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    TSGA10 testis specific 10 [ Homo sapiens (human) ]

    Gene ID: 80705, updated on 17-Jun-2024

    Summary

    Official Symbol
    TSGA10provided by HGNC
    Official Full Name
    testis specific 10provided by HGNC
    Primary source
    HGNC:HGNC:14927
    See related
    Ensembl:ENSG00000135951 MIM:607166; AllianceGenome:HGNC:14927
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT79; CEP4L; SPGF26
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in spermatogenesis. Predicted to act upstream of or within cell projection assembly. Predicted to be located in neuron projection; sperm fibrous sheath; and sperm principal piece. Implicated in spermatogenic failure 26. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 16.6) and thyroid (RPKM 1.5) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TSGA10 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (98997261..99154966, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (99455791..99613837, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99613724..99771429, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U4 small nuclear 84, pseudogene Neighboring gene CRACD like Neighboring gene Sharpr-MPRA regulatory region 14605 Neighboring gene RNA, U7 small nuclear 46 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99485973-99486580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99526123-99526622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99529037-99529620 Neighboring gene Sharpr-MPRA regulatory region 6151 Neighboring gene MPRA-validated peak3796 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:99656987-99658186 Neighboring gene NANOG hESC enhancer GRCh37_chr2:99698262-99699020 Neighboring gene SMC3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:99758101-99758907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:99771037-99771658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16277 Neighboring gene chromosome 2 open reading frame 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16280 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:99797856-99798028 Neighboring gene lipoyltransferase 1 Neighboring gene microtubule interacting and trafficking domain containing 1 Neighboring gene mitochondrial ribosomal protein L30

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Spermatogenic failure 26
    MedGen: C4693773 OMIM: 617961 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in spermatogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    testis-specific gene 10 protein
    Names
    cancer/testis antigen 79
    testis development protein NYD-SP7
    testis-specific 10 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001349012.1NP_001335941.1  testis-specific gene 10 protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AC019097, AC092587, AC110083
      Consensus CDS
      CCDS2037.1
      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
      Related
      ENSP00000377122.3, ENST00000393482.7
      Conserved Domains (2) summary
      cl25732
      Location:140504
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26472
      Location:412615
      DUF3084; Protein of unknown function (DUF3084)
    2. NM_001349013.2NP_001335942.1  testis-specific gene 10 protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks three alternate in-frame exons in the 5' coding region compared to variant 1. Both variants 4 and 5 encode the same isoform (2).
      Source sequence(s)
      AC019097, AC092587, AC110083
      UniProtKB/TrEMBL
      B2R8F9
      Conserved Domains (2) summary
      cl25632
      Location:90280
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      cl25732
      Location:214490
      SMC_N; RecF/RecN/SMC N terminal domain
    3. NM_001349014.1NP_001335943.1  testis-specific gene 10 protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks three alternate in-frame exons in the 5' coding region compared to variant 1. Both variants 4 and 5 encode the same isoform (2).
      Source sequence(s)
      AC019097, AC092587
      UniProtKB/TrEMBL
      B2R8F9
      Conserved Domains (2) summary
      cl25632
      Location:90280
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      cl25732
      Location:214490
      SMC_N; RecF/RecN/SMC N terminal domain
    4. NM_025244.4NP_079520.1  testis-specific gene 10 protein isoform 1

      See identical proteins and their annotated locations for NP_079520.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AC019097, AC092587, AF254756, BX647157, DB085678, DC396566
      Consensus CDS
      CCDS2037.1
      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
      Related
      ENSP00000377123.3, ENST00000393483.8
      Conserved Domains (2) summary
      cl25732
      Location:140504
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26472
      Location:412615
      DUF3084; Protein of unknown function (DUF3084)
    5. NM_182911.4NP_878915.2  testis-specific gene 10 protein isoform 1

      See identical proteins and their annotated locations for NP_878915.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AC019097, AC092587, AF254756, BC028366, BI562202
      Consensus CDS
      CCDS2037.1
      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
      Related
      ENSP00000347161.4, ENST00000355053.8
      Conserved Domains (2) summary
      cl25732
      Location:140504
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26472
      Location:412615
      DUF3084; Protein of unknown function (DUF3084)

    RNA

    1. NR_146001.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate first exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC019097, AC092587, AC110083
    2. NR_146053.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has an alternate 5' and 3' exon structure compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
      Source sequence(s)
      AC092587, BE044403, BX490754
      Related
      ENST00000465216.1
    3. NR_146054.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) has an alternate 5' and 3' exon structure compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
      Source sequence(s)
      AC092587, BE044403
    4. NR_146055.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) has an alternate 5' and 3' exon structure compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
      Source sequence(s)
      AC092587, BE044403
      Related
      ENST00000489348.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      98997261..99154966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445934.1XP_047301890.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
    2. XM_047445931.1XP_047301887.1  testis-specific gene 10 protein isoform X3

      UniProtKB/TrEMBL
      A0A669KBL0
    3. XM_047445932.1XP_047301888.1  testis-specific gene 10 protein isoform X3

      UniProtKB/TrEMBL
      A0A669KBL0
    4. XM_017005041.3XP_016860530.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
      Conserved Domains (2) summary
      cl25732
      Location:140504
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26472
      Location:412615
      DUF3084; Protein of unknown function (DUF3084)
    5. XM_047445929.1XP_047301885.1  testis-specific gene 10 protein isoform X3

      UniProtKB/TrEMBL
      A0A669KBL0
    6. XM_047445930.1XP_047301886.1  testis-specific gene 10 protein isoform X3

      UniProtKB/TrEMBL
      A0A669KBL0
    7. XM_047445928.1XP_047301884.1  testis-specific gene 10 protein isoform X3

      UniProtKB/TrEMBL
      A0A669KBL0
    8. XM_047445933.1XP_047301889.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
    9. XM_005264023.2XP_005264080.1  testis-specific gene 10 protein isoform X6

      See identical proteins and their annotated locations for XP_005264080.1

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
      Related
      ENSP00000386508.2, ENST00000409564.6
      Conserved Domains (2) summary
      cl25732
      Location:140504
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26472
      Location:412615
      DUF3084; Protein of unknown function (DUF3084)
    10. XM_017005035.2XP_016860524.1  testis-specific gene 10 protein isoform X2

      UniProtKB/TrEMBL
      A0A669KBL0
    11. XM_011511935.4XP_011510237.1  testis-specific gene 10 protein isoform X4

      UniProtKB/TrEMBL
      B2R8F9
      Conserved Domains (3) summary
      COG1196
      Location:268632
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4372
      Location:540743
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:70399
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    12. XM_011511934.1XP_011510236.1  testis-specific gene 10 protein isoform X1

      UniProtKB/TrEMBL
      A0A669KBL0
      Related
      ENSP00000501312.1, ENST00000674128.1
      Conserved Domains (1) summary
      pfam05377
      Location:5096
      FlaC_arch; Flagella accessory protein C (FlaC)
    13. XM_017005044.2XP_016860533.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
      Conserved Domains (2) summary
      cl25732
      Location:140504
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26472
      Location:412615
      DUF3084; Protein of unknown function (DUF3084)
    14. XM_024453158.2XP_024308926.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
      Related
      ENSP00000386956.1, ENST00000410001.5
      Conserved Domains (2) summary
      cl25732
      Location:140504
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26472
      Location:412615
      DUF3084; Protein of unknown function (DUF3084)
    15. XM_006712781.3XP_006712844.1  testis-specific gene 10 protein isoform X6

      See identical proteins and their annotated locations for XP_006712844.1

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
      Conserved Domains (2) summary
      cl25732
      Location:140504
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26472
      Location:412615
      DUF3084; Protein of unknown function (DUF3084)
    16. XM_017005046.2XP_016860535.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
      Conserved Domains (2) summary
      cl25732
      Location:140504
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26472
      Location:412615
      DUF3084; Protein of unknown function (DUF3084)
    17. XM_017005037.1XP_016860526.1  testis-specific gene 10 protein isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      99455791..99613837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344073.1XP_054200048.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
    2. XM_054344063.1XP_054200038.1  testis-specific gene 10 protein isoform X3

      UniProtKB/TrEMBL
      A0A669KBL0
    3. XM_054344064.1XP_054200039.1  testis-specific gene 10 protein isoform X3

      UniProtKB/TrEMBL
      A0A669KBL0
    4. XM_054344068.1XP_054200043.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
    5. XM_054344061.1XP_054200036.1  testis-specific gene 10 protein isoform X3

      UniProtKB/TrEMBL
      A0A669KBL0
    6. XM_054344062.1XP_054200037.1  testis-specific gene 10 protein isoform X3

      UniProtKB/TrEMBL
      A0A669KBL0
    7. XM_054344069.1XP_054200044.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
    8. XM_054344067.1XP_054200042.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
    9. XM_054344065.1XP_054200040.1  testis-specific gene 10 protein isoform X4

      UniProtKB/TrEMBL
      B2R8F9
    10. XM_054344059.1XP_054200034.1  testis-specific gene 10 protein isoform X1

      UniProtKB/TrEMBL
      A0A669KBL0
    11. XM_054344060.1XP_054200035.1  testis-specific gene 10 protein isoform X2

      UniProtKB/TrEMBL
      A0A669KBL0
    12. XM_054344070.1XP_054200045.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
    13. XM_054344071.1XP_054200046.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
    14. XM_054344072.1XP_054200047.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
    15. XM_054344074.1XP_054200049.1  testis-specific gene 10 protein isoform X6

      UniProtKB/Swiss-Prot
      B7Z925, D3DVH7, Q8NEP0, Q9BWX0, Q9BZW7
      UniProtKB/TrEMBL
      A0A218MIY9, B2R8F9
    16. XM_054344066.1XP_054200041.1  testis-specific gene 10 protein isoform X5