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    CAMK2G calcium/calmodulin dependent protein kinase II gamma [ Homo sapiens (human) ]

    Gene ID: 818, updated on 10-Dec-2024

    Summary

    Official Symbol
    CAMK2Gprovided by HGNC
    Official Full Name
    calcium/calmodulin dependent protein kinase II gammaprovided by HGNC
    Primary source
    HGNC:HGNC:1463
    See related
    Ensembl:ENSG00000148660 MIM:602123; AllianceGenome:HGNC:1463
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAMK; CAMKG; MRD59; CAMK-II
    Summary
    The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]
    Expression
    Ubiquitous expression in brain (RPKM 28.7), prostate (RPKM 10.9) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CAMK2G in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73812501..73874555, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74683897..74745947, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75572259..75634313, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NDST2-ZSWIM8-AS1 readthrough Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2490 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75574449-75574702 Neighboring gene N-deacetylase and N-sulfotransferase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579102-75579602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579603-75580103 Neighboring gene MPRA-validated peak1013 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75617818-75618318 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75618319-75618819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3580 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75646944-75648143 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:75648172-75649130 Neighboring gene uncharacterized LOC124902454 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75668366-75669565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2495 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:75672789-75673988 Neighboring gene chromosome 10 putative open reading frame 55 Neighboring gene plasminogen activator, urokinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of calcium/calmodulin-dependent protein kinase II gamma is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells PubMed
    tat HIV-1 Tat activates a CaMKII pathway at inhibitory synapses that leads to structural changes in GABARAP, resulting in increased membrane insertion of the gamma 2 subunit of GABAR PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16043, MGC26678

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of calcium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of skeletal muscle adaptation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of calcium- and calmodulin-dependent protein kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type II subunit gamma
    Names
    caMK-II subunit gamma
    calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
    NP_001191421.1
    NP_001213.2
    NP_001307827.1
    NP_001354443.1
    NP_001354445.1
    NP_001354446.1
    NP_001354447.1
    NP_001354448.1
    NP_001354449.1
    NP_001354450.1
    NP_001354451.1
    NP_001354452.1
    NP_001354453.1
    NP_001354454.1
    NP_001354455.1
    NP_001354456.1
    NP_001354457.1
    NP_001354458.1
    NP_001354459.1
    NP_001354460.1
    NP_001354461.1
    NP_001354462.1
    NP_001354463.1
    NP_001354464.1
    NP_001354465.1
    NP_001354466.1
    NP_001354467.1
    NP_001354468.1
    NP_001354469.1
    NP_001354470.1
    NP_001354471.1
    NP_001354472.1
    NP_001354473.1
    NP_001354474.1
    NP_001354475.1
    NP_001354476.1
    NP_001354477.1
    NP_751909.1
    NP_751910.1
    NP_751911.1
    NP_751913.1
    XP_005270255.1
    XP_005270262.1
    XP_006718059.1
    XP_006718061.1
    XP_016872219.1
    XP_024303986.1
    XP_047281753.1
    XP_047281754.1
    XP_047281755.1
    XP_047281756.1
    XP_047281757.1
    XP_047281758.1
    XP_047281759.1
    XP_047281760.1
    XP_047281761.1
    XP_054222819.1
    XP_054222820.1
    XP_054222821.1
    XP_054222822.1
    XP_054222823.1
    XP_054222824.1
    XP_054222825.1
    XP_054222826.1
    XP_054222827.1
    XP_054222828.1
    XP_054222829.1
    XP_054222830.1
    XP_054222831.1
    XP_054222832.1
    XP_054222833.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029408.2 RefSeqGene

      Range
      5037..67091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001204492.2NP_001191421.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 7

      See identical proteins and their annotated locations for NP_001191421.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has an alternate in-frame exon and lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 7) is shorter and lacks two internal segments compared to isoform 1.
      Source sequence(s)
      AC022400, AL596247, AL713896
      Consensus CDS
      CCDS73153.1
      UniProtKB/TrEMBL
      A8K6N9
      Related
      ENSP00000505103.1, ENST00000680035.1
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:407534
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    2. NM_001222.4NP_001213.2  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 4

      See identical proteins and their annotated locations for NP_001213.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (4), that is missing internal segments compared to isoform 1.
      Source sequence(s)
      AC022400, AL596247, AL713896, L07043
      Consensus CDS
      CCDS7336.1
      UniProtKB/TrEMBL
      A8K6N9
      Related
      ENSP00000277853.5, ENST00000351293.7
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:363490
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    3. NM_001320898.2NP_001307827.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022400, AK131199, AK225771, AW295338, BC034044, DR002605
      UniProtKB/TrEMBL
      B3KY86
      Conserved Domains (3) summary
      smart00220
      Location:14272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      cl09109
      Location:433488
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
    4. NM_001367514.1NP_001354443.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC022400, AK131199, AL596247
      UniProtKB/TrEMBL
      B3KY86
    5. NM_001367516.1NP_001354445.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      A8K6N9
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:386500
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    6. NM_001367517.1NP_001354446.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (50), as well as variant 3, encodes isoform 3.
      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      A8K6N9
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:386513
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    7. NM_001367518.1NP_001354447.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:412539
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    8. NM_001367519.1NP_001354448.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      B3KY86
    9. NM_001367520.1NP_001354449.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      B3KY86
    10. NM_001367521.1NP_001354450.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      B3KY86
    11. NM_001367522.1NP_001354451.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      B3KY86
    12. NM_001367523.1NP_001354452.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      B3KY86
    13. NM_001367524.1NP_001354453.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      B3KY86
    14. NM_001367525.1NP_001354454.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
      Conserved Domains (2) summary
      cd14086
      Location:12295
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:416543
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    15. NM_001367526.1NP_001354455.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      Related
      ENST00000700397.1
    16. NM_001367527.1NP_001354456.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      A0A8V8TQ60
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:422549
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    17. NM_001367528.1NP_001354457.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      B3KY86
    18. NM_001367529.1NP_001354458.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      B3KY86
    19. NM_001367530.1NP_001354459.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      A8K6N9
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:374501
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    20. NM_001367531.1NP_001354460.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      Consensus CDS
      CCDS91267.1
      UniProtKB/TrEMBL
      A8K6N9
      Related
      ENSP00000307082.7, ENST00000305762.11
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:397524
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    21. NM_001367532.1NP_001354461.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      A8K6N9
      Conserved Domains (2) summary
      cd14086
      Location:12295
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:378505
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    22. NM_001367533.1NP_001354462.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:410537
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    23. NM_001367534.1NP_001354463.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      Consensus CDS
      CCDS91269.1
      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
      UniProtKB/TrEMBL
      H0Y6G2
      Related
      ENSP00000410298.3, ENST00000423381.6
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:456583
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    24. NM_001367535.1NP_001354464.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      Conserved Domains (1) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    25. NM_001367536.1NP_001354465.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      A8K6N9
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:403530
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    26. NM_001367537.1NP_001354466.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247
      UniProtKB/TrEMBL
      Q8WU40
    27. NM_001367538.1NP_001354467.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247
    28. NM_001367539.1NP_001354468.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      Q8WU40
      Conserved Domains (2) summary
      pfam08332
      Location:342469
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:11221
      PKc_like; Protein Kinases, catalytic domain
    29. NM_001367540.1NP_001354469.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
    30. NM_001367541.1NP_001354470.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      B3KY86
    31. NM_001367542.1NP_001354471.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      A0A804CJ50
      Related
      ENSP00000378243.4, ENST00000394762.7
      Conserved Domains (2) summary
      pfam08332
      Location:194321
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:152
      PKc_like; Protein Kinases, catalytic domain
    32. NM_001367543.1NP_001354472.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      A8K6N9
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:418545
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    33. NM_001367544.1NP_001354473.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:445572
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    34. NM_001367545.1NP_001354474.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:401528
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    35. NM_001367546.1NP_001354475.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      A0A8V8TQ60
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:433560
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    36. NM_001367547.1NP_001354476.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 40

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:433560
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    37. NM_001367548.1NP_001354477.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    38. NM_172169.3NP_751909.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 2

      See identical proteins and their annotated locations for NP_751909.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple coding region differences, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AC022400, AL596247, BC034044
      Consensus CDS
      CCDS7337.1
      UniProtKB/TrEMBL
      A8K6N9
      Related
      ENSP00000315599.3, ENST00000322635.7
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:395522
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    39. NM_172170.5NP_751910.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3

      See identical proteins and their annotated locations for NP_751910.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), that is missing an internal segment compared to isoform 1. Variants 3 and 50 both encode the same isoform (3).
      Source sequence(s)
      AC022400, AL596247, AL713896
      UniProtKB/TrEMBL
      A8K6N9
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:386513
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    40. NM_172171.3NP_751911.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_751911.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC022400, AL596247, AL713896, U66063
      Consensus CDS
      CCDS7338.1
      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
      UniProtKB/TrEMBL
      A0A2Q3DQE3
      Related
      ENSP00000319060.3, ENST00000322680.7
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:424551
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    41. NM_172173.3NP_751913.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 6

      See identical proteins and their annotated locations for NP_751913.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (6), that is missing internal segments compared to isoform 1.
      Source sequence(s)
      AC022400, AL596247, AL713896, U50360
      UniProtKB/TrEMBL
      A8K6N9
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:372499
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    RNA

    1. NR_160040.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
    2. NR_160041.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
    3. NR_160042.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
    4. NR_160044.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
    5. NR_160045.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
    6. NR_160046.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
    7. NR_160047.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022400, AL596247, AL713896
    8. NR_160263.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022400, AK095576, AL596247

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      73812501..73874555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425803.1XP_047281759.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13

      UniProtKB/TrEMBL
      A8K6N9
    2. XM_047425802.1XP_047281758.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X12

      UniProtKB/TrEMBL
      A8K6N9
    3. XM_047425799.1XP_047281755.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5

      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    4. XM_047425800.1XP_047281756.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X7

      UniProtKB/TrEMBL
      A8K6N9
    5. XM_024448218.2XP_024303986.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPN2
      Conserved Domains (2) summary
      cd14086
      Location:12295
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:387514
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    6. XM_047425797.1XP_047281753.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1

      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    7. XM_017016730.2XP_016872219.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11

      UniProtKB/TrEMBL
      A8K6N9
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:383510
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    8. XM_006717996.2XP_006718059.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2

      See identical proteins and their annotated locations for XP_006718059.1

      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:435562
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    9. XM_005270205.2XP_005270262.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X10

      See identical proteins and their annotated locations for XP_005270262.1

      UniProtKB/TrEMBL
      A8K6N9, Q5SWX3
      Related
      ENSP00000361851.1, ENST00000372765.5
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:384511
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    10. XM_047425801.1XP_047281757.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8

      UniProtKB/TrEMBL
      A8K6N9
    11. XM_005270198.2XP_005270255.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X4

      See identical proteins and their annotated locations for XP_005270255.1

      UniProtKB/TrEMBL
      A0A8V8TQ60
      Related
      ENSP00000514974.1, ENST00000700396.1
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:431558
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    12. XM_006717998.2XP_006718061.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6

      See identical proteins and their annotated locations for XP_006718061.1

      UniProtKB/TrEMBL
      A8K6N9
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:404531
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    13. XM_047425798.1XP_047281754.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X3

      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    14. XM_047425805.1XP_047281761.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X15

      UniProtKB/TrEMBL
      Q8WU40
      Related
      ENSP00000393784.1, ENST00000433289.5
    15. XM_047425804.1XP_047281760.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X14

      UniProtKB/TrEMBL
      Q8WU40

    RNA

    1. XR_007061995.1 RNA Sequence

    2. XR_007061998.1 RNA Sequence

    3. XR_007062000.1 RNA Sequence

    4. XR_007061999.1 RNA Sequence

    5. XR_007061991.1 RNA Sequence

    6. XR_007061996.1 RNA Sequence

    7. XR_007061990.1 RNA Sequence

    8. XR_007061994.1 RNA Sequence

    9. XR_001747218.2 RNA Sequence

    10. XR_945822.2 RNA Sequence

    11. XR_945821.2 RNA Sequence

    12. XR_007061993.1 RNA Sequence

    13. XR_007061997.1 RNA Sequence

    14. XR_007061992.1 RNA Sequence

      Related
      ENST00000700399.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      74683897..74745947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366856.1XP_054222831.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13

      UniProtKB/TrEMBL
      A8K6N9
    2. XM_054366855.1XP_054222830.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X12

      UniProtKB/TrEMBL
      A8K6N9
    3. XM_054366848.1XP_054222823.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5

      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    4. XM_054366850.1XP_054222825.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X7

      UniProtKB/TrEMBL
      A8K6N9
    5. XM_054366852.1XP_054222827.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X9

      UniProtKB/TrEMBL
      A0A8V8TPN2
    6. XM_054366844.1XP_054222819.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1

      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    7. XM_054366854.1XP_054222829.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11

      UniProtKB/TrEMBL
      A8K6N9
    8. XM_054366845.1XP_054222820.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2

      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    9. XM_054366853.1XP_054222828.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X10

      UniProtKB/TrEMBL
      A8K6N9, Q5SWX3
    10. XM_054366851.1XP_054222826.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8

      UniProtKB/TrEMBL
      A8K6N9
    11. XM_054366847.1XP_054222822.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X4

      UniProtKB/TrEMBL
      A0A8V8TQ60
    12. XM_054366849.1XP_054222824.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6

      UniProtKB/TrEMBL
      A8K6N9
    13. XM_054366846.1XP_054222821.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X3

      UniProtKB/Swiss-Prot
      A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    14. XM_054366858.1XP_054222833.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X15

      UniProtKB/TrEMBL
      Q8WU40
    15. XM_054366857.1XP_054222832.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X14

      UniProtKB/TrEMBL
      Q8WU40

    RNA

    1. XR_008488282.1 RNA Sequence

    2. XR_008488285.1 RNA Sequence

    3. XR_008488287.1 RNA Sequence

    4. XR_008488286.1 RNA Sequence

    5. XR_008488278.1 RNA Sequence

    6. XR_008488283.1 RNA Sequence

    7. XR_008488276.1 RNA Sequence

    8. XR_008488281.1 RNA Sequence

    9. XR_008488275.1 RNA Sequence

    10. XR_008488277.1 RNA Sequence

    11. XR_008488274.1 RNA Sequence

    12. XR_008488280.1 RNA Sequence

    13. XR_008488284.1 RNA Sequence

    14. XR_008488279.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172172.1: Suppressed sequence

      Description
      NM_172172.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.