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    Lrba LPS-responsive beige-like anchor [ Mus musculus (house mouse) ]

    Gene ID: 80877, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lrbaprovided by MGI
    Official Full Name
    LPS-responsive beige-like anchorprovided by MGI
    Primary source
    MGI:MGI:1933162
    See related
    Ensembl:ENSMUSG00000028080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L; Lba; C80285; Lab300; D3Ertd775; D3Ertd775e
    Expression
    Ubiquitous expression in kidney adult (RPKM 5.1), large intestine adult (RPKM 4.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lrba in Genome Data Viewer
    Location:
    3; 3 F1
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (86130763..86690001)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (86223456..86782694)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (86028612..86586616)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box U73B Neighboring gene ribosomal protein S3A1 Neighboring gene predicted gene, 23025 Neighboring gene predicted gene, 26343 Neighboring gene predicted gene, 40083 Neighboring gene predicted gene, 23850 Neighboring gene predicted gene, 25039 Neighboring gene predicted gene, 31677 Neighboring gene mab-21-like 2 Neighboring gene thymosin, beta 10 pseudogene Neighboring gene predicted gene, 52625 Neighboring gene doublecortin-like kinase 2 Neighboring gene predicted gene, 46810 Neighboring gene predicted gene, 23376

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase A binding ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lipopolysaccharide-responsive and beige-like anchor protein
    Names
    beige-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077687.1NP_001071155.1  lipopolysaccharide-responsive and beige-like anchor protein isoform gamma

      Status: VALIDATED

      Source sequence(s)
      AC102270, AF187731, AF188507, AK035483, AK052148, CV556905
      Consensus CDS
      CCDS79934.1
      UniProtKB/Swiss-Prot
      Q9ESE1
      UniProtKB/TrEMBL
      A0A0A6YXX3, Q8C7C2, Q8CBR4
      Related
      ENSMUSP00000142179.2, ENSMUST00000192145.6
      Conserved Domains (6) summary
      cd00020
      Location:672790
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam02138
      Location:22042480
      Beach; Beige/BEACH domain
      pfam06469
      Location:18822049
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:20752172
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:446717
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:229376
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    2. NM_001077688.1NP_001071156.1  lipopolysaccharide-responsive and beige-like anchor protein isoform beta

      Status: VALIDATED

      Source sequence(s)
      AC102164, AC102270, AF187731, AF188506, AF188507, AK052148, CV556905
      Consensus CDS
      CCDS79933.1
      UniProtKB/Swiss-Prot
      Q9ESE1
      UniProtKB/TrEMBL
      A0A0A6YXL6, Q8C7C2
      Related
      ENSMUSP00000142043.2, ENSMUST00000194759.6
      Conserved Domains (9) summary
      COG2319
      Location:25382775
      WD40; WD40 repeat [General function prediction only]
      cd00020
      Location:672790
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam02138
      Location:22042480
      Beach; Beige/BEACH domain
      pfam06469
      Location:18822049
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:20752172
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:446717
      DUF4704; Domain of unknown function (DUF4704)
      sd00039
      Location:25912627
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:25962775
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl22861
      Location:229376
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    3. NM_030695.2NP_109620.2  lipopolysaccharide-responsive and beige-like anchor protein isoform alpha

      Status: VALIDATED

      Source sequence(s)
      AC102270, AF187731, AF188507, AK031216, AK052148, BQ031803, CV556905
      Consensus CDS
      CCDS38470.1
      UniProtKB/Swiss-Prot
      Q9ESE1
      UniProtKB/TrEMBL
      E9Q3Y4, Q8BSM6, Q8C7C2
      Related
      ENSMUSP00000103261.2, ENSMUST00000107635.7
      Conserved Domains (9) summary
      COG2319
      Location:25812848
      WD40; WD40 repeat [General function prediction only]
      cd00020
      Location:672790
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam02138
      Location:22042480
      Beach; Beige/BEACH domain
      pfam06469
      Location:18822049
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:20752172
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:446717
      DUF4704; Domain of unknown function (DUF4704)
      sd00039
      Location:25912627
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:25962796
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl22861
      Location:229376
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      86130763..86690001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502347.4XP_006502410.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X1

      See identical proteins and their annotated locations for XP_006502410.1

      Conserved Domains (7) summary
      sd00039
      Location:26082644
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:22162492
      Beach; Beige/BEACH domain
      pfam06469
      Location:18822061
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:20872184
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:446717
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:229376
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:26132813
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006502349.4XP_006502412.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X2

      Conserved Domains (7) summary
      sd00039
      Location:26082644
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:22162492
      Beach; Beige/BEACH domain
      pfam06469
      Location:18822061
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:20872184
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:446717
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:229376
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:26132812
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_006502350.4XP_006502413.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X3

      Conserved Domains (7) summary
      sd00039
      Location:26032639
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:22162492
      Beach; Beige/BEACH domain
      pfam06469
      Location:18822061
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:20872184
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:446717
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:229376
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:26082808
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_006502351.4XP_006502414.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X4

      Conserved Domains (7) summary
      sd00039
      Location:25962632
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:22042480
      Beach; Beige/BEACH domain
      pfam06469
      Location:18822049
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:20752172
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:446717
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:229376
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:26012801
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_006502352.5XP_006502415.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X5

      Related
      ENSMUSP00000148618.2, ENSMUST00000212390.2
      Conserved Domains (4) summary
      pfam06469
      Location:18822061
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam15787
      Location:446717
      DUF4704; Domain of unknown function (DUF4704)
      cl17171
      Location:20802122
      PH-like; Pleckstrin homology-like domain
      cl22861
      Location:229376
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    6. XM_006502348.4XP_006502411.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X1

      See identical proteins and their annotated locations for XP_006502411.1

      Conserved Domains (7) summary
      sd00039
      Location:26082644
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:22162492
      Beach; Beige/BEACH domain
      pfam06469
      Location:18822061
      DUF1088; Domain of Unknown Function (DUF1088)
      pfam14844
      Location:20872184
      PH_BEACH; PH domain associated with Beige/BEACH
      pfam15787
      Location:446717
      DUF4704; Domain of unknown function (DUF4704)
      cl22861
      Location:229376
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl29593
      Location:26132813
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    7. XM_006502354.5XP_006502417.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X7

      Conserved Domains (4) summary
      sd00039
      Location:487523
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:95371
      Beach; Beige/BEACH domain
      cl17171
      Location:263
      PH-like; Pleckstrin homology-like domain
      cl29593
      Location:492692
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    8. XM_006502353.3XP_006502416.1  lipopolysaccharide-responsive and beige-like anchor protein isoform X6

      Related
      ENSMUSP00000141734.2, ENSMUST00000195524.2
      Conserved Domains (4) summary
      sd00039
      Location:515551
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:123399
      Beach; Beige/BEACH domain
      cl17171
      Location:1691
      PH-like; Pleckstrin homology-like domain
      cl29593
      Location:520720
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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