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    Pum1 pumilio RNA-binding family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 80912, updated on 11-Jul-2021

    Summary

    Official Symbol
    Pum1provided by MGI
    Official Full Name
    pumilio RNA-binding family member 1provided by MGI
    Primary source
    MGI:MGI:1931749
    See related
    Ensembl:ENSMUSG00000028580
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pum; Pumm; AA517475; mKIAA0099
    Expression
    Ubiquitous expression in ovary adult (RPKM 32.2), whole brain E14.5 (RPKM 27.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pum1 in Genome Data Viewer
    Location:
    4; 4 D2.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130390509..130508875)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130663238..130781564)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (130219274..130337479)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Na+/K+ transporting ATPase interacting 1 Neighboring gene predicted gene, 53228 Neighboring gene small nucleolar RNA, C/D box 85 Neighboring gene predicted gene, 24091 Neighboring gene predicted gene, 23711 Neighboring gene predicted gene 12972 Neighboring gene syndecan 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (3) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in posttranscriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in posttranscriptional regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within posttranscriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within posttranscriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in posttranscriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in production of miRNAs involved in gene silencing by miRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in production of miRNAs involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pumilio homolog 1
    Names
    pumilio 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159603.2NP_001153075.1  pumilio homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_001153075.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses multiple alternate in-frame splice sites, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK162742, BE653001, BU708930, BY782432, CB724122, CF157665, CF746520, CJ064695, CJ227969, CN530452, CN530471, CN538180, CN724656, CV559585
      Consensus CDS
      CCDS51311.1
      UniProtKB/Swiss-Prot
      Q80U78
      Related
      ENSMUSP00000095476.3, ENSMUST00000097864.9
      Conserved Domains (1) summary
      cd07920
      Location:8431164
      Pumilio; Pumilio-family RNA binding domain
    2. NM_001159604.2NP_001153076.1  pumilio homolog 1 isoform 3

      See identical proteins and their annotated locations for NP_001153076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site, compared to variant 1, which results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AK161135, AK162742, BC048174, BY782432, CF746520, CJ227969
      Consensus CDS
      CCDS51312.1
      UniProtKB/Swiss-Prot
      Q80U78
      UniProtKB/TrEMBL
      Q3TQ21
      Related
      ENSMUSP00000095474.3, ENSMUST00000097862.3
      Conserved Domains (1) summary
      cd07920
      Location:8431166
      Pumilio; Pumilio-family RNA binding domain
    3. NM_001159605.2NP_001153077.1  pumilio homolog 1 isoform 4

      See identical proteins and their annotated locations for NP_001153077.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple coding region differences, compared to variant 1, which results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AK161135, AK162742, BY782432, CF746520, CJ227969
      Consensus CDS
      CCDS51313.1
      UniProtKB/TrEMBL
      Q3TTW5
      Related
      ENSMUSP00000101613.3, ENSMUST00000105992.9
      Conserved Domains (1) summary
      cd07920
      Location:7471070
      Pumilio; Pumilio-family RNA binding domain
    4. NM_001159606.2NP_001153078.1  pumilio homolog 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple coding region differences, compared to variant 1, which results in a shorter protein (isoform 5), compared to isoform 1.
      Source sequence(s)
      AK147185, AK161135, AK162742, BY782432, CF746520, CJ227969, CN526490
      Consensus CDS
      CCDS51314.1
      UniProtKB/TrEMBL
      E9Q6M7
      Related
      ENSMUSP00000101612.3, ENSMUST00000105991.9
      Conserved Domains (1) summary
      cd07920
      Location:601922
      Pumilio; Pumilio-family RNA binding domain
    5. NM_001356564.1NP_001343493.1  pumilio homolog 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AK162742, AL627104, CF746520, CJ227969
      Conserved Domains (1) summary
      cd07920
      Location:7651086
      Pumilio; Pumilio-family RNA binding domain
    6. NM_001356565.1NP_001343494.1  pumilio homolog 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AK162742, AL627104, BY782432, CF746520, CJ227969, CN456820, CN724656, CV559585
      Conserved Domains (1) summary
      cd07920
      Location:7471068
      Pumilio; Pumilio-family RNA binding domain
    7. NM_001356566.1NP_001343495.1  pumilio homolog 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AK162742, AL627104, BE653001, BY782432, CF746520, CJ093090, CJ227969, CN724656, CV559585
      Conserved Domains (1) summary
      cd07920
      Location:601924
      Pumilio; Pumilio-family RNA binding domain
    8. NM_030722.3NP_109647.2  pumilio homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_109647.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK162742, BE653001, BU708930, BY782432, CB724122, CF746520, CJ064695, CJ227969, CN530452, CN530471, CN538180, CN724656
      Consensus CDS
      CCDS18710.1
      UniProtKB/Swiss-Prot
      Q80U78
      Related
      ENSMUSP00000030315.7, ENSMUST00000030315.13
      Conserved Domains (1) summary
      cd07920
      Location:8441167
      Pumilio; Pumilio-family RNA binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      130390509..130508875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539291.5XP_006539354.1  pumilio homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006539354.1

      Conserved Domains (1) summary
      cd07920
      Location:8481171
      Pumilio; Pumilio-family RNA binding domain
    2. XM_006539294.5XP_006539357.1  pumilio homolog 1 isoform X3

      See identical proteins and their annotated locations for XP_006539357.1

      Conserved Domains (1) summary
      cd07920
      Location:8481169
      Pumilio; Pumilio-family RNA binding domain
    3. XM_006539296.5XP_006539359.1  pumilio homolog 1 isoform X10

      See identical proteins and their annotated locations for XP_006539359.1

      Conserved Domains (1) summary
      cd07920
      Location:7691092
      Pumilio; Pumilio-family RNA binding domain
    4. XM_006539297.5XP_006539360.1  pumilio homolog 1 isoform X11

      See identical proteins and their annotated locations for XP_006539360.1

      Conserved Domains (1) summary
      cd07920
      Location:7691090
      Pumilio; Pumilio-family RNA binding domain
    5. XM_017320459.3XP_017175948.1  pumilio homolog 1 isoform X6

      Conserved Domains (1) summary
      cd07920
      Location:8441165
      Pumilio; Pumilio-family RNA binding domain
    6. XM_006539295.5XP_006539358.1  pumilio homolog 1 isoform X8

      See identical proteins and their annotated locations for XP_006539358.1

      Conserved Domains (1) summary
      cd07920
      Location:8091132
      Pumilio; Pumilio-family RNA binding domain
    7. XM_030253924.2XP_030109784.1  pumilio homolog 1 isoform X9

      Conserved Domains (1) summary
      cd07920
      Location:8091130
      Pumilio; Pumilio-family RNA binding domain
    8. XM_036164565.1XP_036020458.1  pumilio homolog 1 isoform X21

      Conserved Domains (1) summary
      cd07920
      Location:7301053
      Pumilio; Pumilio-family RNA binding domain
    9. XM_030253933.2XP_030109793.1  pumilio homolog 1 isoform X32

      Conserved Domains (1) summary
      cd07920
      Location:7301051
      Pumilio; Pumilio-family RNA binding domain
    10. XM_006539303.5XP_006539366.1  pumilio homolog 1 isoform X31

      See identical proteins and their annotated locations for XP_006539366.1

      Conserved Domains (1) summary
      cd07920
      Location:659982
      Pumilio; Pumilio-family RNA binding domain
    11. XM_006539293.5XP_006539356.1  pumilio homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_006539356.1

      Conserved Domains (1) summary
      cd07920
      Location:8471170
      Pumilio; Pumilio-family RNA binding domain
    12. XM_030253922.2XP_030109782.1  pumilio homolog 1 isoform X5

      Conserved Domains (1) summary
      cd07920
      Location:8431166
      Pumilio; Pumilio-family RNA binding domain
    13. XM_036164562.1XP_036020455.1  pumilio homolog 1 isoform X15

      Conserved Domains (1) summary
      cd07920
      Location:8431164
      Pumilio; Pumilio-family RNA binding domain
    14. XM_030253923.2XP_030109783.1  pumilio homolog 1 isoform X7

      Conserved Domains (1) summary
      cd07920
      Location:8421165
      Pumilio; Pumilio-family RNA binding domain
    15. XM_036164564.1XP_036020457.1  pumilio homolog 1 isoform X17

      Conserved Domains (1) summary
      cd07920
      Location:8421163
      Pumilio; Pumilio-family RNA binding domain
    16. XM_006539299.5XP_006539362.1  pumilio homolog 1 isoform X18

      See identical proteins and their annotated locations for XP_006539362.1

      Conserved Domains (1) summary
      cd07920
      Location:7521075
      Pumilio; Pumilio-family RNA binding domain
    17. XM_030253931.2XP_030109791.1  pumilio homolog 1 isoform X28

      Conserved Domains (1) summary
      cd07920
      Location:7521073
      Pumilio; Pumilio-family RNA binding domain
    18. XM_030253925.2XP_030109785.1  pumilio homolog 1 isoform X19

      Conserved Domains (1) summary
      cd07920
      Location:7481071
      Pumilio; Pumilio-family RNA binding domain
    19. XM_030253926.2XP_030109786.1  pumilio homolog 1 isoform X20

      Conserved Domains (1) summary
      cd07920
      Location:7481069
      Pumilio; Pumilio-family RNA binding domain
    20. XM_036164568.1XP_036020461.1  pumilio homolog 1 isoform X29

      Conserved Domains (1) summary
      cd07920
      Location:669992
      Pumilio; Pumilio-family RNA binding domain
    21. XM_036164569.1XP_036020462.1  pumilio homolog 1 isoform X30

      Conserved Domains (1) summary
      cd07920
      Location:668989
      Pumilio; Pumilio-family RNA binding domain
    22. XM_030253928.2XP_030109788.1  pumilio homolog 1 isoform X26

      Conserved Domains (1) summary
      cd07920
      Location:7131036
      Pumilio; Pumilio-family RNA binding domain
    23. XM_006539308.4XP_006539371.1  pumilio homolog 1 isoform X36

      See identical proteins and their annotated locations for XP_006539371.1

      Conserved Domains (1) summary
      cd07920
      Location:606929
      Pumilio; Pumilio-family RNA binding domain
    24. XM_036164573.1XP_036020466.1  pumilio homolog 1 isoform X37

      Conserved Domains (1) summary
      cd07920
      Location:606927
      Pumilio; Pumilio-family RNA binding domain
    25. XM_006539309.4XP_006539372.1  pumilio homolog 1 isoform X38

      See identical proteins and their annotated locations for XP_006539372.1

      Conserved Domains (1) summary
      cd07920
      Location:602925
      Pumilio; Pumilio-family RNA binding domain
    26. XM_006539300.5XP_006539363.1  pumilio homolog 1 isoform X22

      See identical proteins and their annotated locations for XP_006539363.1

      Conserved Domains (1) summary
      cd07920
      Location:7281051
      Pumilio; Pumilio-family RNA binding domain
    27. XM_030253927.2XP_030109787.1  pumilio homolog 1 isoform X24

      Conserved Domains (1) summary
      cd07920
      Location:7241047
      Pumilio; Pumilio-family RNA binding domain
    28. XM_036164567.1XP_036020460.1  pumilio homolog 1 isoform X27

      Conserved Domains (1) summary
      cd07920
      Location:7241045
      Pumilio; Pumilio-family RNA binding domain
    29. XM_030253930.2XP_030109790.1  pumilio homolog 1 isoform X25

      Conserved Domains (1) summary
      cd07920
      Location:7231046
      Pumilio; Pumilio-family RNA binding domain
    30. XM_036164572.1XP_036020465.1  pumilio homolog 1 isoform X35

      Conserved Domains (1) summary
      cd07920
      Location:644967
      Pumilio; Pumilio-family RNA binding domain
    31. XM_006539301.5XP_006539364.1  pumilio homolog 1 isoform X23

      See identical proteins and their annotated locations for XP_006539364.1

      Conserved Domains (1) summary
      cd07920
      Location:7271050
      Pumilio; Pumilio-family RNA binding domain
    32. XM_036164571.1XP_036020464.1  pumilio homolog 1 isoform X34

      Conserved Domains (1) summary
      cd07920
      Location:627950
      Pumilio; Pumilio-family RNA binding domain
    33. XM_006539314.5XP_006539377.1  pumilio homolog 1 isoform X39

      See identical proteins and their annotated locations for XP_006539377.1

      Conserved Domains (1) summary
      cd07920
      Location:486809
      Pumilio; Pumilio-family RNA binding domain
    34. XM_036164574.1XP_036020467.1  pumilio homolog 1 isoform X40

      Conserved Domains (1) summary
      cd07920
      Location:481804
      Pumilio; Pumilio-family RNA binding domain
    35. XM_006539292.4XP_006539355.1  pumilio homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006539355.1

      Conserved Domains (1) summary
      cd07920
      Location:8481171
      Pumilio; Pumilio-family RNA binding domain
    36. XM_036164561.1XP_036020454.1  pumilio homolog 1 isoform X4

      Conserved Domains (1) summary
      cd07920
      Location:8441167
      Pumilio; Pumilio-family RNA binding domain
    37. XM_017320461.3XP_017175950.1  pumilio homolog 1 isoform X13

      Conserved Domains (1) summary
      cd07920
      Location:7641087
      Pumilio; Pumilio-family RNA binding domain
    38. XM_017320463.2XP_017175952.1  pumilio homolog 1 isoform X16

      Conserved Domains (1) summary
      cd07920
      Location:7641085
      Pumilio; Pumilio-family RNA binding domain
    39. XM_017320460.3XP_017175949.1  pumilio homolog 1 isoform X12

      Conserved Domains (1) summary
      cd07920
      Location:7651088
      Pumilio; Pumilio-family RNA binding domain
    40. XM_017320462.3XP_017175951.1  pumilio homolog 1 isoform X14

      Conserved Domains (1) summary
      cd07920
      Location:7651086
      Pumilio; Pumilio-family RNA binding domain
    41. XM_036164566.1XP_036020459.1  pumilio homolog 1 isoform X24

      Conserved Domains (1) summary
      cd07920
      Location:7241047
      Pumilio; Pumilio-family RNA binding domain
    42. XM_036164570.1XP_036020463.1  pumilio homolog 1 isoform X33

      Conserved Domains (1) summary
      cd07920
      Location:632955
      Pumilio; Pumilio-family RNA binding domain
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