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    DPF3 double PHD fingers 3 [ Homo sapiens (human) ]

    Gene ID: 8110, updated on 17-Jun-2024

    Summary

    Official Symbol
    DPF3provided by HGNC
    Official Full Name
    double PHD fingers 3provided by HGNC
    Primary source
    HGNC:HGNC:17427
    See related
    Ensembl:ENSG00000205683 MIM:601672; AllianceGenome:HGNC:17427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CERD4; BAF45C; SMARCG3
    Summary
    This gene encodes a member of the D4 protein family. The encoded protein is a transcription regulator that binds acetylated histones and is a component of the BAF chromatin remodeling complex. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
    Expression
    Biased expression in ovary (RPKM 2.9), heart (RPKM 2.2) and 11 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DPF3 in Genome Data Viewer
    Location:
    14q24.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (72609034..72894101, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (66814656..67099787, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (73075742..73360809, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene regulator of G protein signaling 6 Neighboring gene uncharacterized LOC105370559 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72917516-72918293 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:72923240-72923442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8683 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:72981479-72981979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:73011529-73012307 Neighboring gene microRNA 7843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73066667-73067182 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:73085384-73086583 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:73087954-73088634 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:73109733-73110932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73118269-73119105 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73146128-73146975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73174572-73175072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:73208790-73209747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73257468-73257968 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:73276522-73277721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73318647-73319224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8689 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:73331388-73331571 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73342399-73343100 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:73343101-73343801 Neighboring gene MPRA-validated peak2194 silencer Neighboring gene Sharpr-MPRA regulatory region 237 Neighboring gene uncharacterized LOC107984711 Neighboring gene uncharacterized LOC124903429

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14079

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SWI/SNF complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of brahma complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of chromatin NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of nBAF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of nBAF complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    zinc finger protein DPF3
    Names
    BRG1-associated factor 45C
    D4, zinc and double PHD fingers, family 3
    zinc finger protein cer-d4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001280542.3NP_001267471.1  zinc finger protein DPF3 isoform 2

      See identical proteins and their annotated locations for NP_001267471.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' CDS and the 3' UTR compared to variant 1. The encoded isoform (2, also known as DPF3b) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      AC004828, AC006360, AC007160, AL392024
      Consensus CDS
      CCDS61497.1
      UniProtKB/Swiss-Prot
      A8MSI3, B7Z276, F5H575, Q32UJ0, Q6P9E6, Q6ZT41, Q92784, Q9H7Y5
      Related
      ENSP00000450518.1, ENST00000556509.6
      Conserved Domains (4) summary
      COG5189
      Location:195222
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      cd15530
      Location:318363
      PHD2_d4; PHD finger 2 found in d4 gene family proteins
      cd15692
      Location:261317
      PHD1_DPF3; PHD finger 1 found in D4, zinc and double PHD fingers family 3 (DPF3)
      pfam14051
      Location:1379
      Requiem_N; N-terminal domain of DPF2/REQ
    2. NM_001280543.2NP_001267472.1  zinc finger protein DPF3 isoform 3

      See identical proteins and their annotated locations for NP_001267472.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC004828, AK123045, AK126074, AK294425, BC026305, DB172058
      Consensus CDS
      CCDS61495.1
      UniProtKB/Swiss-Prot
      Q92784
      Related
      ENSP00000481992.1, ENST00000614862.5
      Conserved Domains (2) summary
      pfam14051
      Location:2394
      Requiem_N; N-terminal domain of DPF2/REQ
      cl22851
      Location:271302
      PHD_SF; PHD finger superfamily
    3. NM_001280544.2NP_001267473.1  zinc finger protein DPF3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC004828, AC007160, AK124946, AK126933, BC026305
      Consensus CDS
      CCDS61496.1
      UniProtKB/TrEMBL
      F8W7T1
      Related
      ENSP00000381791.3, ENST00000366353.8
      Conserved Domains (2) summary
      pfam14051
      Location:68139
      Requiem_N; N-terminal domain of DPF2/REQ
      cl22851
      Location:316347
      PHD_SF; PHD finger superfamily
    4. NM_012074.5NP_036206.3  zinc finger protein DPF3 isoform 1

      See identical proteins and their annotated locations for NP_036206.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shortest isoform (1, also known as DPF3a).
      Source sequence(s)
      AC004828, AK126933, BC026305, BC060801
      Consensus CDS
      CCDS45133.1
      UniProtKB/Swiss-Prot
      Q92784
      Related
      ENSP00000370614.4, ENST00000381216.8
      Conserved Domains (3) summary
      COG5189
      Location:195222
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      pfam14051
      Location:1379
      Requiem_N; N-terminal domain of DPF2/REQ
      cl22851
      Location:261292
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      72609034..72894101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      66814656..67099787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)