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    PDRG1 p53 and DNA damage regulated 1 [ Homo sapiens (human) ]

    Gene ID: 81572, updated on 17-Jun-2024

    Summary

    Official Symbol
    PDRG1provided by HGNC
    Official Full Name
    p53 and DNA damage regulated 1provided by HGNC
    Primary source
    HGNC:HGNC:16119
    See related
    Ensembl:ENSG00000088356 MIM:610789; AllianceGenome:HGNC:16119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDRG; C20orf126
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm. Predicted to be part of prefoldin complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 24.8), placenta (RPKM 9.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PDRG1 in Genome Data Viewer
    Location:
    20q11.21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (31944337..31952046, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (33668974..33676683, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30532140..30539849, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17701 Neighboring gene dual specificity phosphatase 15 Neighboring gene forkhead box S1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12767 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30467121-30467620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12770 Neighboring gene tubulin tyrosine ligase like 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17702 Neighboring gene Sharpr-MPRA regulatory region 918 Neighboring gene RNA, U1 small nuclear 94, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17704 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:30556227-30556404 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30559879-30560380 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30560381-30560880 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30564043-30564544 Neighboring gene XK related 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30575890-30576724 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30576725-30577558 Neighboring gene RNA, 5S ribosomal pseudogene 481

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RPAP3/R2TP/prefoldin-like complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein folding chaperone complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    p53 and DNA damage-regulated protein 1
    Names
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030815.3NP_110442.1  p53 and DNA damage-regulated protein 1

      See identical proteins and their annotated locations for NP_110442.1

      Status: VALIDATED

      Source sequence(s)
      AL031658, AY286301, BC009334, BM679702
      Consensus CDS
      CCDS13194.1
      UniProtKB/Swiss-Prot
      B2R511, Q96GP3, Q9BUW8, Q9NUG6
      UniProtKB/TrEMBL
      A0A384NKN4
      Related
      ENSP00000202017.4, ENST00000202017.6
      Conserved Domains (1) summary
      cl09111
      Location:27108
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      31944337..31952046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      33668974..33676683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)