U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    WDR25 WD repeat domain 25 [ Homo sapiens (human) ]

    Gene ID: 79446, updated on 17-Jun-2024

    Summary

    Official Symbol
    WDR25provided by HGNC
    Official Full Name
    WD repeat domain 25provided by HGNC
    Primary source
    HGNC:HGNC:21064
    See related
    Ensembl:ENSG00000176473 MIM:618059; AllianceGenome:HGNC:21064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C14orf67
    Summary
    This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved in protein-protein interactions in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.8), testis (RPKM 2.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See WDR25 in Genome Data Viewer
    Location:
    14q32.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (100376485..100530303)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (94609583..94764104)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (100842822..100996640)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9038 Neighboring gene solute carrier family 25 member 47 Neighboring gene tryptophanyl-tRNA synthetase 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100837597-100838513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6091 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100848141-100849101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100849328-100849837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100860083-100860587 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:100863901-100865100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100870227-100870728 Neighboring gene uncharacterized LOC105370664 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:100876203-100876704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:100876705-100877204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100885967-100886468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100886469-100886968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100893614-100894278 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:100904917-100906116 Neighboring gene Sharpr-MPRA regulatory region 12420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100913795-100914295 Neighboring gene uncharacterized LOC124903383 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100932314-100933219 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100966138-100966638 Neighboring gene RN7SK pseudogene 92 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100989077-100989737 Neighboring gene uncharacterized LOC124903382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9041 Neighboring gene uncharacterized LOC124903384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101021873-101022628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101022629-101023385 Neighboring gene brain enriched guanylate kinase associated

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    WD repeat-containing protein 25
    Names
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053195.1 RefSeqGene

      Range
      5076..158894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161476.3NP_001154948.1  WD repeat-containing protein 25 isoform a

      See identical proteins and their annotated locations for NP_001154948.1

      Status: REVIEWED

      Source sequence(s)
      AL135838, AL845552
      Consensus CDS
      CCDS32157.1
      UniProtKB/Swiss-Prot
      A8K7E5, Q64LD2, Q6NVV6, Q86TQ4, Q9BTK5
      UniProtKB/TrEMBL
      A0A384NPW5
      Related
      ENSP00000385540.3, ENST00000402312.8
      Conserved Domains (2) summary
      sd00039
      Location:251290
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:239543
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001350947.2NP_001337876.1  WD repeat-containing protein 25 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL135838, AL845552
      Consensus CDS
      CCDS32157.1
      UniProtKB/Swiss-Prot
      A8K7E5, Q64LD2, Q6NVV6, Q86TQ4, Q9BTK5
      UniProtKB/TrEMBL
      A0A384NPW5
      Conserved Domains (2) summary
      sd00039
      Location:251290
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:239543
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001350948.2NP_001337877.1  WD repeat-containing protein 25 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL135838, AL845552
      Consensus CDS
      CCDS32157.1
      UniProtKB/Swiss-Prot
      A8K7E5, Q64LD2, Q6NVV6, Q86TQ4, Q9BTK5
      UniProtKB/TrEMBL
      A0A384NPW5
      Related
      ENSP00000450661.1, ENST00000554998.5
      Conserved Domains (2) summary
      sd00039
      Location:251290
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:239543
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_001350949.2NP_001337878.1  WD repeat-containing protein 25 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL135838, AL845552
      Conserved Domains (2) summary
      sd00039
      Location:4680
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:15293
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. NM_001387351.1NP_001374280.1  WD repeat-containing protein 25 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL135838, AL845552
      Related
      ENSP00000441903.2, ENST00000542471.2
      Conserved Domains (2) summary
      sd00039
      Location:4680
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:15293
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. NM_024515.6NP_078791.3  WD repeat-containing protein 25 isoform a

      See identical proteins and their annotated locations for NP_078791.3

      Status: REVIEWED

      Source sequence(s)
      AL135838, AL845552, AY295082, BG705426, HY044677
      Consensus CDS
      CCDS32157.1
      UniProtKB/Swiss-Prot
      A8K7E5, Q64LD2, Q6NVV6, Q86TQ4, Q9BTK5
      UniProtKB/TrEMBL
      A0A384NPW5
      Related
      ENSP00000334148.6, ENST00000335290.10
      Conserved Domains (2) summary
      sd00039
      Location:251290
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:239543
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      100376485..100530303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431772.1XP_047287728.1  WD repeat-containing protein 25 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      94609583..94764104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001350950.1: Suppressed sequence

      Description
      NM_001350950.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.