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    ZNF442 zinc finger protein 442 [ Homo sapiens (human) ]

    Gene ID: 79973, updated on 5-Mar-2024

    Summary

    Official Symbol
    ZNF442provided by HGNC
    Official Full Name
    zinc finger protein 442provided by HGNC
    Primary source
    HGNC:HGNC:20877
    See related
    Ensembl:ENSG00000198342 AllianceGenome:HGNC:20877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 1.4), thyroid (RPKM 0.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See ZNF442 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12345944..12373779, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12474291..12502125, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12456758..12476497, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 44 Neighboring gene ribosomal protein L28 pseudogene 5 Neighboring gene MPRA-validated peak3363 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14048 Neighboring gene ribosomal protein S2 pseudogene 53 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12444503-12445368 Neighboring gene zinc finger protein 563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14052 Neighboring gene ribosomal protein S29 pseudogene 23 Neighboring gene NANOG hESC enhancer GRCh37_chr19:12501177-12501678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14054 Neighboring gene zinc finger protein 799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10150 Neighboring gene zinc finger protein 443

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ14356

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363774.2NP_001350703.1  zinc finger protein 442 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008758, AK295923, DA151257, DC395131
      Consensus CDS
      CCDS86707.1
      Related
      ENSP00000388634.1, ENST00000438182.5
      Conserved Domains (2) summary
      COG5048
      Location:166553
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:449469
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_030824.3NP_110451.1  zinc finger protein 442 isoform 1

      See identical proteins and their annotated locations for NP_110451.1

      Status: VALIDATED

      Source sequence(s)
      AC008758, AK024418, DA151257
      Consensus CDS
      CCDS12271.1
      UniProtKB/Swiss-Prot
      B4DJ48, Q9H7R0
      Related
      ENSP00000242804.4, ENST00000242804.9
      Conserved Domains (5) summary
      smart00349
      Location:2969
      KRAB; krueppel associated box
      COG5048
      Location:160563
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2965
      KRAB; KRAB box
      pfam13465
      Location:307332
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      12345944..12373779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027317.2XP_016882806.1  zinc finger protein 442 isoform X1

    2. XM_006722908.4XP_006722971.1  zinc finger protein 442 isoform X2

      See identical proteins and their annotated locations for XP_006722971.1

      Conserved Domains (5) summary
      smart00349
      Location:2262
      KRAB; krueppel associated box
      COG5048
      Location:153556
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:511531
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2258
      KRAB; KRAB box
      pfam13465
      Location:300325
      zf-H2C2_2; Zinc-finger double domain
    3. XM_017027316.2XP_016882805.2  zinc finger protein 442 isoform X1

    RNA

    1. XR_007067014.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      12474291..12502125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322216.1XP_054178191.1  zinc finger protein 442 isoform X1

    2. XM_054322215.1XP_054178190.1  zinc finger protein 442 isoform X2

    3. XM_054322214.1XP_054178189.1  zinc finger protein 442 isoform X1

    RNA

    1. XR_008485203.1 RNA Sequence