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    GSK3B glycogen synthase kinase 3 beta [ Bos taurus (domestic cattle) ]

    Gene ID: 790875, updated on 10-Feb-2026
    Official Symbol
    GSK3Bprovided by VGNC
    Official Full Name
    glycogen synthase kinase 3 betaprovided by VGNC
    Primary source
    VGNC:VGNC:106762
    See related
    EnsemblRapid:ENSBTAG00070014348
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    GSK3beta
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See GSK3B in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (64641316..64861897, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 91 Neighboring gene nuclear receptor subfamily 1 group I member 2 Neighboring gene microRNA mir-6529b Neighboring gene microRNA mir-6529a Neighboring gene G protein-coupled receptor 156 Neighboring gene late histone H2B.L4-like Neighboring gene uncharacterized LOC101906506

    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Related articles in PubMed

    1. Role and regulation of Glycogen synthase kinase-3 beta in bovine spermatozoa. Belenky M, et al. Mol Reprod Dev, 2017 Jan. PMID 27864906
    2. GSK3β regulates milk synthesis in and proliferation of dairy cow mammary epithelial cells via the mTOR/S6K1 signaling pathway. Zhang X, et al. Molecules, 2014 Jul 3. PMID 24995926, Free PMC Article
    3. Identification and regulation of glycogen synthase kinase-3 during bovine embryo development. Aparicio IM, et al. Reproduction, 2010 Jul. PMID 20427566
    4. Convergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesis. Roy L, et al. Endocrinology, 2009 Nov. PMID 19819952, Free PMC Article
    5. Biochemical characterization of phospholipids, sulfatide and heparin as potent stimulators for autophosphorylation of GSK-3beta and the GSK-3beta-mediated phosphorylation of myelin basic protein in vitro. Kawakami F, et al. J Biochem, 2008 Mar. PMID 18039685

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that maintenance of sperm motility and acrosome reaction timing are mediated by PKA through the regulation of GSK-3 beta activity.
      Title: Role and regulation of Glycogen synthase kinase-3 beta in bovine spermatozoa.
    2. GSK3B and phosphorylated GSK3B regulate milk synthesis and proliferation dairy cow mammary epithelial cells.
      Title: GSK3β regulates milk synthesis in and proliferation of dairy cow mammary epithelial cells via the mTOR/S6K1 signaling pathway.
    3. results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
      Title: Nav1.7-Ca2+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK) and p38 attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK and p38.
    4. GSK3B serine phosphorylation was positively correlated with embryo development
      Title: Identification and regulation of glycogen synthase kinase-3 during bovine embryo development.
    5. IGF-I down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.
      Title: Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3beta and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation.
    6. cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
      Title: Convergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesis.
    7. These results suggest that phospholipids and sulfatide and heparin may function as effective stimulators for autophosphorylation of GSK-3beta and for the GSK-3beta-mediated phosphorylation of SH-binding proteins, including MBP and tau protein.
      Title: Biochemical characterization of phospholipids, sulfatide and heparin as potent stimulators for autophosphorylation of GSK-3beta and the GSK-3beta-mediated phosphorylation of myelin basic protein in vitro.
    Submit: New GeneRIF Correction
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tau-protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of beta-catenin destruction complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    glycogen synthase kinase-3 beta
    Names
    GSK-3beta
    NP_001094780.1
    XP_024848670.1
    XP_024848671.1
    XP_059743257.1
    XP_059743258.1

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101310.1 → NP_001094780.1  glycogen synthase kinase-3 beta

      See identical proteins and their annotated locations for NP_001094780.1

      Status: PROVISIONAL

      Source sequence(s)
      BC146176
      UniProtKB/TrEMBL
      A0AAA9T207, A6H7A9
      Related
      ENSBTAP00070019049.1, ENSBTAT00070032484.1
      Conserved Domains (2) summary
      cd14137
      Location:51 → 356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
      pfam00069
      Location:56 → 353
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      64641316..64861897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024992902.2 → XP_024848670.1  glycogen synthase kinase-3 beta isoform X1

      UniProtKB/TrEMBL
      A0AAA9T207
      Conserved Domains (1) summary
      cd14137
      Location:51 → 343
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    2. XM_059887275.1 → XP_059743258.1  glycogen synthase kinase-3 beta isoform X3

      UniProtKB/TrEMBL
      F1MIC3

    3. XM_024992903.2 → XP_024848671.1  glycogen synthase kinase-3 beta isoform X4

      UniProtKB/TrEMBL
      A0AAA9T207
      Conserved Domains (1) summary
      cd14137
      Location:51 → 356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    4. XM_059887274.1 → XP_059743257.1  glycogen synthase kinase-3 beta isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MT31, A0AAA9T207
      Related
      ENSBTAP00070019033.1, ENSBTAT00070032459.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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