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    OR51E2 olfactory receptor family 51 subfamily E member 2 [ Homo sapiens (human) ]

    Gene ID: 81285, updated on 11-Apr-2024

    Summary

    Official Symbol
    OR51E2provided by HGNC
    Official Full Name
    olfactory receptor family 51 subfamily E member 2provided by HGNC
    Primary source
    HGNC:HGNC:15195
    See related
    Ensembl:ENSG00000167332 MIM:611268; AllianceGenome:HGNC:15195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSGR; HPRAJ; OR52A2; OR51E3P
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 29.8) and placenta (RPKM 2.3) See more
    Orthologs
    NEW
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    Genomic context

    Location:
    11p15.4
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (4680171..4697853, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (4745678..4763359, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (4701401..4719083, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376528 Neighboring gene olfactory receptor family 51 subfamily A member 9 pseudogene Neighboring gene olfactory receptor family 51 subfamily C member 1 pseudogene Neighboring gene olfactory receptor family 51 subfamily F member 5 pseudogene Neighboring gene matrix metallopeptidase 26 Neighboring gene olfactory receptor family 51 subfamily C member 4 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear steroid receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables olfactory receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables olfactory receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    olfactory receptor 51E2
    Names
    olfactory receptor OR11-16
    olfactory receptor, family 51, subfamily E, member 3 pseudogene
    olfactory receptor, family 52, subfamily A, member 2
    prostate-specific G-protein coupled receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030774.4NP_110401.1  olfactory receptor 51E2

      See identical proteins and their annotated locations for NP_110401.1

      Status: VALIDATED

      Source sequence(s)
      AC090719, AK314051
      Consensus CDS
      CCDS7751.1
      UniProtKB/Swiss-Prot
      B2RA63, Q6IF94, Q9H255
      UniProtKB/TrEMBL
      A0A126GVK0
      Related
      ENSP00000380153.3, ENST00000396950.4
      Conserved Domains (1) summary
      cd15222
      Location:24298
      7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      4680171..4697853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      4745678..4763359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)