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    YEATS4 YEATS domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 8089, updated on 7-Oct-2018

    Summary

    Official Symbol
    YEATS4provided by HGNC
    Official Full Name
    YEATS domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:24859
    See related
    Ensembl:ENSG00000127337 MIM:602116; Vega:OTTHUMG00000169358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik
    Summary
    The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in testis (RPKM 7.3), bone marrow (RPKM 4.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See YEATS4 in Genome Data Viewer
    Location:
    12q15
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (69359705..69427077)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (69753490..69784576)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 pseudogene 1 Neighboring gene lysozyme Neighboring gene RNA, 7SL, cytoplasmic 804, pseudogene Neighboring gene ribosomal protein S26 pseudogene 45 Neighboring gene long intergenic non-protein coding RNA 2373 Neighboring gene fibroblast growth factor receptor substrate 2 Neighboring gene small nucleolar RNA, H/ACA box 113

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
    NHGRI GWA Catalog
    Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.
    NHGRI GWA Catalog
    Many sequence variants affecting diversity of adult human height.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Activation of the TFAP2 (AP-2) family of transcription factors, organism-specific biosystem (from REACTOME)
      Activation of the TFAP2 (AP-2) family of transcription factors, organism-specific biosystemThe helix-span-helix motif and the basic region of TFAP2 (AP-2) transcription factor family members TFAP2A, TFAP2B, TFAP2C, TFAP2D and TFAP2E enable dimerization and DNA binding. AP-2 dimers bind pal...
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
      Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
    • Chromatin organization, organism-specific biosystem (from REACTOME)
      Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • HATs acetylate histones, organism-specific biosystem (from REACTOME)
      HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
    • Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, organism-specific biosystem (from REACTOME)
      Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, organism-specific biosystemThe AP-2 (TFAP2) family of transcription factors includes five proteins in mammals: TFAP2A (AP-2 alpha), TFAP2B (AP-2 beta), TFAP2C (AP-2 gamma), TFAP2D (AP-2 delta) and TFAP2E (AP-2 epsilon). The AP...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H2A acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H4 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
     
    positive regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Swr1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear matrix NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    YEATS domain-containing protein 4
    Names
    NuMA binding protein 1
    glioma-amplified sequence 41
    nuBI1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052956.1 RefSeqGene

      Range
      5001..36161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300950.1NP_001287879.1  YEATS domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001287879.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BC000994, CA775118, CK820576, DN915967, U61384
      Consensus CDS
      CCDS73495.1
      UniProtKB/Swiss-Prot
      O95619
      UniProtKB/TrEMBL
      F8W0J4
      Related
      ENSP00000447199.1, OTTHUMP00000240880, ENST00000548020.5, OTTHUMT00000403664
    2. NM_006530.3NP_006521.1  YEATS domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_006521.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC117502, CK820576, DN915967, U61384
      Consensus CDS
      CCDS8990.1
      UniProtKB/Swiss-Prot
      O95619
      Related
      ENSP00000247843.2, OTTHUMP00000240879, ENST00000247843.6, OTTHUMT00000403663
      Conserved Domains (1) summary
      pfam03366
      Location:44123
      YEATS; YEATS family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      69359705..69427077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_944742.3 RNA Sequence

    2. XR_001748876.1 RNA Sequence

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