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    Senp3 SUMO/sentrin specific peptidase 3 [ Mus musculus (house mouse) ]

    Gene ID: 80886, updated on 12-Sep-2021

    Summary

    Official Symbol
    Senp3provided by MGI
    Official Full Name
    SUMO/sentrin specific peptidase 3provided by MGI
    Primary source
    MGI:MGI:2158736
    See related
    Ensembl:ENSMUSG00000005204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Smt3; Smt3ip; Smt3ip1; AA408656
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 28.8), CNS E18 (RPKM 23.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Senp3 in Genome Data Viewer
    Location:
    11; 11 B3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69563936..69572910, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69673110..69682084, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69486612..69495586, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A1 Neighboring gene predicted gene, 25835 Neighboring gene predicted gene, 22988 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13, opposite strand Neighboring gene tumor necrosis factor (ligand) superfamily, membrane-bound member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO-specific isopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thiol-dependent deubiquitinase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein desumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    sentrin-specific protease 3
    Names
    SUMO-1-specific protease 3
    SUMO/sentrin specific protease 3
    sentrin/SUMO-specific protease SENP3
    smt3-specific isopeptidase 1
    NP_001157043.1
    NP_109627.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163571.1NP_001157043.1  sentrin-specific protease 3

      See identical proteins and their annotated locations for NP_001157043.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL603707
      Consensus CDS
      CCDS24905.1
      UniProtKB/Swiss-Prot
      Q9EP97
      Related
      ENSMUSP00000066581.2, ENSMUST00000066760.8
      Conserved Domains (1) summary
      pfam02902
      Location:394566
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    2. NM_030702.4NP_109627.3  sentrin-specific protease 3

      See identical proteins and their annotated locations for NP_109627.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK045071, AY008764, BY134888
      Consensus CDS
      CCDS24905.1
      UniProtKB/Swiss-Prot
      Q9EP97
      Related
      ENSMUSP00000005336.3, ENSMUST00000005336.9
      Conserved Domains (1) summary
      pfam02902
      Location:394566
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69563936..69572910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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