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    Herpud2 HERPUD family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 80517, updated on 12-May-2024


    Official Symbol
    Herpud2provided by MGI
    Official Full Name
    HERPUD family member 2provided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000008429 AllianceGenome:MGI:1915393
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acts upstream of or within spermatogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system gland; nervous system; and reproductive system. Orthologous to human HERPUD2 (HERPUD family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Ubiquitous expression in testis adult (RPKM 53.4), adrenal adult (RPKM 48.5) and 28 other tissues See more
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    Genomic context

    See Herpud2 in Genome Data Viewer
    9 A4; 9 10.25 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (25012412..25063109, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (25108126..25151813, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130101E03 gene Neighboring gene transmembrane protein 126B pseudogene Neighboring gene STARR-seq mESC enhancer starr_23595 Neighboring gene STARR-seq mESC enhancer starr_23596 Neighboring gene predicted gene 29642 Neighboring gene STARR-seq mESC enhancer starr_23597 Neighboring gene RIKEN cDNA 9130004C02 gene Neighboring gene high mobility group box 2 pseudogene Neighboring gene septin 7

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Spontaneous (1)  1 citation
    • Targeted (2) 

    General gene information


    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    acts_upstream_of_or_within response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info

    General protein information

    Preferred Names
    homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020586.2NP_065611.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

      See identical proteins and their annotated locations for NP_065611.1

      Status: VALIDATED

      Source sequence(s)
      AC113082, CT025561
      Consensus CDS
      Q8K2W2, Q9CSZ4, Q9D2D0, Q9JJC9
      ENSMUSP00000008573.8, ENSMUST00000008573.9
      Conserved Domains (2) summary
      Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
      UBQ; Ubiquitin homologues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000075.7 Reference GRCm39 C57BL/6J

      25012412..25063109 complement
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510706.4XP_006510769.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein isoform X1

      Conserved Domains (1) summary
      Ubl_HERP2; ubiquitin-like (Ubl) domain found in homocysteine-inducible endoplasmic reticulum stress protein HERP2 and similar proteins