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    CLMP CXADR like membrane protein [ Homo sapiens (human) ]

    Gene ID: 79827, updated on 5-Mar-2024

    Summary

    Official Symbol
    CLMPprovided by HGNC
    Official Full Name
    CXADR like membrane proteinprovided by HGNC
    Primary source
    HGNC:HGNC:24039
    See related
    Ensembl:ENSG00000166250 MIM:611693; AllianceGenome:HGNC:24039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACAM; ASAM; CSBM; CSBS
    Summary
    This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome. [provided by RefSeq, Aug 2015]
    Expression
    Broad expression in fat (RPKM 45.1), endometrium (RPKM 20.9) and 17 other tissues See more
    Orthologs
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    Genomic context

    See CLMP in Genome Data Viewer
    Location:
    11q24.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (123069872..123195248, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (123098457..123223763, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (122940580..123065956, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5676 Neighboring gene uncharacterized LOC124902775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4012 Neighboring gene small nucleolar RNA, C/D box 14D Neighboring gene small nucleolar RNA, C/D box 14C Neighboring gene heat shock protein family A (Hsp70) member 8 Neighboring gene Sharpr-MPRA regulatory region 9139 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:123005125-123005345 Neighboring gene FUN14 domain-containing protein 1-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:123037445-123038142 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123038841-123039537 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:123039572-123040404 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:123051287-123051788 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:123051789-123052288 Neighboring gene uncharacterized LOC105369540 Neighboring gene uncharacterized LOC105369539 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:123086968-123087700 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:123089754-123090254 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:123159835-123160336 Neighboring gene U8 small nucleolar RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    CXADR-like membrane protein
    Names
    CAR-like membrane protein
    adipocyte-specific adhesion molecule
    coxsackie- and adenovirus receptor-like membrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042818.2 RefSeqGene

      Range
      5000..130376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_024769.5NP_079045.1  CXADR-like membrane protein precursor

      See identical proteins and their annotated locations for NP_079045.1

      Status: REVIEWED

      Source sequence(s)
      AP000926, AP001970
      Consensus CDS
      CCDS8441.1
      UniProtKB/Swiss-Prot
      Q9H6B4
      Related
      ENSP00000405577.2, ENST00000448775.4
      Conserved Domains (2) summary
      smart00409
      Location:144225
      IG; Immunoglobulin
      cd20960
      Location:13127
      IgV_CAR_like; Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      123069872..123195248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      123098457..123223763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)