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    WDR77 WD repeat domain 77 [ Homo sapiens (human) ]

    Gene ID: 79084, updated on 30-Apr-2024

    Summary

    Official Symbol
    WDR77provided by HGNC
    Official Full Name
    WD repeat domain 77provided by HGNC
    Primary source
    HGNC:HGNC:29652
    See related
    Ensembl:ENSG00000116455 MIM:611734; AllianceGenome:HGNC:29652
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p44; MEP50; MEP-50; HKMT1069; Nbla10071; p44/Mep50
    Summary
    The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in lymph node (RPKM 14.0), urinary bladder (RPKM 11.8) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See WDR77 in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (111439890..111449256, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (111454574..111463940, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (111982512..111991878, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904309 Neighboring gene NANOG hESC enhancer GRCh37_chr1:111958109-111958610 Neighboring gene oviductal glycoprotein 1 Neighboring gene UBE2F pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1496 Neighboring gene ATP synthase peripheral stalk-membrane subunit b Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1497 Neighboring gene chromosome 1 open reading frame 162

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC2722

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear receptor coactivator activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Cul4B-RING E3 ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of methylosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of methylosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    methylosome protein WDR77
    Names
    WD repeat-containing protein 77
    androgen receptor cofactor p44
    methylosome protein 50
    testis tissue sperm-binding protein Li 44a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317062.2NP_001303991.1  methylosome protein WDR77 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL390195, BC016946, BI195029, DB105102
      UniProtKB/TrEMBL
      H0Y711
      Related
      ENSP00000409300.1, ENST00000449340.1
      Conserved Domains (3) summary
      COG2319
      Location:98341
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:128164
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:80331
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001317063.2NP_001303992.1  methylosome protein WDR77 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice junctions in the 3' end compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL390195, AL557974, BC016946, DB105102
      UniProtKB/TrEMBL
      H0Y711
      Conserved Domains (3) summary
      COG2319
      Location:98327
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:128164
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:80317
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001317064.2NP_001303993.1  methylosome protein WDR77 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame segment in the 5' end and uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK298179, BC016946, DB105102
      UniProtKB/Swiss-Prot
      Q9BQA1
      Conserved Domains (3) summary
      COG2319
      Location:87258
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:106143
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:88258
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_024102.4NP_077007.1  methylosome protein WDR77 isoform 2

      See identical proteins and their annotated locations for NP_077007.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC016946, DB105102
      Consensus CDS
      CCDS835.1
      UniProtKB/Swiss-Prot
      B3KMW6, B4DP38, Q3LID2, Q53FU2, Q6JZZ5, Q96GK4, Q9BQA1, Q9BWY3
      UniProtKB/TrEMBL
      A0A024R0H7, A0A140VKC7, H0Y711
      Related
      ENSP00000235090.5, ENST00000235090.10
      Conserved Domains (3) summary
      COG2319
      Location:98329
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:128164
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:80319
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_133654.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon in the 5' end and uses an alternate splice junction in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK296163, BC016946, DB105102

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      111439890..111449256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      111454574..111463940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)