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    Wrnip1 Werner helicase interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 78903, updated on 16-Oct-2021

    Summary

    Official Symbol
    Wrnip1provided by MGI
    Official Full Name
    Werner helicase interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1926153
    See related
    Ensembl:ENSMUSG00000021400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    WHIP; Wrnip; 4833444L21Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 30.0), adrenal adult (RPKM 23.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Wrnip1 in Genome Data Viewer
    Location:
    13; 13 A3.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (32986013..33006593)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (32802030..32822610)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (32893899..32914479)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40876 Neighboring gene myosin light chain kinase family, member 4 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA synthesis involved in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA-dependent DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of DNA-dependent DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATPase WRNIP1
    Names
    Werner helicasae interacting protein 1
    Werner syndrome homolog interacting protein
    werner helicase-interacting protein 1
    NP_084491.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030215.3NP_084491.3  ATPase WRNIP1

      See identical proteins and their annotated locations for NP_084491.3

      Status: VALIDATED

      Source sequence(s)
      AK041886, AK167570, AV237237
      Consensus CDS
      CCDS26427.1
      UniProtKB/Swiss-Prot
      Q91XU0
      Related
      ENSMUSP00000021832.7, ENSMUST00000021832.7
      Conserved Domains (5) summary
      cd00009
      Location:235371
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00734
      Location:1740
      ZnF_Rad18; Rad18-like CCHC zinc finger
      PRK13342
      Location:221656
      PRK13342; recombination factor protein RarA; Reviewed
      pfam12002
      Location:507656
      MgsA_C; MgsA AAA+ ATPase C terminal
      pfam16193
      Location:417506
      AAA_assoc_2; AAA C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      32986013..33006593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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