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    Ankrd17 ankyrin repeat domain 17 [ Mus musculus (house mouse) ]

    Gene ID: 81702, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ankrd17provided by MGI
    Official Full Name
    ankyrin repeat domain 17provided by MGI
    Primary source
    MGI:MGI:1932101
    See related
    Ensembl:ENSMUSG00000055204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Foe; Gtar; Mask; AA407558; AA516750; AU040470; mKIAA0697; A930008M01; 4933425K22Rik; A130069E23Rik
    Summary
    This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies suggest that this protein is involved in liver development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta adult (RPKM 15.9), whole brain E14.5 (RPKM 11.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ankrd17 in Genome Data Viewer
    Location:
    5; 5 E1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (90227166..90366572, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (90656191..90795211, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35936 Neighboring gene cytochrome c oxidase assembly protein 18 Neighboring gene predicted gene 9958 Neighboring gene predicted gene, 35999

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    blood vessel maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    endoderm development TAS
    Traceable Author Statement
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MDA-5 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat domain-containing protein 17
    Names
    ankyrin repeat domain containing protein FOE
    gene trap ankyrin repeat protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030886.2NP_112148.2  ankyrin repeat domain-containing protein 17 isoform a

      See identical proteins and their annotated locations for NP_112148.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC140220, AC162171
      Consensus CDS
      CCDS57354.1
      UniProtKB/Swiss-Prot
      Q99NH0
      Related
      ENSMUSP00000014421.8, ENSMUST00000014421.14
      Conserved Domains (9) summary
      TIGR02926
      Location:801877
      AhaH; ATP synthase archaeal, H subunit
      smart00248
      Location:10781106
      ANK; ankyrin repeats
      COG0666
      Location:10421268
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00105
      Location:17231785
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:392516
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam03938
      Location:790889
      OmpH; Outer membrane protein (OmpH-like)
      pfam12796
      Location:301390
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:13491402
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:431460
      ANK; ANK repeat [structural motif]
    2. NM_198010.2NP_932127.2  ankyrin repeat domain-containing protein 17 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC140220, AC162171
      Consensus CDS
      CCDS57353.1
      UniProtKB/TrEMBL
      E9QKG6
      Related
      ENSMUSP00000080587.6, ENSMUST00000081914.12
      Conserved Domains (6) summary
      COG0666
      Location:7911017
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00105
      Location:14721534
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:392516
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:301390
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10981151
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:431460
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      90227166..90366572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535289.3XP_006535352.2  ankyrin repeat domain-containing protein 17 isoform X5

      Conserved Domains (6) summary
      COG0666
      Location:7901016
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00105
      Location:14711533
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:392516
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:301390
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10971150
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:431460
      ANK; ANK repeat [structural motif]
    2. XM_006535287.3XP_006535350.2  ankyrin repeat domain-containing protein 17 isoform X1

      UniProtKB/TrEMBL
      E9Q804
      Related
      ENSMUSP00000128960.3, ENSMUST00000168058.6
    3. XM_006535288.3XP_006535351.2  ankyrin repeat domain-containing protein 17 isoform X2

    4. XM_006535290.3XP_006535353.1  ankyrin repeat domain-containing protein 17 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JDZ9
      Related
      ENSMUSP00000142575.1, ENSMUST00000197021.1
      Conserved Domains (9) summary
      TIGR02926
      Location:692768
      AhaH; ATP synthase archaeal, H subunit
      smart00248
      Location:969997
      ANK; ankyrin repeats
      COG0666
      Location:9331159
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00105
      Location:16141676
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:283407
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam03938
      Location:681780
      OmpH; Outer membrane protein (OmpH-like)
      pfam12796
      Location:192281
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:12401293
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:322351
      ANK; ANK repeat [structural motif]
    5. XM_006535291.2XP_006535354.1  ankyrin repeat domain-containing protein 17 isoform X4

      Conserved Domains (9) summary
      TIGR02926
      Location:675751
      AhaH; ATP synthase archaeal, H subunit
      smart00248
      Location:952980
      ANK; ankyrin repeats
      COG0666
      Location:9161142
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00105
      Location:15971659
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00204
      Location:266390
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam03938
      Location:664763
      OmpH; Outer membrane protein (OmpH-like)
      pfam12796
      Location:175264
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:12231276
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:305334
      ANK; ANK repeat [structural motif]
    6. XM_011249595.2XP_011247897.2  ankyrin repeat domain-containing protein 17 isoform X6

    7. XM_017321182.1XP_017176671.1  ankyrin repeat domain-containing protein 17 isoform X7

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