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    ASRGL1 asparaginase and isoaspartyl peptidase 1 [ Homo sapiens (human) ]

    Gene ID: 80150, updated on 8-Dec-2022

    Summary

    Official Symbol
    ASRGL1provided by HGNC
    Official Full Name
    asparaginase and isoaspartyl peptidase 1provided by HGNC
    Primary source
    HGNC:HGNC:16448
    See related
    Ensembl:ENSG00000162174 MIM:609212; AllianceGenome:HGNC:16448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALP; ALP1; CRASH
    Summary
    Enables asparaginase activity and beta-aspartyl-peptidase activity. Involved in asparagine catabolic process via L-aspartate. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 38.7), kidney (RPKM 13.5) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ASRGL1 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62337448..62401431)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62326729..62382841)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62104920..62160884)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene secretoglobin family 1D member 4 Neighboring gene nucleophosmin 1 pseudogene 35 Neighboring gene uncharacterized LOC124902682 Neighboring gene regulator of chromosome condensation 2 pseudogene 6 Neighboring gene uncharacterized LOC102723765 Neighboring gene secretoglobin family 1A member 1 Neighboring gene AHNAK nucleoprotein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of asparaginase like 1 (ASRGL1) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ22316

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in asparagine catabolic process via L-aspartate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in asparagine catabolic process via L-aspartate ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autoprocessing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    located_in photoreceptor inner segment ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    isoaspartyl peptidase/L-asparaginase
    Names
    L-asparaginase
    L-asparagine amidohydrolase
    asparaginase like 1
    asparaginase-like 1 protein
    asparaginase-like protein 1
    beta-aspartyl-peptidase
    isoaspartyl dipeptidase
    testis secretory sperm-binding protein Li 242mP
    NP_001077395.1
    NP_079356.3
    XP_011543567.1
    XP_011543568.1
    XP_047283587.1
    XP_047283588.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083926.2NP_001077395.1  isoaspartyl peptidase/L-asparaginase

      See identical proteins and their annotated locations for NP_001077395.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AP003064, BC093070, DA159051, DT220454
      Consensus CDS
      CCDS8019.1
      UniProtKB/Swiss-Prot
      Q7L266, Q9H6F7
      UniProtKB/TrEMBL
      A0A024R573
      Related
      ENSP00000400057.2, ENST00000415229.6
      Conserved Domains (2) summary
      PRK10226
      Location:1290
      PRK10226; isoaspartyl peptidase; Provisional
      cd04702
      Location:2291
      ASRGL1_like; Metazoan L-Asparaginase type 2
    2. NM_025080.4NP_079356.3  isoaspartyl peptidase/L-asparaginase

      See identical proteins and their annotated locations for NP_079356.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AP003064, BC021295, BP308677, DT220454
      Consensus CDS
      CCDS8019.1
      UniProtKB/Swiss-Prot
      Q7L266, Q9H6F7
      UniProtKB/TrEMBL
      A0A024R573
      Related
      ENSP00000301776.5, ENST00000301776.9
      Conserved Domains (2) summary
      PRK10226
      Location:1290
      PRK10226; isoaspartyl peptidase; Provisional
      cd04702
      Location:2291
      ASRGL1_like; Metazoan L-Asparaginase type 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      62337448..62401431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545265.4XP_011543567.1  isoaspartyl peptidase/L-asparaginase isoform X1

      Conserved Domains (1) summary
      cd04702
      Location:2203
      ASRGL1_like; Metazoan L-Asparaginase type 2
    2. XM_047427631.1XP_047283587.1  isoaspartyl peptidase/L-asparaginase isoform X2

    3. XM_047427632.1XP_047283588.1  isoaspartyl peptidase/L-asparaginase isoform X3

    4. XM_011545266.4XP_011543568.1  isoaspartyl peptidase/L-asparaginase isoform X3

      Related
      ENSP00000478649.1, ENST00000534571.5
      Conserved Domains (1) summary
      cl00635
      Location:2183
      Ntn_Asparaginase_2_like; L-Asparaginase type 2-like enzymes of the NTN-hydrolase superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      62326729..62382841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)