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    Tusc3 tumor suppressor candidate 3 [ Mus musculus (house mouse) ]

    Gene ID: 80286, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tusc3provided by MGI
    Official Full Name
    tumor suppressor candidate 3provided by MGI
    Primary source
    MGI:MGI:1933134
    See related
    Ensembl:ENSMUSG00000118664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N33; AU022242; BC003311
    Expression
    Ubiquitous expression in CNS E18 (RPKM 43.6), whole brain E14.5 (RPKM 27.6) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Tusc3 in Genome Data Viewer
    Location:
    8; 8 A4
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (39472505..39620091)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (39005351..39167050)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (40068921..40193932) , (40242614..40250468)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene sarcoglycan zeta Neighboring gene predicted gene, 40493 Neighboring gene predicted gene, 23128 Neighboring gene MAD homolog 2 pseudogene Neighboring gene ribosomal protein L10A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6989

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in magnesium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tumor suppressor candidate 3
    Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3
    magnesium uptake/transporter TUSC3
    oligosaccharyl transferase subunit TUSC3
    putative prostate cancer tumor suppressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357304.1NP_001344233.1  tumor suppressor candidate 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC168314, AC174643
      Conserved Domains (1) summary
      pfam04756
      Location:45215
      OST3_OST6; OST3 / OST6 family, transporter family
    2. NM_001357305.1NP_001344234.1  tumor suppressor candidate 3 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC168314, AC174643
      Conserved Domains (1) summary
      pfam04756
      Location:54312
      OST3_OST6; OST3 / OST6 family, transporter family
    3. NM_001357306.1NP_001344235.1  tumor suppressor candidate 3 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC168314, AC174643
      Related
      ENSMUSP00000159387.2, ENSMUST00000239509.1
      Conserved Domains (1) summary
      pfam04756
      Location:54342
      OST3_OST6; OST3 / OST6 family, transporter family
    4. NM_030254.4NP_084530.3  tumor suppressor candidate 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_084530.3

      Status: VALIDATED

      Source sequence(s)
      AK081223, AK132766, BC069898, BP765707
      Consensus CDS
      CCDS85529.1
      UniProtKB/Swiss-Prot
      Q8BTV1
      Related
      ENSMUSP00000159386.2, ENSMUST00000239508.1
      Conserved Domains (1) summary
      pfam04756
      Location:54342
      OST3_OST6; OST3 / OST6 family, transporter family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      39472505..39620091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313026.3XP_017168515.1  tumor suppressor candidate 3 isoform X2

      Conserved Domains (1) summary
      pfam04756
      Location:54295
      OST3_OST6; OST3 / OST6 family, transporter family
    2. XM_017313027.3XP_017168516.1  tumor suppressor candidate 3 isoform X3

      Conserved Domains (1) summary
      pfam04756
      Location:54295
      OST3_OST6; OST3 / OST6 family, transporter family
    3. XM_017313024.3XP_017168513.1  tumor suppressor candidate 3 isoform X1

      Conserved Domains (1) summary
      pfam04756
      Location:54312
      OST3_OST6; OST3 / OST6 family, transporter family
    4. XM_036154388.1XP_036010281.1  tumor suppressor candidate 3 isoform X5

      Conserved Domains (1) summary
      pfam04756
      Location:1286
      OST3_OST6; OST3 / OST6 family, transporter family
    5. XM_017313028.2XP_017168517.1  tumor suppressor candidate 3 isoform X4

      Conserved Domains (1) summary
      pfam04756
      Location:4286
      OST3_OST6; OST3 / OST6 family, transporter family
    6. XM_036154387.1XP_036010280.1  tumor suppressor candidate 3 isoform X5

      Conserved Domains (1) summary
      pfam04756
      Location:1286
      OST3_OST6; OST3 / OST6 family, transporter family
    7. XM_017313029.2XP_017168518.1  tumor suppressor candidate 3 isoform X4

      Conserved Domains (1) summary
      pfam04756
      Location:4286
      OST3_OST6; OST3 / OST6 family, transporter family

    RNA

    1. XR_004934902.1 RNA Sequence

    2. XR_004934901.1 RNA Sequence

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