U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ZNF430 zinc finger protein 430 [ Homo sapiens (human) ]

    Gene ID: 80264, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF430provided by HGNC
    Official Full Name
    zinc finger protein 430provided by HGNC
    Primary source
    HGNC:HGNC:20808
    See related
    Ensembl:ENSG00000118620 AllianceGenome:HGNC:20808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in substantia nigra development. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 6.0), thyroid (RPKM 5.3) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF430 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (21020657..21060050)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (21159242..21198699)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21203463..21242856)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 40 Neighboring gene uncharacterized LOC112268247 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21183049-21183582 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:21203153-21203746 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:21203747-21204338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:21206984-21207484 Neighboring gene vomeronasal 1 receptor 80 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14381 Neighboring gene zinc finger protein 714 Neighboring gene RNA, 5S ribosomal pseudogene 469

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 430 (ZNF430) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13659, MGC133232, DKFZp762K012

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172671.2NP_001166142.1  zinc finger protein 430 isoform 2

      See identical proteins and their annotated locations for NP_001166142.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) lacks one internal amino acid, compared to isoform 1.
      Source sequence(s)
      AC012627, AK290475, BC111776, DB255551
      UniProtKB/TrEMBL
      Q2NKJ9
      Conserved Domains (5) summary
      smart00349
      Location:3595
      KRAB; krueppel associated box
      COG5048
      Location:201561
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:3574
      KRAB; KRAB box
      pfam13465
      Location:247271
      zf-H2C2_2; Zinc-finger double domain
    2. NM_025189.4NP_079465.3  zinc finger protein 430 isoform 1

      See identical proteins and their annotated locations for NP_079465.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC012627, AK290475, DB255551
      Consensus CDS
      CCDS32978.1
      UniProtKB/Swiss-Prot
      Q86V70, Q9H8G1
      Related
      ENSP00000261560.4, ENST00000261560.10
      Conserved Domains (5) summary
      smart00349
      Location:3596
      KRAB; krueppel associated box
      COG5048
      Location:202562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:3574
      KRAB; KRAB box
      pfam13465
      Location:248272
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      21020657..21060050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439464.1XP_047295420.1  zinc finger protein 430 isoform X1

    2. XM_047439465.1XP_047295421.1  zinc finger protein 430 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315962.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      363933..377460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      21159242..21198699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322229.1XP_054178204.1  zinc finger protein 430 isoform X1

    2. XM_054322230.1XP_054178205.1  zinc finger protein 430 isoform X2