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    Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 [ Mus musculus (house mouse) ]

    Gene ID: 78943, updated on 5-Sep-2021

    Summary

    Official Symbol
    Ern1provided by MGI
    Official Full Name
    endoplasmic reticulum (ER) to nucleus signalling 1provided by MGI
    Primary source
    MGI:MGI:1930134
    See related
    Ensembl:ENSMUSG00000020715
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ir; Ire; Ire1a; Ire1p; C85377; AI225830; Ire1alpha; 9030414B18Rik
    Expression
    Broad expression in adrenal adult (RPKM 76.6), ovary adult (RPKM 25.1) and 15 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ern1 in Genome Data Viewer
    Location:
    11; 11 E1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106285474..106378701, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106397620..106487796, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (106258934..106349110, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene sodium channel, voltage-gated, type IV, alpha Neighboring gene proline rich 29 Neighboring gene intercellular adhesion molecule 2 Neighboring gene small nucleolar RNA, C/D box 104 Neighboring gene predicted gene, 36220 Neighboring gene predicted gene, 22711

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables endonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables endoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in IRE1-mediated unfolded protein response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in IRE1-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endoplasmic reticulum unfolded protein response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endoplasmic reticulum unfolded protein response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA cleavage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA cleavage involved in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA splicing, via endonucleolytic cleavage and ligation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-serine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine trans-autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of AIP1-IRE1 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of IRE1-RACK1-PP2A complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of IRE1-TRAF2-ASK1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of IRE1-TRAF2-ASK1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase/endoribonuclease IRE1
    Names
    endoplasmic reticulum-to-nucleus signaling 1
    inositol-requiring 1 alpha
    inositol-requiring protein 1
    ire1-alpha
    NP_076402.1
    XP_036012997.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023913.2NP_076402.1  serine/threonine-protein kinase/endoribonuclease IRE1 precursor

      See identical proteins and their annotated locations for NP_076402.1

      Status: PROVISIONAL

      Source sequence(s)
      AB031332
      Consensus CDS
      CCDS25556.1
      UniProtKB/Swiss-Prot
      Q9EQY0
      Related
      ENSMUSP00000001059.3, ENSMUST00000001059.9
      Conserved Domains (5) summary
      cd09769
      Location:32300
      Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
      cd10422
      Location:836961
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      smart00220
      Location:571832
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13982
      Location:568833
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      pfam13360
      Location:25222
      PQQ_2; PQQ-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      106285474..106378701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157104.1XP_036012997.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1

      Conserved Domains (2) summary
      cd10422
      Location:395520
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:127392
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
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