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    MED25 mediator complex subunit 25 [ Homo sapiens (human) ]

    Gene ID: 81857, updated on 8-Jul-2021

    Summary

    Official Symbol
    MED25provided by HGNC
    Official Full Name
    mediator complex subunit 25provided by HGNC
    Primary source
    HGNC:HGNC:28845
    See related
    Ensembl:ENSG00000104973 MIM:610197
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P78; ACID1; ARC92; BVSYS; PTOV2; CMT2B2; TCBAP0758
    Summary
    This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]
    Expression
    Broad expression in testis (RPKM 24.2), adrenal (RPKM 11.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See MED25 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49818289..49840384)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50321546..50343641)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 2 subunit alpha 1 Neighboring gene microRNA 6799 Neighboring gene uncharacterized LOC105372435 Neighboring gene fuzzy planar cell polarity protein Neighboring gene microRNA 6800 Neighboring gene PTOV1 antisense RNA 1 Neighboring gene PTOV1 extended AT-hook containing adaptor protein Neighboring gene PTOV1 antisense RNA 2 Neighboring gene microRNA 4749

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Basel-Vanagaite-Smirin-Yosef syndrome
    MedGen: C4225323 OMIM: 616449 GeneReviews: Not available
    Compare labs
    Charcot-Marie-Tooth disease type 2B2
    MedGen: C1854150 OMIM: 605589 GeneReviews: Not available
    Compare labs
    Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC70671, DKFZp434K0512

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinoic acid receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinoid X receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 25
    Names
    ARC/mediator transcriptional coactivator subunit
    activator interaction domain-containing protein 1
    activator-recruited cofactor 92 kDa component
    mediator of RNA polymerase II transcription, subunit 25 homolog
    prostate-derived protein 78 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017091.1 RefSeqGene

      Range
      5001..23702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_368

    mRNA and Protein(s)

    1. NM_001378355.1NP_001365284.1  mediator of RNA polymerase II transcription subunit 25 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC006942, AC018766, KC877749
      Related
      ENSP00000470692.3, ENST00000593767.3
      Conserved Domains (5) summary
      pfam11232
      Location:400545
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:228383
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:664715
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:12226
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
      pfam18658
      Location:730791
      zf-C2H2_12; Zinc-finger C2H2-type
    2. NM_030973.4NP_112235.2  mediator of RNA polymerase II transcription subunit 25 isoform 1

      See identical proteins and their annotated locations for NP_112235.2

      Status: REVIEWED

      Source sequence(s)
      BC065297, DC410997
      Consensus CDS
      CCDS33075.1
      UniProtKB/Swiss-Prot
      Q71SY5
      Related
      ENSP00000326767.5, ENST00000312865.10
      Conserved Domains (4) summary
      pfam11232
      Location:400545
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:228383
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:664747
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:13225
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      49818289..49840384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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