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    AMN amnion associated transmembrane protein [ Homo sapiens (human) ]

    Gene ID: 81693, updated on 5-Mar-2024

    Summary

    Official Symbol
    AMNprovided by HGNC
    Official Full Name
    amnion associated transmembrane proteinprovided by HGNC
    Primary source
    HGNC:HGNC:14604
    See related
    Ensembl:ENSG00000166126 MIM:605799; AllianceGenome:HGNC:14604
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IGS2; PRO1028; amnionless
    Summary
    The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in kidney (RPKM 39.0), small intestine (RPKM 30.0) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AMN in Genome Data Viewer
    Location:
    14q32.32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102922663..102930842)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97158908..97167087)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103389000..103397179)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9085 Neighboring gene TNF receptor associated factor 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103276021-103276180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103294403-103294902 Neighboring gene NANOG hESC enhancer GRCh37_chr14:103307110-103307650 Neighboring gene RNA, U6 small nuclear 1316, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:103352003-103353202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103357046-103357546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103357547-103358047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103366521-103367022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103367023-103367522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103379429-103380018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103380019-103380608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103380952-103381452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6134 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103390587-103390785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6136 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:103411482-103412681 Neighboring gene CDC42 binding protein kinase beta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103452779-103453413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103453414-103454047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103464738-103465284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9093 Neighboring gene Sharpr-MPRA regulatory region 6354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103486267-103486822 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:103489632-103489899 Neighboring gene Sharpr-MPRA regulatory region 14595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103524373-103525023 Neighboring gene ribosomal protein L13 pseudogene 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103541151-103541742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6141 Neighboring gene LBH domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cargo receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cobalamin metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cobalamin transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in renal protein absorption IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in microvillus membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    protein amnionless
    Names
    amnionless homolog
    visceral endoderm-specific type 1 transmembrane protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008276.2 RefSeqGene

      Range
      5001..13187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_642

    mRNA and Protein(s)

    1. NM_001425246.1NP_001412175.1  protein amnionless isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL117209
      UniProtKB/TrEMBL
      B3KP64
    2. NM_030943.4NP_112205.2  protein amnionless isoform 1 precursor

      See identical proteins and their annotated locations for NP_112205.2

      Status: REVIEWED

      Source sequence(s)
      AF328788, AL117209, BC029948, CB306421
      Consensus CDS
      CCDS9977.1
      UniProtKB/Swiss-Prot
      Q6UX83, Q9BXJ7
      Related
      ENSP00000299155.6, ENST00000299155.10
      Conserved Domains (1) summary
      pfam14828
      Location:22447
      Amnionless

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      102922663..102930842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537202.4XP_011535504.1  protein amnionless isoform X1

      Conserved Domains (1) summary
      pfam14828
      Location:1393
      Amnionless; Amnionless
    2. XM_011537203.4XP_011535505.1  protein amnionless isoform X1

      See identical proteins and their annotated locations for XP_011535505.1

      UniProtKB/TrEMBL
      B3KP64
      Related
      ENST00000541086.5
      Conserved Domains (1) summary
      pfam14828
      Location:1393
      Amnionless; Amnionless

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      97158908..97167087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376773.1XP_054232748.1  protein amnionless isoform X1

    2. XM_054376774.1XP_054232749.1  protein amnionless isoform X1

      UniProtKB/TrEMBL
      B3KP64