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    ACSBG2 acyl-CoA synthetase bubblegum family member 2 [ Homo sapiens (human) ]

    Gene ID: 81616, updated on 17-Jun-2024

    Summary

    Official Symbol
    ACSBG2provided by HGNC
    Official Full Name
    acyl-CoA synthetase bubblegum family member 2provided by HGNC
    Primary source
    HGNC:HGNC:24174
    See related
    Ensembl:ENSG00000130377 MIM:614363; AllianceGenome:HGNC:24174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BGR; BRGL; PRTDNY3; PRTD-NY3
    Summary
    Enables acyl-CoA hydrolase activity and arachidonate-CoA ligase activity. Acts upstream of or within fatty acid metabolic process. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 79.4) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ACSBG2 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6135633..6193091)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6124368..6181277)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6135644..6193102)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9941 Neighboring gene RANBP3 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6015021-6015520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6018397-6018898 Neighboring gene regulatory factor X2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9943 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:6065893-6066394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6074378-6075171 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:6086791-6087292 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:6087293-6087792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6092583-6093288 Neighboring gene ribosomal protein L32 pseudogene 37 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6109025-6109525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9944 Neighboring gene uncharacterized LOC105372255 Neighboring gene Sharpr-MPRA regulatory region 9390 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:6134642-6135545 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:6135546-6136448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9945 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6198732-6199335 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr19:6199336-6199938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6216753-6217667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6227079-6227744 Neighboring gene Sharpr-MPRA regulatory region 3427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6239861-6240362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6243510-6244224 Neighboring gene MLLT1 super elongation complex subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6263043-6263544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6263545-6264044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6273107-6273706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6276605-6277105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9947 Neighboring gene alkaline ceramidase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC111089, DKFZp434K1635

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables arachidonate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fatty acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables very long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-chain fatty-acyl-CoA biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    long-chain-fatty-acid--CoA ligase ACSBG2
    Names
    arachidonate--CoA ligase ACSBG2
    bubblegum-related protein
    testicular tissue protein Li 8
    NP_001276106.1
    NP_001276107.1
    NP_001276108.1
    NP_001276109.1
    NP_001308313.1
    NP_112186.3
    XP_005259710.1
    XP_011526631.1
    XP_016882821.1
    XP_016882822.1
    XP_047295433.1
    XP_047295434.1
    XP_054178224.1
    XP_054178225.1
    XP_054178226.1
    XP_054178227.1
    XP_054178228.1
    XP_054178229.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289177.2NP_001276106.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform a

      See identical proteins and their annotated locations for NP_001276106.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 encode the same isoform.
      Source sequence(s)
      AK093433, AK302604, DB514968, HM005321, HY010944
      Consensus CDS
      CCDS12159.1
      UniProtKB/Swiss-Prot
      B3KSF2, Q5FVE4, Q6UWJ3, Q7Z5A0, Q8WW03, Q96M36, Q9BYZ3, Q9H0C4
      UniProtKB/TrEMBL
      A0A140VJD4, B4DYU1
      Related
      ENSP00000465589.1, ENST00000586696.5
      Conserved Domains (1) summary
      cd05933
      Location:73665
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    2. NM_001289178.2NP_001276107.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform a

      See identical proteins and their annotated locations for NP_001276107.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
      Source sequence(s)
      AJ577571, AK093433, BC090046, HY011431
      Consensus CDS
      CCDS12159.1
      UniProtKB/Swiss-Prot
      B3KSF2, Q5FVE4, Q6UWJ3, Q7Z5A0, Q8WW03, Q96M36, Q9BYZ3, Q9H0C4
      UniProtKB/TrEMBL
      A0A140VJD4, B4DYU1
      Related
      ENSP00000467755.1, ENST00000591403.5
      Conserved Domains (1) summary
      cd05933
      Location:73665
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    3. NM_001289179.2NP_001276108.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to isoform 1. The encoded isoform (b) is shorter, compared to isoform a.
      Source sequence(s)
      AK302604, DB514968, HM005321, HY010944
      Consensus CDS
      CCDS92498.1
      UniProtKB/TrEMBL
      A0A7P0Z4L8, B4DYU1
      Related
      ENSP00000506442.1, ENST00000681525.1
      Conserved Domains (2) summary
      cd05933
      Location:73637
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
      COG1022
      Location:51638
      FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
    4. NM_001289180.2NP_001276109.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AY009107, AY358766, DC399703, HM005321
      UniProtKB/Swiss-Prot
      Q5FVE4
      Conserved Domains (1) summary
      cl17068
      Location:3478
      AFD_class_I; Adenylate forming domain, Class I superfamily
    5. NM_001321384.2NP_001308313.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AY358766, HM005321
      Consensus CDS
      CCDS82282.1
      UniProtKB/TrEMBL
      B4DYU1
      Related
      ENSP00000464938.1, ENST00000588304.5
      Conserved Domains (2) summary
      cd05933
      Location:23615
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
      COG1022
      Location:1616
      FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
    6. NM_030924.5NP_112186.3  long-chain-fatty-acid--CoA ligase ACSBG2 isoform a

      See identical proteins and their annotated locations for NP_112186.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
      Source sequence(s)
      AK093433, BC090046, HY011431
      Consensus CDS
      CCDS12159.1
      UniProtKB/Swiss-Prot
      B3KSF2, Q5FVE4, Q6UWJ3, Q7Z5A0, Q8WW03, Q96M36, Q9BYZ3, Q9H0C4
      UniProtKB/TrEMBL
      A0A140VJD4, B4DYU1
      Related
      ENSP00000466336.2, ENST00000588485.6
      Conserved Domains (1) summary
      cd05933
      Location:73665
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      6135633..6193091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027333.2XP_016882822.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X2

      UniProtKB/TrEMBL
      B4DYU1
      Conserved Domains (2) summary
      cd05933
      Location:73642
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
      COG1022
      Location:51647
      FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
    2. XM_047439477.1XP_047295433.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X3

      UniProtKB/TrEMBL
      B4DYU1
    3. XM_005259653.4XP_005259710.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X4

      UniProtKB/TrEMBL
      B4DYU1
      Conserved Domains (2) summary
      pfam00501
      Location:57519
      AMP-binding; AMP-binding enzyme
      cl17068
      Location:73560
      AFD_class_I; Adenylate forming domain, Class I superfamily
    4. XM_017027332.3XP_016882821.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSF2, Q5FVE4, Q6UWJ3, Q7Z5A0, Q8WW03, Q96M36, Q9BYZ3, Q9H0C4
      UniProtKB/TrEMBL
      A0A140VJD4, B4DYU1
      Conserved Domains (1) summary
      cd05933
      Location:73665
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)
    5. XM_047439478.1XP_047295434.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X5

    6. XM_011528329.2XP_011526631.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X6

      Conserved Domains (1) summary
      cl17068
      Location:38458
      AFD_class_I; Adenylate forming domain, Class I superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      6124368..6181277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322250.1XP_054178225.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X2

      UniProtKB/TrEMBL
      B4DYU1
    2. XM_054322251.1XP_054178226.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X3

      UniProtKB/TrEMBL
      B4DYU1
    3. XM_054322252.1XP_054178227.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X4

      UniProtKB/TrEMBL
      B4DYU1
    4. XM_054322249.1XP_054178224.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1

      UniProtKB/TrEMBL
      B4DYU1
    5. XM_054322253.1XP_054178228.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X5

    6. XM_054322254.1XP_054178229.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X6