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    TTC13 tetratricopeptide repeat domain 13 [ Homo sapiens (human) ]

    Gene ID: 79573, updated on 21-Dec-2019

    Summary

    Official Symbol
    TTC13provided by HGNC
    Official Full Name
    tetratricopeptide repeat domain 13provided by HGNC
    Primary source
    HGNC:HGNC:26204
    See related
    Ensembl:ENSG00000143643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in lymph node (RPKM 8.0), spleen (RPKM 5.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See TTC13 in Genome Data Viewer
    Location:
    1q42.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (230906243..230978872, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (231041987..231114618, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927604 Neighboring gene uncharacterized LOC105373167 Neighboring gene RNA, 7SL, cytoplasmic 837, pseudogene Neighboring gene ARV1 homolog, fatty acid homeostasis modulator Neighboring gene microRNA 1182 Neighboring gene family with sequence similarity 89 member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ22584

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 13
    Names
    TPR repeat protein 13
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122835.3NP_001116307.2  tetratricopeptide repeat protein 13 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the middle portion of the coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AK075386, AK075561, BC047662, DA741498, EL946523
      Consensus CDS
      CCDS44332.2
      UniProtKB/Swiss-Prot
      Q8NBP0
      Related
      ENSP00000355622.4, ENST00000366662.8
      Conserved Domains (4) summary
      sd00006
      Location:196224
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:264297
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:229294
      TPR_11; TPR repeat
      pfam13424
      Location:149228
      TPR_12; Tetratricopeptide repeat
    2. NM_001376507.1NP_001363436.1  tetratricopeptide repeat protein 13 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
    3. NM_001376508.1NP_001363437.1  tetratricopeptide repeat protein 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
    4. NM_001376509.1NP_001363438.1  tetratricopeptide repeat protein 13 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
    5. NM_001376510.1NP_001363439.1  tetratricopeptide repeat protein 13 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
    6. NM_001376511.1NP_001363440.1  tetratricopeptide repeat protein 13 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
    7. NM_001376512.1NP_001363441.1  tetratricopeptide repeat protein 13 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
    8. NM_001376513.1NP_001363442.1  tetratricopeptide repeat protein 13 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
    9. NM_001376514.1NP_001363443.1  tetratricopeptide repeat protein 13 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL844165, FO393421
    10. NM_024525.5NP_078801.3  tetratricopeptide repeat protein 13 isoform a

      See identical proteins and their annotated locations for NP_078801.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK074365, AK075386, AK075561, DA468037, DA741498, EL946523
      Consensus CDS
      CCDS1588.1
      UniProtKB/Swiss-Prot
      Q8NBP0
      Related
      ENSP00000355621.4, ENST00000366661.9
      Conserved Domains (2) summary
      sd00006
      Location:249277
      TPR; TPR repeat [structural motif]
      cl26002
      Location:119418
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      230906243..230978872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002325.1XP_016857814.1  tetratricopeptide repeat protein 13 isoform X13

      Conserved Domains (2) summary
      sd00006
      Location:2656
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:358
      TPR_11; TPR repeat
    2. XM_005273264.2XP_005273321.1  tetratricopeptide repeat protein 13 isoform X5

      Conserved Domains (3) summary
      sd00006
      Location:241269
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:241274
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:242306
      TPR_11; TPR repeat
    3. XM_006711815.3XP_006711878.1  tetratricopeptide repeat protein 13 isoform X12

      See identical proteins and their annotated locations for XP_006711878.1

      Conserved Domains (2) summary
      sd00006
      Location:2656
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:358
      TPR_11; TPR repeat
    4. XM_011544276.2XP_011542578.1  tetratricopeptide repeat protein 13 isoform X11

      Conserved Domains (3) summary
      sd00006
      Location:1949
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:2053
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:2185
      TPR_11; TPR repeat
    5. XM_006711814.2XP_006711877.1  tetratricopeptide repeat protein 13 isoform X7

      Conserved Domains (4) summary
      sd00006
      Location:188216
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:188221
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:189253
      TPR_11; TPR repeat
      pfam13424
      Location:149215
      TPR_12; Tetratricopeptide repeat

    RNA

    1. XR_001737405.1 RNA Sequence

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