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    ANP32E acidic nuclear phosphoprotein 32 family member E [ Homo sapiens (human) ]

    Gene ID: 81611, updated on 23-Nov-2021

    Summary

    Official Symbol
    ANP32Eprovided by HGNC
    Official Full Name
    acidic nuclear phosphoprotein 32 family member Eprovided by HGNC
    Primary source
    HGNC:HGNC:16673
    See related
    Ensembl:ENSG00000143401 MIM:609611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LANPL; LANP-L
    Expression
    Ubiquitous expression in lymph node (RPKM 31.5), bone marrow (RPKM 21.4) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ANP32E in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (150218417..150236133, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150190717..150208460, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.8432 Neighboring gene RNA, 7SL, cytoplasmic 480, pseudogene Neighboring gene RNA, U2 small nuclear 17, pseudogene Neighboring gene carbonic anhydrase 14 Neighboring gene small nucleolar RNA, C/D box 13C

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Biological insights from 108 schizophrenia-associated genetic loci.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, acidic leucine-rich nuclear phosphoprotein 32 E (ANP32E), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with ANP32E is decreased by RRE PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human acidic (leucine-rich) nuclear phosphoprotein 32 family, member E (ANP32E) at amino acid residues 235-236 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC5350

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in histone exchange IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone exchange IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    acidic leucine-rich nuclear phosphoprotein 32 family member E
    Names
    LANP-like protein
    acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
    leucine-rich acidic nuclear protein like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136478.4NP_001129950.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC242988
      Consensus CDS
      CCDS44214.1
      UniProtKB/Swiss-Prot
      Q9BTT0
      Related
      ENSP00000393718.2, ENST00000436748.6
    2. NM_001136479.3NP_001129951.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 3

      See identical proteins and their annotated locations for NP_001129951.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC242988
      Consensus CDS
      CCDS44215.1
      UniProtKB/Swiss-Prot
      Q9BTT0
      Related
      ENSP00000481415.1, ENST00000616917.4
      Conserved Domains (2) summary
      sd00033
      Location:1841
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:598
      LRR_9; Leucine-rich repeat
    3. NM_001280559.2NP_001267488.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 4

      See identical proteins and their annotated locations for NP_001267488.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate splice site in the 3' coding region compared to variant 1. The resulting isoform (4) lacks an internal aa compared to isoform 1.
      Source sequence(s)
      AC242988
      UniProtKB/Swiss-Prot
      Q9BTT0
      Conserved Domains (2) summary
      sd00033
      Location:4465
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:34146
      LRR_9; Leucine-rich repeat
    4. NM_001280560.2NP_001267489.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two internal exons compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC242988
      Consensus CDS
      CCDS60245.1
      UniProtKB/Swiss-Prot
      Q9BTT0
      UniProtKB/TrEMBL
      B4E0D5, E9PLC4
      Related
      ENSP00000435215.1, ENST00000533654.5
      Conserved Domains (2) summary
      sd00033
      Location:4465
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:65107
      LRR_4; Leucine Rich repeats (2 copies)
    5. NM_030920.5NP_112182.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1

      See identical proteins and their annotated locations for NP_112182.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC242988
      Consensus CDS
      CCDS946.1
      UniProtKB/Swiss-Prot
      Q9BTT0
      Related
      ENSP00000463154.1, ENST00000583931.6
      Conserved Domains (2) summary
      sd00033
      Location:4465
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:34146
      LRR_9; Leucine-rich repeat

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      150218417..150236133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245514.4XP_005245571.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X3

      See identical proteins and their annotated locations for XP_005245571.1

      Conserved Domains (4) summary
      cd00116
      Location:15146
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:4465
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:88130
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:65125
      LRR_8; Leucine rich repeat
    2. XM_017002418.2XP_016857907.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X2

    3. XM_005245513.4XP_005245570.1  acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X1

      Conserved Domains (3) summary
      cd09293
      Location:53126
      AMN1; Antagonist of mitotic exit network protein 1
      sd00033
      Location:4465
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:65125
      LRR_8; Leucine rich repeat
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