U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ULBP3 UL16 binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 79465, updated on 5-Mar-2024

    Summary

    Official Symbol
    ULBP3provided by HGNC
    Official Full Name
    UL16 binding protein 3provided by HGNC
    Primary source
    HGNC:HGNC:14895
    See related
    Ensembl:ENSG00000131019 MIM:605699; AllianceGenome:HGNC:14895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    N2DL-3; RAET1N; NKG2DL3
    Summary
    The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015]
    Expression
    Broad expression in testis (RPKM 3.9), thyroid (RPKM 2.5) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ULBP3 in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (150061053..150069121, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (151260425..151268490, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150382189..150390257, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene retinoic acid early transcript 1M (pseudogene) Neighboring gene PHB1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25272 Neighboring gene uncharacterized LOC124901428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150391279-150392146 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14C Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
    EBI GWAS Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif A3G upregulates NKG2D ligands through an ATM pathway and in which HIV-1 Vif counteracts this upregulation by decreasing A3G expression PubMed
    vif Vpr-dependent induction and Vif-mediated attenuation of NKG2D ligands are required for Chk2 phosphorylation in HIV infection PubMed
    vif HIV-1 Vif expression in HIV-1 infected cells results in less HIV-1 Vpr-dependent upregulation of NKG2D ligands PubMed
    Vpr vpr HIV-1-Vpr induced upregulation of NKG2D ligands in HIV-infected T cells by activating UNG2-dependent repair of uridine-containing DNA PubMed
    vpr HIV-1 Vpr upregulates NKG2D ligands via the ATR pathway PubMed
    vpr Vpr-dependent induction and Vif-mediated attenuation of NKG2D ligands are required for Chk2 phosphorylation in HIV infection PubMed
    vpr HIV-1 Vif expression in HIV-1 infected cells results in less HIV-1 Vpr-dependent upregulation of NKG2D ligands PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables natural killer cell lectin-like receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    UL16-binding protein 3
    Names
    ALCAN-gamma
    NKG2D ligand 3
    retinoic acid early transcript 1N

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024518.3NP_078794.1  UL16-binding protein 3

      See identical proteins and their annotated locations for NP_078794.1

      Status: REVIEWED

      Source sequence(s)
      AK315275, AL355497, CA488356
      Consensus CDS
      CCDS5225.1
      UniProtKB/Swiss-Prot
      Q5VY82, Q8IZX5, Q8TE75, Q9BZM4
      Related
      ENSP00000356308.1, ENST00000367339.7
      Conserved Domains (1) summary
      cl08246
      Location:32206
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      150061053..150069121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      151260425..151268490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)