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    Spsb3 splA/ryanodine receptor domain and SOCS box containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 79043, updated on 16-Oct-2021

    Summary

    Official Symbol
    Spsb3provided by MGI
    Official Full Name
    splA/ryanodine receptor domain and SOCS box containing 3provided by MGI
    Primary source
    MGI:MGI:1891471
    See related
    Ensembl:ENSMUSG00000024160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SSB3; Tce1; mKIAA4204; 2310012N15Rik; 3300001M01Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 50.0), thymus adult (RPKM 39.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Spsb3 in Genome Data Viewer
    Location:
    17; 17 A3.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25104956..25111124)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24885982..24892150)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (25023619..25029092)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene predicted gene, 41549 Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene nucleotide binding protein 2 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4204

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    SPRY domain-containing SOCS box protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163750.1NP_001157222.1  SPRY domain-containing SOCS box protein 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK220234, BY276751
      Consensus CDS
      CCDS50022.1
      UniProtKB/Swiss-Prot
      Q571F5
      UniProtKB/TrEMBL
      E9PW49
      Related
      ENSMUSP00000126878.2, ENSMUST00000168265.8
      Conserved Domains (2) summary
      cd12876
      Location:250432
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:422458
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    2. NM_001163751.1NP_001157223.1  SPRY domain-containing SOCS box protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK082768, AK220234, BY276751
      UniProtKB/Swiss-Prot
      Q571F5
      Conserved Domains (2) summary
      cd12876
      Location:135317
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:307343
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    3. NM_001374602.1NP_001361531.1  SPRY domain-containing SOCS box protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC166102
      Conserved Domains (2) summary
      cd12876
      Location:104286
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:276312
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    4. NM_027141.2NP_081417.2  SPRY domain-containing SOCS box protein 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK009325, BC072556
      Consensus CDS
      CCDS28501.1
      UniProtKB/Swiss-Prot
      Q571F5
      Related
      ENSMUSP00000024976.5, ENSMUST00000024976.5
      Conserved Domains (2) summary
      cd12876
      Location:139321
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:311347
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    RNA

    1. NR_152137.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166102, BC072556

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25104956..25111124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525170.5XP_006525233.1  SPRY domain-containing SOCS box protein 3 isoform X6

      See identical proteins and their annotated locations for XP_006525233.1

      UniProtKB/TrEMBL
      D3YW96
      Related
      ENSMUSP00000112589.2, ENSMUST00000119829.8
      Conserved Domains (2) summary
      cd12876
      Location:104311
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:301337
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    2. XM_006525169.4XP_006525232.1  SPRY domain-containing SOCS box protein 3 isoform X5

      Conserved Domains (2) summary
      cd12876
      Location:135342
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:332368
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    3. XM_030250150.1XP_030106010.1  SPRY domain-containing SOCS box protein 3 isoform X7

      Related
      ENSMUSP00000068567.7, ENSMUST00000068508.13
      Conserved Domains (1) summary
      cd12876
      Location:135274
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    4. XM_030250149.2XP_030106009.1  SPRY domain-containing SOCS box protein 3 isoform X3

      Conserved Domains (1) summary
      cd12876
      Location:250389
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    5. XM_006525165.4XP_006525228.1  SPRY domain-containing SOCS box protein 3 isoform X1

      Conserved Domains (2) summary
      cd12876
      Location:250457
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:447483
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    6. XM_006525166.5XP_006525229.1  SPRY domain-containing SOCS box protein 3 isoform X2

      Conserved Domains (1) summary
      cd12876
      Location:250414
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    7. XM_030250151.1XP_030106011.1  SPRY domain-containing SOCS box protein 3 isoform X8

      Related
      ENSMUSP00000112492.2, ENSMUST00000120943.8
      Conserved Domains (2) summary
      cd12876
      Location:104286
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:276312
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    8. XM_011246733.3XP_011245035.1  SPRY domain-containing SOCS box protein 3 isoform X6

      See identical proteins and their annotated locations for XP_011245035.1

      UniProtKB/TrEMBL
      D3YW96
      Conserved Domains (2) summary
      cd12876
      Location:104311
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:301337
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    9. XM_006525168.5XP_006525231.1  SPRY domain-containing SOCS box protein 3 isoform X4

      Conserved Domains (2) summary
      cd12876
      Location:139346
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:336372
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    10. XM_030250153.1XP_030106013.1  SPRY domain-containing SOCS box protein 3 isoform X9

      Conserved Domains (2) summary
      cd12876
      Location:1183
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:173209
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
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