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    Senp3 SUMO/sentrin specific peptidase 3 [ Mus musculus (house mouse) ]

    Gene ID: 80886, updated on 5-Aug-2018

    Summary

    Official Symbol
    Senp3provided by MGI
    Official Full Name
    SUMO/sentrin specific peptidase 3provided by MGI
    Primary source
    MGI:MGI:2158736
    See related
    Ensembl:ENSMUSG00000005204 Vega:OTTMUSG00000006011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Smt3ip; Smt3ip1; AA408656
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 28.8), CNS E18 (RPKM 23.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Senp3 in Genome Data Viewer
    Location:
    11; 11 B3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (69673110..69682084, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69486612..69495586, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene CD68 antigen Neighboring gene eukaryotic translation initiation factor 4A1 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13, opposite strand Neighboring gene tumor necrosis factor (ligand) superfamily, membrane-bound member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sentrin-specific protease 3
    Names
    SUMO-1-specific protease 3
    SUMO/sentrin specific protease 3
    sentrin/SUMO-specific protease SENP3
    smt3-specific isopeptidase 1
    NP_001157043.1
    NP_109627.3
    XP_006534593.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163571.1NP_001157043.1  sentrin-specific protease 3

      See identical proteins and their annotated locations for NP_001157043.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL603707
      Consensus CDS
      CCDS24905.1
      UniProtKB/Swiss-Prot
      Q9EP97
      Related
      ENSMUSP00000066581.1, OTTMUSP00000006236, ENSMUST00000066760.7, OTTMUST00000013468
      Conserved Domains (1) summary
      pfam02902
      Location:394566
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    2. NM_030702.4NP_109627.3  sentrin-specific protease 3

      See identical proteins and their annotated locations for NP_109627.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK045071, AY008764, BY134888
      Consensus CDS
      CCDS24905.1
      UniProtKB/Swiss-Prot
      Q9EP97
      Related
      ENSMUSP00000005336.2, OTTMUSP00000006235, ENSMUST00000005336.8, OTTMUST00000013467
      Conserved Domains (1) summary
      pfam02902
      Location:394566
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      69673110..69682084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534530.2XP_006534593.1  sentrin-specific protease 3 isoform X1

      Conserved Domains (1) summary
      pfam02902
      Location:394549
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
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