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    ZFYVE21 zinc finger FYVE-type containing 21 [ Homo sapiens (human) ]

    Gene ID: 79038, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZFYVE21provided by HGNC
    Official Full Name
    zinc finger FYVE-type containing 21provided by HGNC
    Primary source
    HGNC:HGNC:20760
    See related
    Ensembl:ENSG00000100711 MIM:613504; AllianceGenome:HGNC:20760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZF21; HCVP7TP1
    Summary
    Predicted to enable metal ion binding activity. Predicted to be located in endosome and focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in fat (RPKM 36.0), endometrium (RPKM 31.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZFYVE21 in Genome Data Viewer
    Location:
    14q32.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103715810..103733664)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97951867..97969731)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104182147..104200001)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104106328-104106828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6168 Neighboring gene kinesin light chain 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:104140157-104140656 Neighboring gene MPRA-validated peak2255 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104172251-104172810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104172811-104173372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104180589-104181274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104184511-104185021 Neighboring gene X-ray repair cross complementing 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104187639-104188139 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104209353-104210134 Neighboring gene protein phosphatase 1 regulatory subunit 13B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:104260985-104261486 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:104261487-104261986 Neighboring gene small nucleolar RNA SNORD51 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6179 Neighboring gene PPP1R13B divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC2550

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger FYVE domain-containing protein 21
    Names
    FYVE domain containing 21
    HCV p7-transactivated protein 1
    zinc finger, FYVE domain containing 21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198953.2NP_001185882.1  zinc finger FYVE domain-containing protein 21 isoform 1

      See identical proteins and their annotated locations for NP_001185882.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK057816, AL049840, CA311020, CX786145
      Consensus CDS
      CCDS55948.1
      UniProtKB/Swiss-Prot
      Q9BQ24
      Related
      ENSP00000216602.6, ENST00000216602.10
      Conserved Domains (2) summary
      cd15727
      Location:38101
      FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
      pfam16696
      Location:108247
      ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus
    2. NM_024071.4NP_076976.1  zinc finger FYVE domain-containing protein 21 isoform 2

      See identical proteins and their annotated locations for NP_076976.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC005999, CA311020
      Consensus CDS
      CCDS9985.1
      UniProtKB/Swiss-Prot
      A8K3A4, Q86T05, Q96LT1, Q9BQ24
      Related
      ENSP00000310543.2, ENST00000311141.7
      Conserved Domains (2) summary
      cd15727
      Location:38101
      FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
      pfam16696
      Location:108229
      ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      103715810..103733664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      97951867..97969731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)