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    LPCAT1 lysophosphatidylcholine acyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 79888, updated on 3-Dec-2024

    Summary

    Official Symbol
    LPCAT1provided by HGNC
    Official Full Name
    lysophosphatidylcholine acyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:25718
    See related
    Ensembl:ENSG00000153395 MIM:610472; AllianceGenome:HGNC:25718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AYTL2; lpcat; AGPAT9; LPLAT8; PFAAP3; AGPAT10; LPCAT-1; lysoPAFAT
    Summary
    This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016]
    Expression
    Broad expression in lung (RPKM 73.0), spleen (RPKM 32.6) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LPCAT1 in Genome Data Viewer
    Location:
    5p15.33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (1461427..1523960, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (1373271..1435654, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (1461542..1524075, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1511 Neighboring gene MT-CO2 pseudogene 32 Neighboring gene Sharpr-MPRA regulatory region 8068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1386240-1386808 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:1404958-1406157 Neighboring gene solute carrier family 6 member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1412675-1413175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1414882-1415854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1415855-1416827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1422785-1423310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1438947-1439628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1446193-1446692 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:1455983-1457182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1464924-1465753 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1467037-1467537 Neighboring gene uncharacterized LOC124901162 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:1494052-1495251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1500365-1501256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1501257-1502147 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1502148-1503038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1508748-1509266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1509267-1509784 Neighboring gene Sharpr-MPRA regulatory region 9592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1513221-1513780 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1514341-1514899 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1514900-1515460 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1515461-1516020 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1516021-1516580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:1517140-1517700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1521598-1522102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15882 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15884 Neighboring gene microRNA 6075 Neighboring gene CRISPRi-validated cis-regulatory element chr5.422 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:1536432-1536569 Neighboring gene uncharacterized LOC124901161 Neighboring gene uncharacterized LOC107986397 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:1550004-1550504

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12443, FLJ41609

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    lysophosphatidylcholine acyltransferase 1
    Names
    1-acylglycerol-3-phosphate O-acyltransferase
    1-acylglycerophosphocholine O-acyltransferase
    1-alkenylglycerophosphocholine O-acyltransferase
    1-alkylglycerophosphocholine O-acetyltransferase
    LPC acyltransferase 1
    acetyl-CoA:lyso-PAF acetyltransferase
    acetyl-CoA:lyso-platelet-activating factor acetyltransferase
    acyltransferase-like 2
    lyso-PAF acetyltransferase
    lysoPC acyltransferase 1
    lysophospholipid acyltransferase 8
    phosphonoformate immuno-associated protein 3
    NP_079106.3
    XP_005248430.1
    XP_011512434.2
    XP_011512436.1
    XP_047273719.1
    XP_054209495.1
    XP_054209496.1
    XP_054209497.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051622.1 RefSeqGene

      Range
      5018..67551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_024830.5NP_079106.3  lysophosphatidylcholine acyltransferase 1

      See identical proteins and their annotated locations for NP_079106.3

      Status: REVIEWED

      Source sequence(s)
      AB244719, BC020166, BI770498, CA425992, CR982813
      Consensus CDS
      CCDS3864.1
      UniProtKB/Swiss-Prot
      Q1HAQ1, Q7Z4G6, Q8N3U7, Q8NF37, Q8WUL8, Q9GZW6
      UniProtKB/TrEMBL
      A0A0G2JQ62
      Related
      ENSP00000283415.3, ENST00000283415.4
      Conserved Domains (4) summary
      cd07991
      Location:103314
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:58242
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      pfam13499
      Location:421479
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:432483
      EF-hand_8; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      1461427..1523960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005248373.4XP_005248430.1  lysophosphatidylcholine acyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_005248430.1

      UniProtKB/TrEMBL
      A0A0G2JQ62
      Conserved Domains (4) summary
      cd07991
      Location:55266
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:10194
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      pfam13499
      Location:373431
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:384435
      EF-hand_8; EF-hand domain pair
    2. XM_047417763.1XP_047273719.1  lysophosphatidylcholine acyltransferase 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JQ62
    3. XM_011514134.2XP_011512436.1  lysophosphatidylcholine acyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JQ62
      Conserved Domains (4) summary
      cd07991
      Location:62273
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:17201
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      pfam13499
      Location:380438
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:391442
      EF-hand_8; EF-hand domain pair
    4. XM_011514132.2XP_011512434.2  lysophosphatidylcholine acyltransferase 1 isoform X3

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187547.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      8167..48346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      1373271..1435654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353522.1XP_054209497.1  lysophosphatidylcholine acyltransferase 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JQ62
    2. XM_054353521.1XP_054209496.1  lysophosphatidylcholine acyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JQ62
    3. XM_054353520.1XP_054209495.1  lysophosphatidylcholine acyltransferase 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JQ62