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    APOL4 apolipoprotein L4 [ Homo sapiens (human) ]

    Gene ID: 80832, updated on 23-Nov-2021

    Summary

    Official Symbol
    APOL4provided by HGNC
    Official Full Name
    apolipoprotein L4provided by HGNC
    Primary source
    HGNC:HGNC:14867
    See related
    Ensembl:ENSG00000100336 MIM:607254
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APOLIV; APOL-IV
    Summary
    This gene encodes a member of the apolipoprotein L family. The encoded protein may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2020]
    Expression
    Broad expression in prostate (RPKM 5.7), lung (RPKM 5.4) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See APOL4 in Genome Data Viewer
    Location:
    22q12.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (36189128..36204833, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36585176..36600879, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene MT-CYB pseudogene 34 Neighboring gene MT-ND1 pseudogene 10 Neighboring gene apolipoprotein L2 Neighboring gene apolipoprotein L1 Neighboring gene uncharacterized LOC112268296

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in lipid metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    apolipoprotein L4
    Names
    apolipoprotein L, 4
    apolipoprotein L-IV

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023437.1 RefSeqGene

      Range
      5001..20706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001386885.1NP_001373814.1  apolipoprotein L4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) differs in the 5' UTR, compared to variant a. Both variants a and d encode the same isoform (1).
      Source sequence(s)
      KF459718, Z95114
      Related
      ENSP00000507418.1, ENST00000683024.1
      Conserved Domains (1) summary
      pfam05461
      Location:43345
      ApoL; Apolipoprotein L
    2. NM_030643.4NP_085146.2  apolipoprotein L4 isoform 1

      See identical proteins and their annotated locations for NP_085146.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes isoform (1). Both variants a and d encode the same isoform.
      Source sequence(s)
      AW627682, AY014914, DA865632, Z95114
      Consensus CDS
      CCDS74851.1
      UniProtKB/Swiss-Prot
      Q9BPW4
      Related
      ENSP00000483497.1, ENST00000616056.4
      Conserved Domains (1) summary
      pfam05461
      Location:43345
      ApoL; Apolipoprotein L
    3. NM_145660.2NP_663693.1  apolipoprotein L4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_663693.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) lacks an internal exon in the 5' region, which results in upstream AUG start codon, compared to variant a. The resulting isoform (2) has a longer and distinct N-terminus, compared to isoform 1. Isoform 2 is thought to be a secreted protein.
      Source sequence(s)
      AW627682, AY014914, AY014915, DA865632, Z95114
      Consensus CDS
      CCDS74852.1
      UniProtKB/Swiss-Prot
      Q9BPW4
      Related
      ENSP00000338260.3, ENST00000352371.5
      Conserved Domains (1) summary
      pfam05461
      Location:60348
      ApoL; Apolipoprotein L
    4. NM_145661.2NP_663694.1  apolipoprotein L4 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) has multiple differences in the coding region compared to variant a, one of which results in a frameshift. The resulting isoform is shorter than isoform 1 and similar to it only at the N-terminus.
      Source sequence(s)
      Z95114
      Related
      ENSP00000380445.2, ENST00000397275.6

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      36189128..36204833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024452274.1XP_024308042.1  apolipoprotein L4 isoform X1

      Conserved Domains (1) summary
      pfam05461
      Location:1252
      ApoL; Apolipoprotein L
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