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    MZT2B mitotic spindle organizing protein 2B [ Homo sapiens (human) ]

    Gene ID: 80097, updated on 5-May-2024

    Summary

    Official Symbol
    MZT2Bprovided by HGNC
    Official Full Name
    mitotic spindle organizing protein 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:25886
    See related
    Ensembl:ENSG00000152082 MIM:613450; AllianceGenome:HGNC:25886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM128B; MOZART2B
    Summary
    Located in cytosol; microtubule cytoskeleton; and nucleoplasm. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in fat (RPKM 10.8), colon (RPKM 10.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    2q21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (130181654..130204793)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (130616158..130638685)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (130939835..130948300)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene POTE ankyrin domain family member F Neighboring gene RNA, U6 small nuclear 1049, pseudogene Neighboring gene POTEF antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:130886707-130887281 Neighboring gene mediator complex subunit 15 pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16521 Neighboring gene coiled-coil domain containing 74B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:130917957-130918586 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:130921824-130922007 Neighboring gene sphingomyelin phosphodiesterase 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:130938087-130938883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:130940784-130941520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:130941521-130942257 Neighboring gene tubulin alpha 3e Neighboring gene ras homolog family member Q pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16524 Neighboring gene NOC2 like nucleolar associated transcriptional repressor pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14346, MGC87017

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of gamma-tubulin ring complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitotic-spindle organizing protein 2B
    Names
    family with sequence similarity 128, member B
    mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330282.2NP_001317211.1  mitotic-spindle organizing protein 2B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC018804
      Consensus CDS
      CCDS82511.1
      UniProtKB/TrEMBL
      B8ZZ87
      Related
      ENSP00000386419.1, ENST00000409255.1
      Conserved Domains (1) summary
      pfam12926
      Location:996
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated
    2. NM_001330284.2NP_001317213.1  mitotic-spindle organizing protein 2B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC018804
      UniProtKB/TrEMBL
      H7C293
      Related
      ENSP00000404629.1, ENST00000455239.1
      Conserved Domains (1) summary
      pfam12926
      Location:957
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated
    3. NM_025029.5NP_079305.2  mitotic-spindle organizing protein 2B isoform 2

      See identical proteins and their annotated locations for NP_079305.2

      Status: VALIDATED

      Source sequence(s)
      AC018804, BC014255
      Consensus CDS
      CCDS2157.1
      UniProtKB/Swiss-Prot
      Q6NZ67, Q96CG4
      UniProtKB/TrEMBL
      A0A494C0V9
      Related
      ENSP00000281871.7, ENST00000281871.11
      Conserved Domains (1) summary
      pfam12926
      Location:996
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      130181654..130204793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445915.1XP_047301871.1  mitotic-spindle organizing protein 2B isoform X2

    2. XM_047445914.1XP_047301870.1  mitotic-spindle organizing protein 2B isoform X1

    3. XM_047445916.1XP_047301872.1  mitotic-spindle organizing protein 2B isoform X3

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791762.1 Reference GRCh38.p14 PATCHES

      Range
      358261..381343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332887.1XP_054188862.1  mitotic-spindle organizing protein 2B isoform X2

    2. XM_054332886.1XP_054188861.1  mitotic-spindle organizing protein 2B isoform X1

    3. XM_054332888.1XP_054188863.1  mitotic-spindle organizing protein 2B isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      130616158..130638685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344025.1XP_054200000.1  mitotic-spindle organizing protein 2B isoform X1

    2. XM_054344026.1XP_054200001.1  mitotic-spindle organizing protein 2B isoform X3