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    DOCK5 dedicator of cytokinesis 5 [ Homo sapiens (human) ]

    Gene ID: 80005, updated on 3-Nov-2024

    Summary

    Official Symbol
    DOCK5provided by HGNC
    Official Full Name
    dedicator of cytokinesis 5provided by HGNC
    Primary source
    HGNC:HGNC:23476
    See related
    Ensembl:ENSG00000147459 MIM:616904; AllianceGenome:HGNC:23476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]
    Expression
    Ubiquitous expression in spleen (RPKM 6.2), small intestine (RPKM 5.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DOCK5 in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (25184689..25415711)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (25463647..25690937)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (25042204..25273227)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ependymin related 1 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr8:25032605-25032808 Neighboring gene uncharacterized LOC124901912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19033 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:25054518-25055458 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:25055459-25056397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19034 Neighboring gene MPRA-validated peak6954 silencer Neighboring gene oocyte-secreted protein 4B-like Neighboring gene Sharpr-MPRA regulatory region 2993 Neighboring gene Sharpr-MPRA regulatory region 10341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27123 Neighboring gene Sharpr-MPRA regulatory region 6380 Neighboring gene uncharacterized LOC105379331 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:25217237-25217846 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:25217847-25218454 Neighboring gene microRNA 6876 Neighboring gene Sharpr-MPRA regulatory region 10380 Neighboring gene uncharacterized LOC124901913 Neighboring gene gonadotropin releasing hormone 1 Neighboring gene potassium channel tetramerization domain containing 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp451J181, DKFZp779M164, DKFZp781J211

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dedicator of cytokinesis protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051765.1 RefSeqGene

      Range
      4918..235940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322810.2NP_001309739.1  dedicator of cytokinesis protein 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC041005, AC091185, BC015352
      Consensus CDS
      CCDS83265.1
      UniProtKB/TrEMBL
      B9A015
      Related
      ENSP00000387036.1, ENST00000410074.5
    2. NM_024940.8NP_079216.4  dedicator of cytokinesis protein 5 isoform 1

      See identical proteins and their annotated locations for NP_079216.4

      Status: REVIEWED

      Source sequence(s)
      AC041005, AC091185, AK024687, AK026663, AK126249, BC011877, BC015352, BC041761, BE549612, BF195734, BF884637, BX648352, CR627414, CR749353
      Consensus CDS
      CCDS6047.1
      UniProtKB/Swiss-Prot
      B2RNY0, Q5XKD5, Q6AI11, Q6PJS6, Q6ZTS6, Q9H7D0
      UniProtKB/TrEMBL
      A0A2X0SFZ7
      Related
      ENSP00000276440.7, ENST00000276440.12
      Conserved Domains (4) summary
      cd11708
      Location:12381637
      DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5
      cd12051
      Location:1267
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:75434
      DOCK_N; DOCK N-terminus
      cl14603
      Location:442637
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      25184689..25415711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      25463647..25690937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)