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    ACAD10 acyl-CoA dehydrogenase family member 10 [ Homo sapiens (human) ]

    Gene ID: 80724, updated on 2-Nov-2024

    Summary

    Official Symbol
    ACAD10provided by HGNC
    Official Full Name
    acyl-CoA dehydrogenase family member 10provided by HGNC
    Primary source
    HGNC:HGNC:21597
    See related
    Ensembl:ENSG00000111271 MIM:611181; AllianceGenome:HGNC:21597
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 11.6), duodenum (RPKM 7.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ACAD10 in Genome Data Viewer
    Location:
    12q24.12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (111686053..111757099)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (111662974..111734020)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112123857..112194903)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903020 Neighboring gene BRCA1 associated protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112122083-112122784 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112122785-112123486 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:112123487-112124188 Neighboring gene PEST containing nuclear protein pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112194124-112194765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112195407-112196048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112196049-112196688 Neighboring gene NANOG hESC enhancer GRCh37_chr12:112199468-112200003 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:112204196-112204965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112210937-112211508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7039 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112228790-112229715 Neighboring gene aldehyde dehydrogenase 2 family member Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:112229716-112230640 Neighboring gene microRNA 6761 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:112272338-112273217 Neighboring gene MAPKAPK5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7041 Neighboring gene MAPK activated protein kinase 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of a coronary artery disease risk variant.
    EBI GWAS Catalog
    A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
    EBI GWAS Catalog
    Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: ALDH2

    Clone Names

    • MGC5601

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acyl-CoA dehydrogenase activity TAS
    Traceable Author Statement
    more info
     
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
     
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    acyl-CoA dehydrogenase family member 10
    Names
    ACAD-10
    acyl-Coenzyme A dehydrogenase family, member 10
    NP_001130010.1
    NP_079523.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136538.2NP_001130010.1  acyl-CoA dehydrogenase family member 10 isoform a

      See identical proteins and their annotated locations for NP_001130010.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL832043, BC126358, CA419108, DA146693
      Consensus CDS
      CCDS44973.1
      UniProtKB/Swiss-Prot
      Q6JQN1
      Related
      ENSP00000389813.2, ENST00000455480.6
      Conserved Domains (5) summary
      PLN02876
      Location:2881087
      PLN02876; acyl-CoA dehydrogenase
      cd05154
      Location:317567
      ACAD10_11_N-like; N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins
      TIGR02247
      Location:41278
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase
      cl09933
      Location:6941087
      ACAD; Acyl-CoA dehydrogenase
      cl21460
      Location:46238
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    2. NM_025247.6NP_079523.3  acyl-CoA dehydrogenase family member 10 isoform b

      See identical proteins and their annotated locations for NP_079523.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AL832043, AY323912, CA419108, DA146693
      Consensus CDS
      CCDS31903.1
      UniProtKB/Swiss-Prot
      G3XAJ0, Q6JQN1, Q8N828, Q8NAP2, Q96BX5
      Related
      ENSP00000325137.5, ENST00000313698.9
      Conserved Domains (5) summary
      PLN02876
      Location:2571056
      PLN02876; acyl-CoA dehydrogenase
      cd05154
      Location:286536
      ACAD10_11_N-like; N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins
      TIGR02247
      Location:41247
      HAD-1A3-hyp; epoxide hydrolase N-terminal domain-like phosphatase
      cl09933
      Location:6631056
      ACAD; Acyl-CoA dehydrogenase
      cl21460
      Location:46236
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      111686053..111757099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      111662974..111734020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001136542.1: Suppressed sequence

      Description
      NM_001136542.1: This RefSeq was permanently suppressed because it is 3' partial and would be a nonsense-mediated mRNA decay (NMD) candidate if fully extended.