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    GP ALPHA 1 G protein alpha subunit 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817170, updated on 15-Oct-2023

    Summary

    Gene symbol
    GP ALPHA 1
    Gene description
    G protein alpha subunit 1
    Primary source
    Araport:AT2G26300
    Locus tag
    AT2G26300
    See related
    TAIR:AT2G26300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA G PROTEIN ALPHA SUBUNIT 1; ATGPA1; G PROTEIN ALPHA SUBUNIT; G protein alpha subunit 1; G PROTEIN ALPHA SUBUNIT 1; GPA1; T1D16.6; T1D16_6
    Summary
    Encodes an alpha subunit of a heterotrimeric GTP-binding protein. The active GTP-bound form of GPA1 binds to the GTG1 and GTG2 abscisic acid (ABA) receptors and appears to affect their GTPase and GTP-binding activity, and hence, ABA binding abilities. GPA1 is a positive regulator in ABA-mediated inhibition of stomatal opening. Plants with recessive mutant alleles have complex phenotypes including: reduced brassinolide response, reduced cell divisions, round leaves, short hypocotyls. It is likely to be involved in the signaling events that trigger unfolded protein response-associated cell death. GPA1 is also involved in sugar signaling.
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    Genomic context

    See GP ALPHA 1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    14
    Sequence:
    Chromosome: 2; NC_003071.7 (11196996..11201102)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene BRCT domain DNA repair protein Neighboring gene CTC-interacting domain 7 Neighboring gene root-specific kinase 1 Neighboring gene Chalcone-flavanone isomerase family protein Neighboring gene AGAMOUS-like 33

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    NM_128187.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within L-phenylalanine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within abscisic acid-activated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blue light signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gibberellic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within programmed cell death in response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of stomatal movement TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within response to glucose IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within response to low fluence blue light stimulus by blue low-fluence system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within seed germination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sphingosine-1-phosphate receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within thylakoid membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within tyrosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    G protein alpha subunit 1
    NP_180198.1
    • G protein alpha subunit 1 (GP ALPHA 1); FUNCTIONS IN: in 6 functions; INVOLVED IN: in 16 processes; LOCATED IN: plasma membrane, endoplasmic reticulum membrane, heterotrimeric G-protein complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Plant G-protein, alpha subunit (InterPro:IPR002976), Guanine nucleotide binding protein (G-protein), alpha subunit (InterPro:IPR001019), G protein alpha subunit, helical insertion (InterPro:IPR011025); BEST Arabidopsis thaliana protein match is: extra-large GTP-binding protein 3 (TAIR:AT1G31930.3); Has 3745 Blast hits to 3647 proteins in 408 species: Archae - 0; Bacteria - 0; Metazoa - 2360; Fungi - 766; Plants - 268; Viruses - 0; Other Eukaryotes - 351 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11196996..11201102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336055.1NP_001325056.1  G protein alpha subunit 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18064
      UniProtKB/TrEMBL
      A0A178VY32, A0A5S9X1K2
      Conserved Domains (1) summary
      cd00066
      Location:40377
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    2. NM_128187.3NP_180198.1  G protein alpha subunit 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180198.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18064
      UniProtKB/TrEMBL
      A0A178VY32, A0A5S9X1K2
      Conserved Domains (1) summary
      cd00066
      Location:40377
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)