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    Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 [ Mus musculus (house mouse) ]

    Gene ID: 78943, updated on 18-Nov-2018

    Summary

    Official Symbol
    Ern1provided by MGI
    Official Full Name
    endoplasmic reticulum (ER) to nucleus signalling 1provided by MGI
    Primary source
    MGI:MGI:1930134
    See related
    Ensembl:ENSMUSG00000020715 Vega:OTTMUSG00000003414
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ire1a; Ire1p; C85377; AI225830; Ire1alpha; 9030414B18Rik
    Expression
    Broad expression in adrenal adult (RPKM 76.6), ovary adult (RPKM 25.1) and 15 other tissues See more
    Orthologs

    Genomic context

    See Ern1 in Genome Data Viewer
    Location:
    11; 11 E1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (106397620..106487796, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (106258934..106349110, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene proline rich 29 Neighboring gene intercellular adhesion molecule 2 Neighboring gene small nucleolar RNA, C/D box 104 Neighboring gene predicted gene, 36220 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene testis expressed gene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
      Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • IRE1alpha activates chaperones, organism-specific biosystem (from REACTOME)
      IRE1alpha activates chaperones, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Unfolded Protein Response (UPR), organism-specific biosystem (from REACTOME)
      Unfolded Protein Response (UPR), organism-specific biosystemcomputationally inferred pathway (not manually curated)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    endonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    platelet-derived growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    IRE1-mediated unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    IRE1-mediated unfolded protein response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    IRE1-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    activation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum unfolded protein response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    insulin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA cleavage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA cleavage involved in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via endonucleolytic cleavage and ligation ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine trans-autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    AIP1-IRE1 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    IRE1-RACK1-PP2A complex ISO
    Inferred from Sequence Orthology
    more info
     
    IRE1-TRAF2-ASK1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    IRE1-TRAF2-ASK1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase/endoribonuclease IRE1
    Names
    endoplasmic reticulum-to-nucleus signaling 1
    ern1
    inositol-requiring 1 alpha
    inositol-requiring protein 1
    ire1-alpha
    NP_076402.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023913.2NP_076402.1  serine/threonine-protein kinase/endoribonuclease IRE1 precursor

      See identical proteins and their annotated locations for NP_076402.1

      Status: PROVISIONAL

      Source sequence(s)
      AB031332
      Consensus CDS
      CCDS25556.1
      UniProtKB/Swiss-Prot
      Q9EQY0
      Related
      ENSMUSP00000001059.2, OTTMUSP00000003444, ENSMUST00000001059.8, OTTMUST00000007182
      Conserved Domains (5) summary
      cd09769
      Location:32300
      Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
      cd10422
      Location:836961
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      smart00220
      Location:571832
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13982
      Location:568833
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      pfam13360
      Location:25222
      PQQ_2; PQQ-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      106397620..106487796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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