U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ZDHHC14 zinc finger DHHC-type palmitoyltransferase 14 [ Homo sapiens (human) ]

    Gene ID: 79683, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZDHHC14provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 14provided by HGNC
    Primary source
    HGNC:HGNC:20341
    See related
    Ensembl:ENSG00000175048 MIM:619295; AllianceGenome:HGNC:20341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEW1CP
    Summary
    Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 2.5), endometrium (RPKM 2.3) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZDHHC14 in Genome Data Viewer
    Location:
    6q25.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (157381190..157678157)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (158623184..158923532)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (157802222..158099189)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene chromosome 18 open reading frame 21 pseudogene Neighboring gene uncharacterized LOC124901446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157800546-157801158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17723 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:157801770-157802381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25331 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr6:157818864-157819364 and GRCh37_chr6:157819365-157819865 Neighboring gene MPRA-validated peak6255 silencer Neighboring gene MPRA-validated peak6257 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:157867979-157868480 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:157868882-157869106 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157876133-157877024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157885378-157885878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157885879-157886379 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157887214-157888001 Neighboring gene MPRA-validated peak6259 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157938365-157938888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157938889-157939410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157951781-157952686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157952687-157953591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157954158-157954658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157954659-157955159 Neighboring gene MPRA-validated peak6260 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157973253-157974075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157977751-157978536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25334 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157982847-157983820 Neighboring gene microRNA 3692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157993864-157994596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158014227-158014728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158014729-158015228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158037061-158037562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158037563-158038062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158066653-158067153 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:158069048-158070247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158090399-158091006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158091007-158091612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158109923-158110424 Neighboring gene uncharacterized LOC107986663 Neighboring gene NANOG hESC enhancer GRCh37_chr6:158127150-158127715 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:158131630-158132829 Neighboring gene uncharacterized LOC124901555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158134197-158134698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158134699-158135198 Neighboring gene NANOG hESC enhancer GRCh37_chr6:158152966-158153487 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158153745-158154270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:158162257-158162797 Neighboring gene Sharpr-MPRA regulatory region 4686 Neighboring gene Sharpr-MPRA regulatory region 7014 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:158183852-158185051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25339 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:158251124-158251862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25340 Neighboring gene Sharpr-MPRA regulatory region 12251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25341 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17728 Neighboring gene sorting nexin 9 Neighboring gene SNX9 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20984

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-L-cysteine S-palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC14
    Names
    DHHC domain-containing cysteine-rich protein 14
    DHHC-14
    NEW1 domain-containing protein
    probable palmitoyltransferase ZDHHC14
    zinc finger DHHC domain-containing protein 14
    zinc finger DHHC-type containing 14
    zinc finger, DHHC domain containing 14
    NP_078906.2
    NP_714968.1
    XP_016866797.1
    XP_016866798.1
    XP_016866799.1
    XP_047275322.1
    XP_047275324.1
    XP_054212412.1
    XP_054212413.1
    XP_054212414.1
    XP_054212415.1
    XP_054212416.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024630.3NP_078906.2  palmitoyltransferase ZDHHC14 isoform 1

      See identical proteins and their annotated locations for NP_078906.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF542388, AL117344, AL133510
      Consensus CDS
      CCDS5252.1
      UniProtKB/Swiss-Prot
      A6NDB7, Q5JS07, Q5JS08, Q6PHS4, Q8IZN2, Q8IZN3, Q9H7F1
      UniProtKB/TrEMBL
      A4FVA9
      Related
      ENSP00000352821.5, ENST00000359775.10
      Conserved Domains (2) summary
      PHA03247
      Location:314485
      PHA03247; large tegument protein UL36; Provisional
      pfam01529
      Location:164287
      DHHC; DHHC palmitoyltransferase
    2. NM_153746.2NP_714968.1  palmitoyltransferase ZDHHC14 isoform 2

      See identical proteins and their annotated locations for NP_714968.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AF542389, AL117344
      Consensus CDS
      CCDS47510.1
      UniProtKB/TrEMBL
      A4FVA9
      Related
      ENSP00000410713.2, ENST00000414563.6
      Conserved Domains (2) summary
      PHA03247
      Location:314470
      PHA03247; large tegument protein UL36; Provisional
      pfam01529
      Location:164287
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      157381190..157678157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419366.1XP_047275322.1  palmitoyltransferase ZDHHC14 isoform X3

    2. XM_017011308.2XP_016866797.1  palmitoyltransferase ZDHHC14 isoform X1

    3. XM_017011309.2XP_016866798.1  palmitoyltransferase ZDHHC14 isoform X2

    4. XM_017011310.2XP_016866799.1  palmitoyltransferase ZDHHC14 isoform X4

    5. XM_047419368.1XP_047275324.1  palmitoyltransferase ZDHHC14 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      158623184..158923532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356439.1XP_054212414.1  palmitoyltransferase ZDHHC14 isoform X3

    2. XM_054356437.1XP_054212412.1  palmitoyltransferase ZDHHC14 isoform X1

    3. XM_054356438.1XP_054212413.1  palmitoyltransferase ZDHHC14 isoform X2

    4. XM_054356440.1XP_054212415.1  palmitoyltransferase ZDHHC14 isoform X4

    5. XM_054356441.1XP_054212416.1  palmitoyltransferase ZDHHC14 isoform X5