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    Dusp12 dual specificity phosphatase 12 [ Mus musculus (house mouse) ]

    Gene ID: 80915, updated on 23-May-2018

    Summary

    Official Symbol
    Dusp12provided by MGI
    Official Full Name
    dual specificity phosphatase 12provided by MGI
    Primary source
    MGI:MGI:1890614
    See related
    Ensembl:ENSMUSG00000026659 Vega:OTTMUSG00000035839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    VH1; mVH1; ESTM36; T-DSP4; AA027408; AW049275; LMW-DSP4; 1190004O14Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 13.9), CNS E18 (RPKM 12.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dusp12 in Genome Data Viewer
    Location:
    1; 1 H3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (170874187..170885878, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (172804319..172815671, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene olfactomedin-like 2B Neighboring gene activating transcription factor 6 Neighboring gene predicted gene, 29733 Neighboring gene Fc receptor-like B Neighboring gene Fc receptor-like A Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117646

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine/serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine/serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of glucokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dual specificity protein phosphatase 12
    Names
    dual specificity phosphatase T-DSP4
    dual specificity phosphatase VH1
    NP_075662.2
    XP_006497105.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356485.1NP_001343414.1  dual specificity protein phosphatase 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113490
      Conserved Domains (1) summary
      cd00127
      Location:26165
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    2. NM_001356486.1NP_001343415.1  dual specificity protein phosphatase 12 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113490
      Conserved Domains (1) summary
      cl21483
      Location:140
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. NM_023173.2NP_075662.2  dual specificity protein phosphatase 12 isoform 1

      See identical proteins and their annotated locations for NP_075662.2

      Status: VALIDATED

      Source sequence(s)
      BC099453
      Consensus CDS
      CCDS15474.1
      UniProtKB/Swiss-Prot
      Q9D0T2
      UniProtKB/TrEMBL
      Q4KL39
      Related
      ENSMUSP00000027970.7, OTTMUSP00000050593, ENSMUST00000027970.13, OTTMUST00000091798
      Conserved Domains (1) summary
      cd00127
      Location:26165
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    RNA

    1. NR_151476.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113490
    2. NR_151477.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113490

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      170874187..170885878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497042.1XP_006497105.1  dual specificity protein phosphatase 12 isoform X1

      Conserved Domains (1) summary
      cl21483
      Location:140
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RNA

    1. XR_373626.3 RNA Sequence

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