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    SLC25A23 solute carrier family 25 member 23 [ Homo sapiens (human) ]

    Gene ID: 79085, updated on 17-Jun-2024

    Summary

    Official Symbol
    SLC25A23provided by HGNC
    Official Full Name
    solute carrier family 25 member 23provided by HGNC
    Primary source
    HGNC:HGNC:19375
    See related
    Ensembl:ENSG00000125648 MIM:608746; AllianceGenome:HGNC:19375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APC2; MCSC2; SCAMC3; SCaMC-3
    Summary
    Predicted to enable ATP transmembrane transporter activity. Involved in calcium import into the mitochondrion; positive regulation of mitochondrial calcium ion concentration; and regulation of cellular hyperosmotic salinity response. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 40.2), thyroid (RPKM 28.7) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC25A23 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6436081..6459792, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6425594..6449293, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6440075..6459803, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adenylate kinase isoenzyme 1-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6411708-6412532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6412533-6413357 Neighboring gene KH-type splicing regulatory protein Neighboring gene microRNA 3940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13824 Neighboring gene solute carrier family 25 member 41 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6464149-6464690 Neighboring gene DENN domain containing 1C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6475606-6476345 Neighboring gene crumbs cell polarity complex component 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6479893-6480392 Neighboring gene Sharpr-MPRA regulatory region 5032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9956 Neighboring gene tubulin beta 4A class IVa

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC2615

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP:phosphate antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP:phosphate antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables adenine nucleotide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    mitochondrial adenyl nucleotide antiporter SLC25A23
    Names
    calcium-binding mitochondrial carrier protein SCaMC-3
    mitochondrial ATP-Mg/Pi carrier protein 2
    mitochondrial Ca(2+)-dependent solute carrier protein 2
    mitochondrial Ca2+-dependent solute carrier protein 2
    short calcium-binding mitochondrial carrier 3
    short calcium-binding mitochondrial carrier protein 3
    small calcium-binding mitochondrial carrier protein 3
    solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024103.3NP_077008.2  mitochondrial adenyl nucleotide antiporter SLC25A23

      See identical proteins and their annotated locations for NP_077008.2

      Status: VALIDATED

      Source sequence(s)
      AC010503, AJ619962, AW379976, BC001656, BG706035
      Consensus CDS
      CCDS32882.1
      UniProtKB/Swiss-Prot
      B4DGB6, Q4LBC2, Q705K3, Q86Y43, Q8N2N4, Q96NQ4, Q9BV35
      Related
      ENSP00000301454.3, ENST00000301454.9
      Conserved Domains (3) summary
      COG5126
      Location:7143
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd15897
      Location:1245
      EFh_PEF; EF-hand motif [structural motif]
      cl28162
      Location:190463
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      6436081..6459792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439413.1XP_047295369.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X30

    2. XM_047439412.1XP_047295368.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X27

    3. XM_017027287.3XP_016882776.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X14

    4. XM_017027292.3XP_016882781.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X29

    5. XM_047439410.1XP_047295366.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X25

    6. XM_047439407.1XP_047295363.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X20

    7. XM_017027286.3XP_016882775.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X11

    8. XM_047439408.1XP_047295364.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X22

      Related
      ENSP00000334537.4, ENST00000334510.9
    9. XM_047439406.1XP_047295362.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X19

    10. XM_017027288.3XP_016882777.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X15

    11. XM_011528275.3XP_011526577.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X2

      Conserved Domains (4) summary
      cd00051
      Location:85142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      PTZ00169
      Location:190463
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:275364
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:1675
      EF-hand_7; EF-hand domain pair
    12. XM_047439411.1XP_047295367.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X26

    13. XM_011528279.3XP_011526581.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X9

      Conserved Domains (3) summary
      cd00051
      Location:85142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00153
      Location:232319
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:1675
      EF-hand_7; EF-hand domain pair
    14. XM_047439409.1XP_047295365.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X23

    15. XM_047439405.1XP_047295361.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X16

    16. XM_011528276.3XP_011526578.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X3

      Conserved Domains (4) summary
      cd00051
      Location:85142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      PTZ00169
      Location:237454
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:232319
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:1675
      EF-hand_7; EF-hand domain pair
    17. XM_011528284.3XP_011526586.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X17

      Related
      ENSP00000264088.3, ENST00000264088.8
      Conserved Domains (3) summary
      cd00051
      Location:85142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00153
      Location:322411
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:1675
      EF-hand_7; EF-hand domain pair
    18. XM_011528282.3XP_011526584.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X12

      Conserved Domains (3) summary
      cd00051
      Location:85142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00153
      Location:322411
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:1675
      EF-hand_7; EF-hand domain pair
    19. XM_011528280.3XP_011526582.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X10

      Conserved Domains (3) summary
      cd00051
      Location:85142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00153
      Location:322411
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:1675
      EF-hand_7; EF-hand domain pair
    20. XM_011528283.3XP_011526585.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X13

      Conserved Domains (3) summary
      cd00051
      Location:85142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00153
      Location:322411
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:82137
      EF-hand_7; EF-hand domain pair
    21. XM_047439404.1XP_047295360.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X8

    22. XM_017027285.3XP_016882774.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X4

    23. XM_011528278.3XP_011526580.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X7

      Conserved Domains (4) summary
      cd00051
      Location:85142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      PTZ00169
      Location:237510
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:322411
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:1675
      EF-hand_7; EF-hand domain pair
    24. XM_011528277.3XP_011526579.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X5

      Conserved Domains (4) summary
      cd00051
      Location:85142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      PTZ00169
      Location:237510
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:322411
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:1675
      EF-hand_7; EF-hand domain pair
    25. XM_011528274.3XP_011526576.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X1

      Conserved Domains (4) summary
      cd00051
      Location:85142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      PTZ00169
      Location:237510
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:322411
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:1675
      EF-hand_7; EF-hand domain pair
    26. XM_047439403.1XP_047295359.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X6

    27. XM_017027291.3XP_016882780.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X28

      Conserved Domains (3) summary
      COG5126
      Location:7143
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam00153
      Location:185272
      Mito_carr; Mitochondrial carrier protein
      cd15897
      Location:1245
      EFh_PEF; EF-hand motif [structural motif]
    28. XM_017027290.3XP_016882779.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X24

      Conserved Domains (3) summary
      COG5126
      Location:7143
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam00153
      Location:185272
      Mito_carr; Mitochondrial carrier protein
      cd15897
      Location:1245
      EFh_PEF; EF-hand motif [structural motif]
    29. XM_017027289.3XP_016882778.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X21

    30. XM_011528285.3XP_011526587.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X18

      Conserved Domains (4) summary
      cd00051
      Location:85142
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      PTZ00169
      Location:237454
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:232319
      Mito_carr; Mitochondrial carrier protein
      pfam13499
      Location:1675
      EF-hand_7; EF-hand domain pair

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      6425594..6449293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322113.1XP_054178088.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X30

    2. XM_054322110.1XP_054178085.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X27

    3. XM_054322097.1XP_054178072.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X14

    4. XM_054322112.1XP_054178087.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X29

    5. XM_054322108.1XP_054178083.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X25

    6. XM_054322103.1XP_054178078.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X20

    7. XM_054322094.1XP_054178069.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X11

    8. XM_054322105.1XP_054178080.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X22

    9. XM_054322102.1XP_054178077.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X19

    10. XM_054322098.1XP_054178073.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X15

    11. XM_054322085.1XP_054178060.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X2

    12. XM_054322109.1XP_054178084.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X26

    13. XM_054322092.1XP_054178067.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X9

    14. XM_054322106.1XP_054178081.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X23

    15. XM_054322099.1XP_054178074.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X16

    16. XM_054322086.1XP_054178061.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X3

    17. XM_054322100.1XP_054178075.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X17

    18. XM_054322095.1XP_054178070.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X12

    19. XM_054322093.1XP_054178068.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X10

    20. XM_054322096.1XP_054178071.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X13

    21. XM_054322091.1XP_054178066.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X8

    22. XM_054322087.1XP_054178062.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X4

    23. XM_054322090.1XP_054178065.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X7

    24. XM_054322088.1XP_054178063.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X5

    25. XM_054322084.1XP_054178059.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X1

    26. XM_054322089.1XP_054178064.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X6

    27. XM_054322111.1XP_054178086.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X28

    28. XM_054322107.1XP_054178082.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X24

    29. XM_054322104.1XP_054178079.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X21

    30. XM_054322101.1XP_054178076.1  mitochondrial adenyl nucleotide antiporter SLC25A23 isoform X18