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    NOL12 nucleolar protein 12 [ Homo sapiens (human) ]

    Gene ID: 79159, updated on 17-Sep-2024

    Summary

    Official Symbol
    NOL12provided by HGNC
    Official Full Name
    nucleolar protein 12provided by HGNC
    Primary source
    HGNC:HGNC:28585
    See related
    Ensembl:ENSG00000273899 AllianceGenome:HGNC:28585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Nop25; dJ37E16.7
    Summary
    Enables identical protein binding activity. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 6.5), skin (RPKM 5.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NOL12 in Genome Data Viewer
    Location:
    22q13.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37686343..37693474)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38147595..38154723)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38082350..38089481)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 385, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38073459-38074269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38077520-38078020 Neighboring gene galectin 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38081369-38082310 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38082311-38083251 Neighboring gene TRIO and F-actin binding protein Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38108187-38108370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38121829-38122330 Neighboring gene uncharacterized LOC124905115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38136652-38137169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38137170-38137686 Neighboring gene uncharacterized LOC102724378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13697 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:38147547-38148746 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:38150829-38152028 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38153498-38153662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38158448-38158948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38177743-38178242 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of nucleolar protein 12 (NOL12) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    nucleocapsid gag HIV-1 NC is identified to have a physical interaction with nucleolar protein 12 (NOL12) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: TRIOBP

    Clone Names

    • MGC3731, FLJ34609

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024313.3NP_077289.1  nucleolar protein 12

      See identical proteins and their annotated locations for NP_077289.1

      Status: VALIDATED

      Source sequence(s)
      BC002808, BE241845, Z83844
      Consensus CDS
      CCDS13955.1
      UniProtKB/Swiss-Prot
      Q9UGY1
      UniProtKB/TrEMBL
      B3KQ09
      Related
      ENSP00000352021.4, ENST00000359114.9
      Conserved Domains (1) summary
      pfam09805
      Location:2067
      Nop25; Nucleolar protein 12 (25kDa)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      37686343..37693474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      38147595..38154723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)