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    ULBP2 UL16 binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 80328, updated on 17-Jun-2024

    Summary

    Official Symbol
    ULBP2provided by HGNC
    Official Full Name
    UL16 binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:14894
    See related
    Ensembl:ENSG00000131015 MIM:605698; AllianceGenome:HGNC:14894
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    N2DL2; RAET1H; RAET1L; NKG2DL2; ALCAN-alpha
    Summary
    This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]
    Expression
    Biased expression in esophagus (RPKM 5.0), lung (RPKM 1.3) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ULBP2 in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149942014..149949235)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (151141356..151148578)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150263150..150270371)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RAET1E antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:150238439-150238724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150246453-150246988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150246989-150247523 Neighboring gene retinoic acid early transcript 1G Neighboring gene uncharacterized LOC105378052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:150259106-150259796 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:150259797-150260487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150274681-150275653 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150275654-150276625 Neighboring gene Sharpr-MPRA regulatory region 14768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150285415-150285954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150286496-150287035 Neighboring gene UL16 binding protein 1 Neighboring gene basic transcription factor 3 pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 (SF2) Nef downregulates ULBP2; downregulation is dependent upon residues G2 and F195 and a di-lysine motif in Nef as shown in A3.01 T cells and HeLa TZM-bl cells PubMed
    nef HIV-1 Nef downregulates cell surface expression of MICA, ULBP1 and ULBP2 in natural killer (NK) cells PubMed
    Vif vif HIV-1 Vif expression in HIV-1 infected cells results in less HIV-1 Vpr-dependent upregulation of NKG2D ligands PubMed
    vif A3G upregulates NKG2D ligands through an ATM pathway and in which HIV-1 Vif counteracts this upregulation by decreasing A3G expression PubMed
    vif Vpr-dependent induction and Vif-mediated attenuation of NKG2D ligands are required for Chk2 phosphorylation in HIV infection PubMed
    Vpr vpr HIV-1 Vpr from most HIV-1 primary isolates can upregulate ULBP2 expression and induce NKG2D-dependent NK cell killing PubMed
    vpr Soluble HIV-1 Vpr promotes cell cycle arrest and upregulates cell-surface expression of ULBP2 in T cells PubMed
    vpr HIV-1 Vpr upregulates NKG2D ligands via the ATR pathway PubMed
    vpr HIV-1-Vpr induced upregulation of NKG2D ligands in HIV-infected T cells by activating UNG2-dependent repair of uridine-containing DNA PubMed
    vpr Vpr-dependent induction and Vif-mediated attenuation of NKG2D ligands are required for Chk2 phosphorylation in HIV infection PubMed
    vpr HIV-1 Vif expression in HIV-1 infected cells results in less HIV-1 Vpr-dependent upregulation of NKG2D ligands PubMed
    vpr Upregulation of NKG2D ligands is dependent on HIV-1 Vpr-mediated activation of the TAR DNA damage/stress pathway, which requires the recruitment of the Cul4/DDB1/DCAF1 E3 ubiquitin ligase complex PubMed
    Vpu vpu HIV-1 (NL4-3) Vpu downregulates ULBP2; downregulation is dependent upon amino acids R30/K31, V25/Y29, the acidic di-leucine motif in Vpu helix 2 as shown in A3.01 T cells and HeLa TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables natural killer cell lectin-like receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    UL16-binding protein 2
    Names
    NKG2D ligand 2
    retinoic acid early transcript 1H
    retinoic acid early transcript 1L

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025217.4NP_079493.1  UL16-binding protein 2 preproprotein

      See identical proteins and their annotated locations for NP_079493.1

      Status: REVIEWED

      Source sequence(s)
      AL583835, AY358665, BG718474
      Consensus CDS
      CCDS5222.1
      UniProtKB/Swiss-Prot
      Q5VUN4, Q9BZM5
      UniProtKB/TrEMBL
      Q8IZX9
      Related
      ENSP00000356320.3, ENST00000367351.4
      Conserved Domains (1) summary
      cl08246
      Location:30198
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      149942014..149949235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011321.2XP_016866810.1  UL16-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      B4DSS7
      Conserved Domains (1) summary
      cl08246
      Location:30198
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    2. XM_047419377.1XP_047275333.1  UL16-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5VUN4, Q9BZM5
      UniProtKB/TrEMBL
      Q8IZX9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      151141356..151148578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356467.1XP_054212442.1  UL16-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      B4DSS7
    2. XM_054356466.1XP_054212441.1  UL16-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5VUN4, Q9BZM5
      UniProtKB/TrEMBL
      Q8IZX9