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    QTRT1 queuine tRNA-ribosyltransferase catalytic subunit 1 [ Homo sapiens (human) ]

    Gene ID: 81890, updated on 17-Jun-2024

    Summary

    Official Symbol
    QTRT1provided by HGNC
    Official Full Name
    queuine tRNA-ribosyltransferase catalytic subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:23797
    See related
    Ensembl:ENSG00000213339 MIM:609615; AllianceGenome:HGNC:23797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TGT; TGUT; FP3235
    Summary
    This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 18.9), thyroid (RPKM 17.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See QTRT1 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10701439..10713365)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10827905..10839826)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10812115..10824041)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10763030-10763532 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10763533-10764034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10087 Neighboring gene ILF3 divergent transcript Neighboring gene interleukin enhancer binding factor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10801737-10802532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10802533-10803326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10806023-10806522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10811832-10812580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13985 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10826293-10826482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13990 Neighboring gene microRNA 638 Neighboring gene dynamin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10859277-10860091 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10861227-10861848 Neighboring gene uncharacterized LOC124904637

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in tRNA modification TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in tRNA-guanine transglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tRNA-guanine transglycosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tRNA-guanine transglycosylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of transferase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    queuine tRNA-ribosyltransferase catalytic subunit 1
    Names
    TGT, 43-KD subunit
    TGT, catalytic subunit
    guanine insertion enzyme
    queuine tRNA-ribosyltransferase 1
    tRNA-guanine transglycosylase
    NP_112486.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031209.3NP_112486.1  queuine tRNA-ribosyltransferase catalytic subunit 1

      See identical proteins and their annotated locations for NP_112486.1

      Status: REVIEWED

      Source sequence(s)
      AF302783, AF370379, CT003728
      Consensus CDS
      CCDS12248.1
      UniProtKB/Swiss-Prot
      B4DFM7, Q96BQ4, Q9BXQ9, Q9BXR0
      UniProtKB/TrEMBL
      B2RAR3
      Related
      ENSP00000250237.4, ENST00000250237.10
      Conserved Domains (1) summary
      cl19224
      Location:26376
      TGT; Queuine tRNA-ribosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10701439..10713365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      10827905..10839826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)