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    Wsb1 WD repeat and SOCS box-containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 78889, updated on 5-Aug-2018

    Summary

    Official Symbol
    Wsb1provided by MGI
    Official Full Name
    WD repeat and SOCS box-containing 1provided by MGI
    Primary source
    MGI:MGI:1926139
    See related
    Ensembl:ENSMUSG00000017677 Vega:OTTMUSG00000000167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110056B13Rik; 2700038M07Rik
    Expression
    Broad expression in whole brain E14.5 (RPKM 127.9), CNS E14 (RPKM 125.2) and 21 other tissues See more
    Orthologs

    Genomic context

    See Wsb1 in Genome Data Viewer
    Location:
    11; 11 B5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (79239382..79254695, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (79052884..79068197, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 11201 Neighboring gene kinase suppressor of ras 1 Neighboring gene predicted gene, 30413 Neighboring gene predicted gene, 30470 Neighboring gene predicted gene, 30561 Neighboring gene neurofibromin 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    WD repeat and SOCS box-containing protein 1
    Names
    WD-40-repeat-containing protein with a SOCS box 1
    WSB-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042565.3NP_001036030.1  WD repeat and SOCS box-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001036030.1

      Status: VALIDATED

      Source sequence(s)
      AI644176, AK048511, BG069536
      UniProtKB/TrEMBL
      Q8C841
      Conserved Domains (4) summary
      COG2319
      Location:2140
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1757
      7WD40; WD40 repeat [structural motif]
      cl02533
      Location:140178
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl02567
      Location:1146
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_019653.3NP_062627.3  WD repeat and SOCS box-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_062627.3

      Status: VALIDATED

      Source sequence(s)
      AK167394, BB431254, BY097910
      Consensus CDS
      CCDS25118.1
      UniProtKB/Swiss-Prot
      O54927
      UniProtKB/TrEMBL
      Q3TFQ2
      Related
      ENSMUSP00000017821.5, OTTMUSP00000000225, ENSMUST00000017821.11, OTTMUST00000000511
      Conserved Domains (4) summary
      COG2319
      Location:139382
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:135388
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:174212
      7WD40; WD40 repeat [structural motif]
      cl02533
      Location:382420
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      79239382..79254695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534517.2XP_006534580.1  WD repeat and SOCS box-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006534580.1

      UniProtKB/TrEMBL
      Q8C841
      Conserved Domains (4) summary
      COG2319
      Location:2140
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1757
      7WD40; WD40 repeat [structural motif]
      cl02533
      Location:140178
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl02567
      Location:1146
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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