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    CENPO centromere protein O [ Homo sapiens (human) ]

    Gene ID: 79172, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CENPOprovided by HGNC
    Official Full Name
    centromere protein Oprovided by HGNC
    Primary source
    HGNC:HGNC:28152
    See related
    Ensembl:ENSG00000138092 MIM:611504; AllianceGenome:HGNC:28152
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CENP-O; MCM21R; ICEN-36
    Summary
    This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in placenta (RPKM 11.4), testis (RPKM 8.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2p23.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (24793425..24822376)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (24828225..24857125)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (25016294..25045245)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 1 Neighboring gene RNA, U6 small nuclear 936, pseudogene Neighboring gene uncharacterized LOC105369164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15435 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25044835-25045378 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25045379-25045923 Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25048335-25048894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25048895-25049453 Neighboring gene uncharacterized LOC105377626 Neighboring gene Sharpr-MPRA regulatory region 9030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25056543-25057467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25057468-25058391 Neighboring gene adenylate cyclase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25097035-25097779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25121605-25122524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25126133-25126634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25126635-25127134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11235 Neighboring gene uncharacterized LOC124907742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11238

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CENPO expression regulates gastric cancer cell proliferation and is associated with poor patient prognosis. Cao Y, et al. Mol Med Rep, 2019 Oct. PMID 31485675, Free PMC Article
    2. CENP-O, a protein localized at the centromere throughout the cell cycle, is a novel target antigen in systemic sclerosis. Saito A, et al. J Rheumatol, 2009 Apr. PMID 19286853
    3. Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly. Toso A, et al. J Cell Biol, 2009 Feb 9. PMID 19204145, Free PMC Article
    4. The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. McAinsh AD, et al. EMBO J, 2006 Sep 6. PMID 16932742, Free PMC Article
    5. The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity. McClelland SE, et al. EMBO J, 2007 Dec 12. PMID 18007590, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prognostic and immune infiltrative biomarkers of CENPO in pan-cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis.
      Title: Prognostic and immune infiltrative biomarkers of CENPO in pan-cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis.
    2. Differential requirements for the CENP-O complex reveal parallel PLK1 kinetochore recruitment pathways.
      Title: Differential requirements for the CENP-O complex reveal parallel PLK1 kinetochore recruitment pathways.
    3. Knockdown of CENPO contributed to Gastric Cancer cell growth inhibition and apoptosis induction.
      Title: CENPO expression regulates gastric cancer cell proliferation and is associated with poor patient prognosis.
    4. Data propose that CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step that could be important for kinetochores switching into the correct conformation for microtubule-attachment.
      Title: Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. CENP-O protein is a novel centromere antigen that is recognized by a very minor population of ACA-positive patients with scleroderma.
      Title: CENP-O, a protein localized at the centromere throughout the cell cycle, is a novel target antigen in systemic sclerosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11266

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centromere complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Mis6-Sim4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of inner kinetochore IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein O
    Names
    centromeric protein O
    interphase centromere complex protein 36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199803.3 → NP_001186732.1  centromere protein O isoform 2

      See identical proteins and their annotated locations for NP_001186732.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC012073, AK027859, BX110829
      Consensus CDS
      CCDS56113.1
      UniProtKB/Swiss-Prot
      Q9BU64
      Related
      ENSP00000417787.1, ENST00000473706.5
      Conserved Domains (1) summary
      pfam09496
      Location:140 → 163
      CENP-O; Cenp-O kinetochore centromere component

    2. NM_001322101.2 → NP_001309030.1  centromere protein O isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) and variant 1 both encode isoform 1.
      Source sequence(s)
      AC012073, AK027859, BX110829, BX406097, CF993857
      Consensus CDS
      CCDS1714.1
      UniProtKB/Swiss-Prot
      B2RDC0, D6W536, Q53T55, Q96JV3, Q9BU64
      Related
      ENSP00000370214.2, ENST00000380834.7
      Conserved Domains (1) summary
      pfam09496
      Location:146 → 169
      CENP-O; Cenp-O kinetochore centromere component

    3. NM_024322.4 → NP_077298.1  centromere protein O isoform 1

      See identical proteins and their annotated locations for NP_077298.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 both encode isoform 1.
      Source sequence(s)
      AC012073, BC002870, BX110829, CF993857
      Consensus CDS
      CCDS1714.1
      UniProtKB/Swiss-Prot
      B2RDC0, D6W536, Q53T55, Q96JV3, Q9BU64
      Related
      ENSP00000260662.1, ENST00000260662.2
      Conserved Domains (1) summary
      pfam09496
      Location:146 → 169
      CENP-O; Cenp-O kinetochore centromere component

    RNA

    1. NR_136182.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012073, AK027859, BX110829, CF993857, CN263048, CX872478

    2. NR_136183.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012073, AK027859, BX110829, CF993857, CN263048

    3. NR_136184.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC012073, AK027859, BX110829, CF993857, CX872478

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      24793425..24822376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      24828225..24857125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BU64.1 GenPept UniProtKB/Swiss-Prot:Q9BU64

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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