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    ZNF322 zinc finger protein 322 [ Homo sapiens (human) ]

    Gene ID: 79692, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF322provided by HGNC
    Official Full Name
    zinc finger protein 322provided by HGNC
    Primary source
    HGNC:HGNC:23640
    See related
    Ensembl:ENSG00000181315 MIM:610847; AllianceGenome:HGNC:23640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCG12; ZNF388; ZNF489; ZNF322A
    Summary
    ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 9.4), thyroid (RPKM 9.3) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF322 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26634383..26659746, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26502803..26528154, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26634611..26659974, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374989 Neighboring gene vomeronasal 1 receptor 14 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26659404-26659904 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26659905-26660405 Neighboring gene uncharacterized LOC102724851 Neighboring gene tRNA-Ala (anticodon AGC) 14-1 Neighboring gene tRNA-Ala (anticodon AGC) 12-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23393

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 322
    Names
    HLA complex group 12
    zinc finger protein 322A
    zinc finger protein 388
    zinc finger protein 489

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242797.2NP_001229726.1  zinc finger protein 322

      See identical proteins and their annotated locations for NP_001229726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL513548, DA481584
      Consensus CDS
      CCDS4617.1
      UniProtKB/Swiss-Prot
      A8K1X3, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9
      Related
      ENSP00000482607.1, ENST00000622479.4
      Conserved Domains (3) summary
      COG5048
      Location:69219
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207291
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:129149
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_001242798.2NP_001229727.1  zinc finger protein 322

      See identical proteins and their annotated locations for NP_001229727.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL513548, DA437716
      Consensus CDS
      CCDS4617.1
      UniProtKB/Swiss-Prot
      A8K1X3, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9
      Related
      ENSP00000483223.1, ENST00000607204.5
      Conserved Domains (3) summary
      COG5048
      Location:69219
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207291
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:129149
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. NM_001242799.2NP_001229728.1  zinc finger protein 322

      See identical proteins and their annotated locations for NP_001229728.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL513548, DB454351
      Consensus CDS
      CCDS4617.1
      UniProtKB/Swiss-Prot
      A8K1X3, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9
      Related
      ENSP00000478899.1, ENST00000456172.5
      Conserved Domains (3) summary
      COG5048
      Location:69219
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207291
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:129149
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. NM_024639.5NP_078915.2  zinc finger protein 322

      See identical proteins and their annotated locations for NP_078915.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK290038, AL513548, BX474628
      Consensus CDS
      CCDS4617.1
      UniProtKB/Swiss-Prot
      A8K1X3, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9
      Related
      ENSP00000418897.1, ENST00000415922.7
      Conserved Domains (3) summary
      COG5048
      Location:69219
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207291
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:129149
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      26634383..26659746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791780.1 Reference GRCh38.p14 PATCHES

      Range
      180572..205907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008485816.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      26502803..26528154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008487434.1 RNA Sequence