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    ATF7IP2 activating transcription factor 7 interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 80063, updated on 25-Nov-2021

    Summary

    Official Symbol
    ATF7IP2provided by HGNC
    Official Full Name
    activating transcription factor 7 interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:20397
    See related
    Ensembl:ENSG00000166669 MIM:613645
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCAF2
    Expression
    Broad expression in testis (RPKM 6.9), lymph node (RPKM 2.0) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ATF7IP2 in Genome Data Viewer
    Location:
    16p13.2-p13.13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (10386061..10483643)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (10479918..10577495)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371078 Neighboring gene VISTA enhancer hs1242 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1137 Neighboring gene uncharacterized LOC107984877 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1145 Neighboring gene RNA, U6 small nuclear 633, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    Associated conditions

    Description Tests
    Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12668

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA methylation-dependent heterochromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    activating transcription factor 7-interacting protein 2
    Names
    ATF7-interacting protein 2
    MBD1-containing chromatin associated factor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256160.3NP_001243089.1  activating transcription factor 7-interacting protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001243089.1

      Status: VALIDATED

      Source sequence(s)
      AC131649, AK093414, AL832987, BC144468
      Consensus CDS
      CCDS58422.1
      UniProtKB/Swiss-Prot
      Q5U623
      Related
      ENSP00000379807.1, ENST00000396559.5
      Conserved Domains (1) summary
      pfam16788
      Location:291496
      ATF7IP_BD; ATF-interacting protein binding domain
    2. NM_001352120.2NP_001339049.1  activating transcription factor 7-interacting protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131649
      Consensus CDS
      CCDS10540.1
      Conserved Domains (2) summary
      pfam16788
      Location:292496
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:574673
      fn3_4; Fibronectin-III type domain
    3. NM_001393719.1NP_001380648.1  activating transcription factor 7-interacting protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131649
      Conserved Domains (2) summary
      pfam16788
      Location:292496
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:574673
      fn3_4; Fibronectin-III type domain
    4. NM_024997.5NP_079273.2  activating transcription factor 7-interacting protein 2 isoform 1

      See identical proteins and their annotated locations for NP_079273.2

      Status: VALIDATED

      Source sequence(s)
      AC131649, AL832987, BC033891, BC137079
      Consensus CDS
      CCDS10540.1
      UniProtKB/Swiss-Prot
      Q5U623
      Related
      ENSP00000379808.2, ENST00000396560.6
      Conserved Domains (2) summary
      pfam16788
      Location:292496
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:574673
      fn3_4; Fibronectin-III type domain

    RNA

    1. NR_045815.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131649
      Related
      ENST00000568027.5
    2. NR_045816.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131649, AK299040, AL832987, BC144468
    3. NR_147927.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131649

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      10386061..10483643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023706.2XP_016879195.1  activating transcription factor 7-interacting protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q5U623
      Conserved Domains (1) summary
      pfam16788
      Location:291496
      ATF7IP_BD; ATF-interacting protein binding domain
    2. XM_017023705.2XP_016879194.1  activating transcription factor 7-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5U623
      Conserved Domains (2) summary
      pfam16788
      Location:292496
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:574673
      fn3_4; Fibronectin-III type domain
    3. XM_017023707.2XP_016879196.1  activating transcription factor 7-interacting protein 2 isoform X3

      Related
      ENSP00000440791.1, ENST00000535850.5
    4. XM_006720954.4XP_006721017.1  activating transcription factor 7-interacting protein 2 isoform X5

      Conserved Domains (1) summary
      pfam16788
      Location:291366
      ATF7IP_BD; ATF-interacting protein binding domain
    5. XM_006720953.3XP_006721016.1  activating transcription factor 7-interacting protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006721016.1

      UniProtKB/Swiss-Prot
      Q5U623
      Related
      ENSP00000348799.2, ENST00000356427.2
      Conserved Domains (2) summary
      pfam16788
      Location:292496
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:574673
      fn3_4; Fibronectin-III type domain
    6. XM_017023710.1XP_016879199.1  activating transcription factor 7-interacting protein 2 isoform X7

    7. XM_017023708.1XP_016879197.1  activating transcription factor 7-interacting protein 2 isoform X4

    8. XM_017023711.1XP_016879200.1  activating transcription factor 7-interacting protein 2 isoform X8

      Related
      ENSP00000446119.1, ENST00000543967.5
    9. XM_011522666.2XP_011520968.1  activating transcription factor 7-interacting protein 2 isoform X6

      Conserved Domains (2) summary
      pfam16788
      Location:7108
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:186285
      fn3_4; Fibronectin-III type domain
    10. XM_017023709.1XP_016879198.1  activating transcription factor 7-interacting protein 2 isoform X6

      Conserved Domains (2) summary
      pfam16788
      Location:7108
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:186285
      fn3_4; Fibronectin-III type domain

    RNA

    1. XR_001751990.1 RNA Sequence

    2. XR_001751992.2 RNA Sequence

    3. XR_001751991.1 RNA Sequence

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