coenzyme Q10B Neighboring gene ribosomal protein S2 pseudogene Neighboring gene heat shock protein 1 (chaperonin) Neighboring gene heat shock protein 1 (chaperonin 10)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables splicing factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of U11/U12 snRNP ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U2 snRNP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U2 snRNP ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of small nuclear ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    splicing factor 3B subunit 1
    Names
    SAP 155
    pre-mRNA-splicing factor SF3b 155 kDa subunit
    spliceosome-associated protein 155
    splicing factor 3b, subunit 1, 155 kDa
    transforming growth factor alpha regulated gene 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031179.2NP_112456.2  splicing factor 3B subunit 1

      See identical proteins and their annotated locations for NP_112456.2

      Status: VALIDATED

      Source sequence(s)
      AK048521, AK077993, AK087700, AK140982, CF952155, CK331410, CN526934
      Consensus CDS
      CCDS35567.1
      UniProtKB/TrEMBL
      G5E866, Q3US00, Q8C2Y9, Q8C839
      Related
      ENSMUSP00000027127.8, ENSMUST00000027127.14
      Conserved Domains (4) summary
      smart01104
      Location:241382
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
      COG5181
      Location:4461304
      HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]
      sd00044
      Location:850874
      HEAT; HEAT repeat [structural motif]
      pfam08920
      Location:332442
      SF3b1; Splicing factor 3B subunit 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      55024328..55066660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154455.1XP_036010348.1  splicing factor 3B subunit 1 isoform X1

      Conserved Domains (4) summary
      smart01104
      Location:95236
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
      COG5181
      Location:3001158
      HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]
      sd00044
      Location:704728
      HEAT; HEAT repeat [structural motif]
      pfam08920
      Location:186296
      SF3b1; Splicing factor 3B subunit 1
    2. XM_036154457.1XP_036010350.1  splicing factor 3B subunit 1 isoform X1

      Conserved Domains (4) summary
      smart01104
      Location:95236
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
      COG5181
      Location:3001158
      HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]
      sd00044
      Location:704728
      HEAT; HEAT repeat [structural motif]
      pfam08920
      Location:186296
      SF3b1; Splicing factor 3B subunit 1

    RNA

    1. XR_003947333.1 RNA Sequence

    2. XR_003947332.1 RNA Sequence

      Related
      ENSMUST00000187500.7
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