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    Hist1h1a histone cluster 1, H1a [ Mus musculus (house mouse) ]

    Gene ID: 80838, updated on 12-Aug-2018

    Summary

    Official Symbol
    Hist1h1aprovided by MGI
    Official Full Name
    histone cluster 1, H1aprovided by MGI
    Primary source
    MGI:MGI:1931523
    See related
    Ensembl:ENSMUSG00000049539 Vega:OTTMUSG00000000741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H1a; H1.1; H1f1; H1var3
    Summary
    Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]
    Orthologs

    Genomic context

    See Hist1h1a in Genome Data Viewer
    Location:
    13; 13 A3.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (23763668..23764412)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (23855537..23856283)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene histone cluster 1, H4a Neighboring gene histone cluster 1, H3a Neighboring gene tripartite motif-containing 38 Neighboring gene predicted gene 11337

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of chromatin silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    nucleosome positioning IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear euchromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H1.1
    Names
    H1 VAR.3
    H1 histone family, member 1
    histone 1, H1a
    histone H1a

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030609.3NP_085112.1  histone H1.1

      See identical proteins and their annotated locations for NP_085112.1

      Status: REVIEWED

      Source sequence(s)
      AL590388
      Consensus CDS
      CCDS26369.1
      UniProtKB/Swiss-Prot
      P43275
      Related
      ENSMUSP00000062030.1, OTTMUSP00000000668, ENSMUST00000055770.3, OTTMUST00000001395
      Conserved Domains (1) summary
      cd00073
      Location:40121
      H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      23763668..23764412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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