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    Rictor RPTOR independent companion of MTOR, complex 2 [ Mus musculus (house mouse) ]

    Gene ID: 78757, updated on 14-Sep-2021

    Summary

    Official Symbol
    Rictorprovided by MGI
    Official Full Name
    RPTOR independent companion of MTOR, complex 2provided by MGI
    Primary source
    MGI:MGI:1926007
    See related
    Ensembl:ENSMUSG00000050310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AVO3; AW492497; 4921505C17Rik; 6030405M08Rik; D530039E11Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 3.9), cerebellum adult (RPKM 2.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rictor in Genome Data Viewer
    Location:
    15; 15 A1
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (6737827..6829882)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (6708349..6800401)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (6658381..6750401)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene complement component 9 Neighboring gene FYN binding protein Neighboring gene predicted gene 2245 Neighboring gene prohibitin pseudogene Neighboring gene predicted gene, 53882 Neighboring gene oncostatin M receptor Neighboring gene predicted gene, 41261 Neighboring gene predicted gene, 30559

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in TOR signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein kinase B signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of TORC2 complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rapamycin-insensitive companion of mTOR
    Names
    AVO3 homolog
    mAVO3
    protein pianissimo

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030168.3NP_084444.3  rapamycin-insensitive companion of mTOR

      See identical proteins and their annotated locations for NP_084444.3

      Status: VALIDATED

      Source sequence(s)
      AI854883, AK036149, AK173326, BC120903
      Consensus CDS
      CCDS37032.1
      UniProtKB/Swiss-Prot
      Q6QI06
      Related
      ENSMUSP00000051809.7, ENSMUST00000061656.8
      Conserved Domains (5) summary
      pfam14663
      Location:747853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:60437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:10841187
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:525740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922988
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      6737827..6829882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520003.2XP_006520066.1  rapamycin-insensitive companion of mTOR isoform X1

      Conserved Domains (5) summary
      pfam14663
      Location:747853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:60437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:10851187
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922988
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    2. XM_036159639.1XP_036015532.1  rapamycin-insensitive companion of mTOR isoform X2

      Conserved Domains (5) summary
      pfam14663
      Location:465571
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:14155
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:803905
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:355458
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:640709
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    RNA

    1. XR_004938879.1 RNA Sequence

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